Qingyu Chen, PhD
Assistant Professor of Biomedical Informatics and Data ScienceCards
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Assistant Professor of Biomedical Informatics and Data Science
Biography
We have open positions and welcome inquiries from talented and motivated students, postdocs, and collaborators. Please read this page before emailing me so that we can quickly determine whether there may be a good fit.
Dr. Qingyu Chen is a tenure-track Assistant Professor in the Department of Biomedical Informatics & Data Science at Yale School of Medicine, with a secondary appointment in Ophthalmology. His research focuses on artificial intelligence in biomedicine and healthcare, with interests spanning biomedical natural language processing and large language models, medical imaging and multimodal analysis, and trustworthy AI for medical applications. He is the Principal Investigator of an NIH R01 grant on improving the factuality and reasoning of large language models in medicine (see news) and an NIH K99/R00 grant on multimodal AI-assisted disease diagnosis (see news). He has published over 50 first- or last-authored papers among more than 110 total publications, with over 8,300 citations and an h-index of 46 as of May 2026, in journals including Nature, Nature Medicine, Nature Machine Intelligence, Nature Aging, npj Digital Medicine, and Nucleic Acids Research, among others. Before joining Yale in 2024, he completed postdoctoral training at the National Library of Medicine, NIH, and received his PhD in Computer Science (Biomedical Informatics) from the University of Melbourne. He is also a committed educator and mentor who has taught more than 20 courses and mentored over 20 trainees, and has received the NIH Research Mentor Award and Excellence in Teaching Awards.
For more information, please visit https://www.qingyuchen-lab.com.
Appointments
Biomedical Informatics & Data Science
Assistant ProfessorPrimaryOphthalmology
Assistant ProfessorSecondary
Other Departments & Organizations
Education & Training
- PhD
- University of Melbourne, Computer Science and Biomedical Informatics (Microsoft Innovation Award; Excellence in Teaching Award; Top-ranked performance in AI challenge tasks
- BS (Hon)
- The Royal Melbourne Institute of Technology, Computer Science (GPA ranked 1st; First-class Honor; Academic Excellence Award) (2013)
Research
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Overview
Our research focuses on the development, evaluation, and trustworthy use of AI in medicine. We work across language, imaging, and multimodal health data, with particular interests in biomedical NLP, medical LLMs, multimodal and foundation models, ophthalmology and medical imaging AI, and rigorous evaluation for real-world applications in biomedicine and healthcare. For more information, please visit our Research page.
ORCID
0000-0002-6036-1516- View Lab Website
Qingyu Chen Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Hua Xu, PhD
Vipina K. Keloth, PhD
Hyunjae Kim
Ron Adelman, MD, MPH, MBA, FACS
Kalpana Raja, PhD, MRSB, CSci
Lucila Ohno-Machado, MD, MBA, PhD
Publications
2026
Toward federated large language models in medicine: a parameter-efficient framework for privacy-preserving, multi-institutional adaptation
Li A, Chen Y, Long W, Yin Y, Hu Y, Kim H, Zhou W, Zhou Y, Peng H, Ren Y, Ai X, Qin Z, Hu M, Li X, Yu H, Tham Y, Ohno-Machado L, Xu H, Chen Q. Toward federated large language models in medicine: a parameter-efficient framework for privacy-preserving, multi-institutional adaptation. Npj Digital Medicine 2026 DOI: 10.1038/s41746-026-03064-9.Peer-Reviewed Original ResearchAltmetricCiteSure: retrieval-augmented large language models for faithful biomedical citation recommendation
Xie Q, Zhang J, Wang Y, Huang J, Lin F, Weng R, Chen Q, Xu H. CiteSure: retrieval-augmented large language models for faithful biomedical citation recommendation. Journal Of The American Medical Informatics Association 2026, ocag122. PMID: 42551844, DOI: 10.1093/jamia/ocag122.Peer-Reviewed Original ResearchOpportunistic Cardiovascular Risk Assessment in the Eye Clinic: Validation of a Retinal Deep Learning-Based 10-Year ASCVD Estimator
Nusinovici S, Kim H, Seo J, Rim T, Chen Q, Lu Z, Lee C, Tham Y, Nam D, Thakur S, Peng Q, Yu M, Lee G, Park S, Kim S, Wong T, De Silva W, Keenan T, Cheng C, Chew E. Opportunistic Cardiovascular Risk Assessment in the Eye Clinic: Validation of a Retinal Deep Learning-Based 10-Year ASCVD Estimator. Ophthalmology Science 2026, 101386. DOI: 10.1016/j.xops.2026.101386.Peer-Reviewed Original ResearchTutorial: guidance on the use of large language models for medical research
Jin Q, Wan N, Leaman R, Tian S, Wang Z, Yang Y, Wang Z, Xiong G, Lai P, Zhu Q, Hou B, Sarfo-Gyamfi M, Zhang G, Gilson A, Bhasuran B, He Z, Zhang A, Sun J, Weng C, Summers R, Chen Q, Peng Y, Lu Z. Tutorial: guidance on the use of large language models for medical research. Nature Protocols 2026, 1-12. PMID: 42498804, PMCID: PMC13454964, DOI: 10.1038/s41596-026-01408-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAltmetricReticular Pseudodrusen and Cardiovascular Disease or Related Mortality in AREDS and AREDS2.
