2024
Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia
Hopper S, Weiss D, Mikush N, Jiang B, Spronck B, Cavinato C, Humphrey J, Figueroa C. Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia. Annals Of Biomedical Engineering 2024, 52: 1051-1066. PMID: 38383871, PMCID: PMC11418744, DOI: 10.1007/s10439-024-03440-0.Peer-Reviewed Original ResearchEffects of angiotensin II infusionMouse-to-mouse variationAngiotensin II-induced hypertensionRegional vascular structuresII-induced hypertensionAngiotensin II-infused miceAngiotensin II infusionWild-type miceDescending thoracic aortaGroups of miceSuprarenal abdominal aortaEffects of hypertensionCentral arterial stiffnessDepressed hemodynamicsII infusionIndicator of hypertensionSystemic hypertensionRenovascular diseaseCardiac functionInduced hypertensionDistal aortaThoracic aortaEffects of anesthesiaMouse modelAbdominal aortaA Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels
Ramachandra A, Cavinato C, Humphrey J. A Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels. Annals Of Biomedical Engineering 2024, 52: 958-966. PMID: 38227167, DOI: 10.1007/s10439-023-03432-6.Peer-Reviewed Original ResearchThoracic vesselsVena cavaThoracic aortaCongenital heart surgeryRight pulmonary arterySuperior vena cavaInferior vena cavaRight subclavian arteryThoracic inferior vena cavaWild-type miceAscending thoracic aortaDescending thoracic aortaPulmonary arterySubclavian arteryHeart surgerySurgical interventionVasoactive responsesVenous circulationThoracicCavaNormal structureAortaArteryBiomechanical propertiesVascular system
2018
Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences
Ferruzzi J, Madziva D, Caulk AW, Tellides G, Humphrey JD. Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences. Biomechanics And Modeling In Mechanobiology 2018, 17: 1281-1295. PMID: 29754316, PMCID: PMC8344131, DOI: 10.1007/s10237-018-1026-7.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAorta, AbdominalAorta, ThoracicBiomechanical PhenomenaCardiovascular DiseasesCardiovascular SystemCarotid ArteriesCarotid Artery, CommonDiastoleDisease Models, AnimalElastinExtracellular Matrix ProteinsHemodynamicsHomeostasisHumansMaleMiceModels, CardiovascularPressureRecombinant ProteinsStress, MechanicalTime FactorsVascular StiffnessConceptsCentral arteriesMale wild-type miceArterial wallAberrant matrix remodelingCentral pulse pressureInfrarenal abdominal aortaCommon carotid arteryWild-type miceDiastolic functionCardiovascular consequencesCardiac massHemodynamic sequelaePulse pressureAbdominal aortaThoracic aortaArterial agingVascular agingCommon findingTreatment strategiesCarotid arteryArteryLeft ventricleCarotid vesselsCentral vesselsVivo axial stretch
2017
mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice
Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G. mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1657-1666. PMID: 28751568, PMCID: PMC5574180, DOI: 10.1161/atvbaha.117.309653.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicAortic DiseasesCell ProliferationCollagenElastinEverolimusFocal Adhesion Kinase 1Genetic Predisposition to DiseaseHumansImatinib MesylateMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Mechanotransduction, CellularMice, Inbred C57BLMice, KnockoutMultiprotein ComplexesMuscle, Smooth, VascularPhenotypePhosphorylationProtein Kinase InhibitorsSirolimusTime FactorsTOR Serine-Threonine KinasesVascular StiffnessWilliams SyndromeConceptsElastin deficiencyCollagen accumulationArterial phenotypeNull miceGrowth factorSmooth muscle cell proliferationMuscle cell proliferationEarly postnatal deathInhibition of mTORAortic fibrosisAortic obstructionMedial thickeningAortic stiffeningNeonatal deathLuminal stenosisPharmacological blockadeAbsence of elastinThoracic aortaTherapeutic benefitJuvenile micePostnatal deathMTOR inhibitionAortaHeterozygous lossMice
2016
Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension
Bersi M, Bellini C, Wu J, Montaniel KR, Harrison DG, Humphrey JD. Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension. Hypertension 2016, 67: 890-896. PMID: 27001298, PMCID: PMC4833633, DOI: 10.1161/hypertensionaha.115.06262.Peer-Reviewed Original ResearchConceptsAngiotensin II infusion modelAngiotensin-Induced HypertensionMost clinical assessmentsIntimal-medial thickeningWild-type miceNormal mechanical functionBlood pressureArterial stiffeningThoracic aortaInflammatory responseClinical assessmentEnd organsExuberant productionBlood flowCentral arteriesAdventitial collagenHypertensionWall stressExcessive accumulationInfusion modelMechanical functionWeeksCollagen resultsInflammationArtery
2014
Myh 11 R 247 C / R 247 C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity
Bellini C, Wang S, Milewicz DM, Humphrey JD. Myh 11 R 247 C / R 247 C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity. Journal Of Biomechanics 2014, 48: 113-121. PMID: 25433566, PMCID: PMC4283495, DOI: 10.1016/j.jbiomech.2014.10.031.Peer-Reviewed Original ResearchConceptsThoracic aortaSevere vascular phenotypeAortic aneurysmContractile proteinsLocalized poolsMedial smooth muscle cellsEpigenetic factorsGenetic studiesThoracic aortic diseaseThoracic aortic aneurysmSmooth muscle cellsSuch mutationsMutationsC mutationAortic dissectionAortic diseaseHistopathologic characteristicsMuscle cellsRisk factorsGlycosaminoglycans/proteoglycansNormal adaptationMouse modelNormal biomechanicsAortic structureAorta