Luis Farhat, MD, PhD
Associate Research Scientist in the Child Study CenterCards
About
Research
Publications
2026
A genomic study of trichotillomania and excoriation disorder in families
Greenspun S, Milanes I, Farhat L, Abdallah S, Bok D, Chen D, Liu W, Teefe E, Bloch M, Fernandez T, Olfson E. A genomic study of trichotillomania and excoriation disorder in families. Translational Psychiatry 2026 PMID: 42315517, DOI: 10.1038/s41398-026-04164-6.Peer-Reviewed Original ResearchCopy-number variantsPolygenic transmission disequilibrium testGenomic studiesBody-focused repetitive behaviorsObsessive-compulsive disorderGenetic studiesIntolerant to loss-of-functionRare copy-number variantsGenome-wide array dataGenome-wide association studiesObsessive-compulsive related disordersLoF-intolerant genesPolygenic scoresParent-offspring triosTransmission disequilibrium testLoss-of-functionSingle-nucleotide polymorphismsExcoriation disorderAssociated with neurodevelopmental disordersGenetic architectureDisequilibrium testAssociation studiesSynapse organizationOver-transmissionEuropean ancestryPharmacological interventions for ADHD: a systematic review and dose–effect network meta-analysis
Nourredine M, Jurek L, Hamza T, Cipriani A, Subtil F, Parlatini V, Farhat L, Veronesi G, Efthimiou O, Salanti G, Cortese S. Pharmacological interventions for ADHD: a systematic review and dose–effect network meta-analysis. The Lancet Psychiatry 2026, 13: 485-495. PMID: 42134365, DOI: 10.1016/s2215-0366(26)00091-x.Peer-Reviewed Original ResearchConceptsADHD medicationNetwork Meta-AnalysisTreatment-resistant populationDose-effect curvesDose-effect patternSystematic reviewCochrane riskNational Institute for Health and Care ResearchADHD criteriaMethylphenidate efficacyClinical guidelinesMeta-analysisAge groupsHigh dosesCochrane risk of bias toolADHDDouble-blind randomised controlled trialRisk of bias toolMethylphenidateAmphetamineMedication dosagePharmacological treatmentWithin-study biasDose-dependent increasePotential reference
2025
Racial, Ethnic and Sex Representation in Tourette's Syndrome Clinical Trials: A Meta‐Analysis
Behling E, Farhat L, Landeros‐Weisenberger A, Bloch M. Racial, Ethnic and Sex Representation in Tourette's Syndrome Clinical Trials: A Meta‐Analysis. Movement Disorders Clinical Practice 2025, 13: 996-1005. PMID: 41392858, PMCID: PMC13071361, DOI: 10.1002/mdc3.70457.Peer-Reviewed Original ResearchRandomized Controlled TrialsParticipation-to-prevalence ratioRandom-effects meta-analysisMeta-analysisProportion of trial participantsEvidence-based treatmentsClinical trialsReporting of raceHealth disparitiesProportion of individualsTS medicationEthnicity dataWeb of Science Core CollectionUS populationTrial participantsMeta-RegressionMinority participantsSex subgroupsScience Core CollectionPrimary outcomeMinority individualsTourette syndromeDisparitiesParticipantsTemporal trendsBenefits and harms of ADHD interventions: umbrella review and platform for shared decision making
Gosling C, Garcia-Argibay M, De Prisco M, Arrondo G, Ayrolles A, Antoun S, Caparos S, Catalán A, Ellul P, Dobrosavljevic M, Farhat L, Fico G, Eudave L, Groenman A, Højlund M, Jurek L, Nourredine M, Oliva V, Parlatini V, Psyllou C, Salazar-de-Pablo G, Tomlinson A, Westwood S, Cipriani A, Correll C, Yon D, Larsson H, Ostinelli E, Shin J, Fusar-Poli P, Ioannidis J, Radua J, Solmi M, Delorme R, Cortese S. Benefits and harms of ADHD interventions: umbrella review and platform for shared decision making. The BMJ 2025, 391: e085875. PMID: 41297970, PMCID: PMC12651917, DOI: 10.1136/bmj-2025-085875.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNon-drug interventionsModerate certainty evidenceAttention deficit/hyperactivity disorder symptomsAttention deficit/hyperactivity disorderEvidence certaintyUmbrella reviewMeta-analysesSeverity of ADHD symptomsEffect sizeCertainty evidenceMeta-analyses of randomised controlled trialsMedium to large effect sizesRandomised controlled trialsADHD symptomsLarge effect sizesQuality of lifeLiving evidence synthesisAMSTAR-2Diagnosis of attention deficit/hyperactivity disorderCognitive behavioral therapyEvidence synthesisMethodological qualityDecision makingGuideline developmentDaily functioningEditorial: Are we too high on medicinal cannabis in child psychiatry? Examining the evidence in Tourette syndrome
Hardeman L, Farhat L, Koenig J, Bloch M. Editorial: Are we too high on medicinal cannabis in child psychiatry? Examining the evidence in Tourette syndrome. Journal Of Child Psychology And Psychiatry 2025, 66: 1781-1783. PMID: 41216975, DOI: 10.1111/jcpp.70075.Commentaries, Editorials and LettersConceptsEndocannabinoid systemPsychiatric disordersTourette syndromeTreatment of psychiatric disordersMedicinal cannabisChronic tic disorderDevelopmental psychopathologyTic disordersPsychological phenomenaChild psychiatryBrain developmentCannabisTouretteDisordersPsychopathologyResearch review articleJCPPPsychiatryBrainSyndromeEvidenceChildrenReview articleLifespanDrugPsychotic symptoms during pharmacological treatment of ADHD: clinical considerations and research needs