Elnahry A, Agrón E, Cukras C, Prasad M, Vitale S, Chen Q, Lu Z, Keenan T, Chew E. Reticular Pseudodrusen and Cardiovascular Disease or Related Mortality in AREDS and AREDS2. JAMA Ophthalmology 2026, 144: 655-657. PMID: 42166147, PMCID: PMC13195498, DOI: 10.1001/jamaophthalmol.2026.1525.Peer-Reviewed Original ResearchCitationsAltmetricMed-CoReasoner: Reducing Language Disparities in Medical Reasoning via Language-Informed Co-Reasoning
Gao F, Tong S, Sohn J, Huang J, Jiang J, Xia D, Ittichaiwong P, Veerakanjana K, Kim H, Chen Q, Taylor E, Kobayashi K, Aizawa A, Li I. Med-CoReasoner: Reducing Language Disparities in Medical Reasoning via Language-Informed Co-Reasoning. Proceedings Of The Conference Association For Computational Linguistics Meeting 2026, 2026: 24868-24888. PMID: 42712820, PMCID: PMC13551357, DOI: 10.18653/v1/2026.acl-long.1140.Peer-Reviewed Original ResearchCitationsLMOD \(\boldsymbol{+}\) : A Comprehensive Multimodal Dataset and Benchmark for Developing and Evaluating Multimodal Large Language Models in Ophthalmology
Qin Z, Liu Y, Yin Y, Ding J, Zhang H, Li A, Campbell D, Wu X, Zou K, Keenan T, Chew E, Lu Z, Tham Y, Liu N, Zhang X, Chen Q. LMOD \(\boldsymbol{+}\) : A Comprehensive Multimodal Dataset and Benchmark for Developing and Evaluating Multimodal Large Language Models in Ophthalmology. ACM Transactions On Computing For Healthcare 2026, 7: 1-38. PMID: 42434330, PMCID: PMC13353522, DOI: 10.1145/3801746.Peer-Reviewed Original ResearchCitationsAltmetricMemorization in large language models in medicine prevalence characteristics and implications
Li A, Qian L, Du M, Yin Y, Hu Y, Sun Z, Fu Y, Kim H, Stutz E, Ai X, Xie Q, Zhu R, Huang J, Yang Y, Liu S, Tham Y, Ohno-Machado L, Cho H, Lu Z, Xu H, Chen Q. Memorization in large language models in medicine prevalence characteristics and implications. Nature Communications 2026, 17: 7729. PMID: 42315854, PMCID: PMC13434820, DOI: 10.1038/s41467-026-73779-6.Peer-Reviewed Original ResearchThis study systematically examined what large language models memorize when adapted for medicine, how frequently memorization occurs, how much content is retained, and how it may affect downstream medical applications.ManifoldFormer: Geometric Deep Learning for Neural Dynamics on Riemannian Manifolds
Fu Y, He L, Chen Q. ManifoldFormer: Geometric Deep Learning for Neural Dynamics on Riemannian Manifolds. 2026, 00: 6801-6805. DOI: 10.1109/icassp55912.2026.11463770.Peer-Reviewed Original ResearchCitationsContext for Large Language Model Evaluation in Ophthalmology—Reply
Srinivasan S, Chen Q, Tham Y. Context for Large Language Model Evaluation in Ophthalmology—Reply. JAMA Ophthalmology 2026, 144: 288-288. PMID: 41569551, DOI: 10.1001/jamaophthalmol.2025.5847.Commentaries, Editorials and Letters
Academic Achievements & Community Involvement
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Honors
honor National Library of Medicine Honor Award
12/31/2023National AwardNational Institutes of Healthhonor National Library of Medicine Data Science and Informatics Mentor Awards
07/01/2023National AwardNational Institutes of HealthDetailsUnited Stateshonor Summer Research Mentor Award
07/01/2023National AwardNational Institutes of Healthhonor Fellows Award for Research Excellence
05/01/2023National AwardNational Institutes of Healthhonor Summer Research Mentor Award
07/01/2022National AwardNational Institutes of Health
News
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News
- September 23, 2026
Yale CBB Student Leads Winning Team in MICCAI AI-READI DA-OCT Challenge
- September 08, 2026
Making Medical AI Smarter and Safer
- July 01, 2026
Hyunjae Kim Receives 2026 YBII Postdoctoral Funding
- February 28, 2025Source: Yale Ventures
YSM Faculty Win Awards From the Blavatnik Fund for Innovation at Yale
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