Cortese S, Garcia-Argibay M, Oliver D, Chang Z, Farhat L, Bloch M, de Pablo G, Larsson H, Solmi M, Correll C, Fusar-Poli P. Psychotic symptoms during pharmacological treatment of ADHD: clinical considerations and research needs. The Lancet Psychiatry 2025, 13: 266-274. PMID: 41115444, DOI: 10.1016/s2215-0366(25)00248-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsManagement of psychotic symptomsPsychotic symptomsADHD medicationPharmacological treatmentADHD pharmacotherapyPharmacological treatment of ADHDTreatment of ADHDBenefits of pharmacological treatmentOccurrence of psychotic disordersPsychotic disordersADHDMedication typePsychosisEvidence-based preventionPharmacotherapyClinical considerationsSymptomsMedicationIndividualsMethylphenidateClinical managementClinical practiceVulnerabilityResearch prioritiesDisordersMapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis
Shakeshaft A, Farhat L, Dennison C, Eyre O, Oginni O, O'Donovan M, Stringaris A, Leibenluft E, Polanczyk G, Riglin L, Thapar A. Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis. Journal Of Child Psychology And Psychiatry 2025, 67: 333-343. PMID: 40974183, PMCID: PMC12883585, DOI: 10.1111/jcpp.70040.Peer-Reviewed Original ResearchShort Mood and Feelings QuestionnaireMillennium Cohort StudyStrengths and Difficulties QuestionnaireAvon Longitudinal StudyPolygenic scoresOdd-itemBehavior problemsCore symptomsMood and Feelings QuestionnaireAvon Longitudinal Study of ParentsAdolescent mental health servicesDepression polygenic scoresLongitudinal Study of ParentsCore symptoms of ADHDADHD polygenic scoresMental health servicesICD-11 approachOppositional defiant disorderSymptoms of ADHDStudy of parentsHealth servicesFeelings QuestionnaireADHD phenotypeAdolescent irritabilityMood disordersIndividual Participant Data Meta-Analysis: Moderators of Response to Stimulants for Preschool Attention-Deficit/Hyperactivity Disorder
Farhat L, Sugaya L, Bloch M, Childress A, Cortese S, Fatori D, Salum G, Rohde L, Polanczyk G. Individual Participant Data Meta-Analysis: Moderators of Response to Stimulants for Preschool Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child And Adolescent Psychiatry 2025, 65: 781-792. PMID: 40975435, DOI: 10.1016/j.jaac.2025.09.012.Peer-Reviewed Original ResearchADHD symptom severityAttention-deficit/hyperactivity disorderPreschool attention-deficit/hyperactivity disorderEfficacy of stimulationSymptom severityPost hoc natureRandomized placebo-controlled trialModerators of responseAttention-deficit/hyperactivitySymptom severity scoresPlacebo-controlled trialPredictor effectsPreschool childrenPreschoolOlder ageLinear mixed-effects modelsRandom-effects meta-analysesPlaceboMixed-effects modelsWhite childrenModeratelyTreatment effectsBlack childrenDisordersIndividual-level participant dataTrichotillomania and Risk of Alcohol- and Drug-Related Problems
Farhat L, Isomura K, Kuja-Halkola R, Brikell I, Chang Z, D’Onofrio B, Larsson H, Lichtenstein P, de la Cruz L, Sidorchuk A, Mataix-Cols D. Trichotillomania and Risk of Alcohol- and Drug-Related Problems. Biological Psychiatry Global Open Science 2025, 5: 100605. PMID: 41142044, PMCID: PMC12547216, DOI: 10.1016/j.bpsgos.2025.100605.Peer-Reviewed Original ResearchICD-10 diagnosisSubstance-related problemsRelative riskStratified Cox proportional hazard regressionsHazard ratioRisk of problematic substance useCox proportional hazards regressionDrug-related problemsProportional hazards regressionRisk of alcoholismProblematic substance useSociodemographic covariatesClinic registersICD-10Cohort studyHazards regressionPsychiatric historySubstance useDual diagnosisMatched individualsUnaffected individualsDiagnosis of trichotillomaniaPsychiatric disordersFollow-upPatient groupInvestigating the familiality of trichotillomania and excoriation disorder
Chen D, Farhat L, Lebowitz E, Silverman W, Bloch M, Fernandez T, Olfson E. Investigating the familiality of trichotillomania and excoriation disorder. Psychiatry Research 2025, 350: 116560. PMID: 40449230, PMCID: PMC12179820, DOI: 10.1016/j.psychres.2025.116560.Peer-Reviewed Original ResearchConceptsSelf-reported family historyFamily history of mental health disordersFirst-degreeHistory of mental health disordersFamily historyExcoriation disorderFamily history of individualsMental health historyMental health disordersFamily history of anxietyHistory of anxietyCross-sectional survey responsesFirst-degree relativesHigher RatesHealth historyHealth disordersSurvey responsesAged 4Genetic studiesEtiological underpinningsTrichotillomaniaSmall studyAnxietyDepressionIndividuals
Clinical Trials
Current Trials
Valbenazine for Trichotillomania in Adults
IRB ID2000034993RoleSub InvestigatorPrimary Completion Date10/15/2026Recruiting ParticipantsGenderBothAge18 years - 65 years
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