Jay Humphrey, PhD
John C. Malone Professor of Biomedical EngineeringCards
About
Research
Publications
2026
Postnatal pulmonary artery development from transcript to tissue
Schwarz E, Ramachandra A, Yeung N, Manning E, Weiss D, Humphrey J. Postnatal pulmonary artery development from transcript to tissue. Journal Of The Royal Society Interface 2026, 23: 20250962. PMID: 42303255, DOI: 10.1098/rsif.2025.0962.Peer-Reviewed Original ResearchConceptsPulmonary artery developmentProximal pulmonary arteriesPulmonary arterySurgical interventionArtery developmentPostnatal developmentPatent ductus arteriosusWild-type miceFontan procedurePulmonary atresiaPulmonary hypertensionDuctus arteriosusSignificant morbidityBiomechanical propertiesGene expressionCongenital conditionPostnatal changesArteryVascular structuresArterial haemodynamicsPathological conditionsHaemodynamicsFontanArteriosusAtresiaA continuum model for collective cell migration in tissues and biomaterials in response to chemo-mechanical stimuli
Shirani M, Humphrey J. A continuum model for collective cell migration in tissues and biomaterials in response to chemo-mechanical stimuli. International Journal Of Engineering Science 2026, 223: 104502. DOI: 10.1016/j.ijengsci.2026.104502.Peer-Reviewed Original ResearchGrowth arrest of thoracic aortic aneurysms in aging Marfan mice
Means C, Mays G, Yeung N, Cavinato C, Manning E, Lam T, Humphrey J, Weiss D. Growth arrest of thoracic aortic aneurysms in aging Marfan mice. AJP Heart And Circulatory Physiology 2026, 331: h115-h129. PMID: 42222959, DOI: 10.1152/ajpheart.00007.2026.Peer-Reviewed Original ResearchConceptsMouse model of Marfan syndromeModel of Marfan syndromeThoracic aortic aneurysmMarfan syndromeMouse modelGrowth arrestAortic aneurysmLimit disease progressionGenetic conditionsMarfan miceProgressive diseaseAneurysm expansionThoracic aortopathyDisease progressionHistological characteristicsExpressed genesTranscriptional profilesProtein abundanceAneurysmLesion growthAssociated proteinSyndromeGene expressionProteomic signaturePathological mechanismsA multiscale computational model of ascending thoracic aortic aneurysm development in Marfan syndrome for in silico trials
Jansen L, Maes L, Verbrugghe P, Segers P, Sips P, Humphrey J, Famaey N. A multiscale computational model of ascending thoracic aortic aneurysm development in Marfan syndrome for in silico trials. Biomechanics And Modeling In Mechanobiology 2026, 25: 49. PMID: 42207208, DOI: 10.1007/s10237-026-02057-7.Peer-Reviewed Original ResearchConceptsAscending thoracic aortic aneurysmMarfan syndromeGene encoding fibrillin-1Thoracic aortic aneurysm developmentAssociated with substantial morbidityMarfan syndrome patientsEncoding fibrillin-1Multisystem connective tissue disorderMarfan syndrome miceAortic aneurysm developmentThoracic aortic aneurysmAscending thoracic aortaConnective tissue disordersMedical treatment optionsPharmacological treatment trialsInhibition of p38 mitogen-activated protein kinaseP38 mitogen-activated protein kinaseSubstantial morbidityAortic aneurysmTissue disordersTreatment optionsPathogenic variantsThoracic aortaAneurysm progressionMitogen-activated protein kinaseHypertension drives thoracic aortic aneurysm and dissection in male, but not female, Marfan mice
Mays G, Humphrey J. Hypertension drives thoracic aortic aneurysm and dissection in male, but not female, Marfan mice. Journal Of The Mechanical Behavior Of Biomedical Materials 2026, 180: 107473. PMID: 42214182, PMCID: PMC13270476, DOI: 10.1016/j.jmbbm.2026.107473.Peer-Reviewed Original ResearchConceptsMarfan miceAortic dilatationChronic blood pressure elevationFemale wild-type miceAscending Aortic DilatationThoracic aortic diseaseMarfan syndrome miceAdult wild-typeHigh-salt dietWild-type miceSusceptible to disease progressionThoracic aortic aneurysmBlood pressure elevationPrimary risk factorAortic diseaseMarfan aortaSalt dietAortic aneurysmAscending aortaSustained elevationEndothelial dysfunctionPressure elevationDisease progressionMouse modelBlood pressureThe aorta in Marfan syndrome: from molecular mechanisms to mechanobiological dysfunction
Humphrey J, Milewicz D. The aorta in Marfan syndrome: from molecular mechanisms to mechanobiological dysfunction. Cardiovascular Research 2026, cvag114. PMID: 42140666, DOI: 10.1093/cvr/cvag114.Peer-Reviewed Original ResearchMarfan syndromeDisease progressionAortic diseaseAutosomal dominant connective tissue disorderEncoding fibrillin-1Thoracic aortic diseaseConnective tissue disordersEffects of pharmacological treatmentElastic fiber organizationDefinitive treatmentOcular tissuesTissue disordersFBN1 variantsPathogenic variantsThoracic aortaPerspective of geneticsPharmacological treatmentMouse modelMonogenic diseasesAortaFibrillin-1Cellular changesMarfanDiseasePathological consequencesMechanisms driving thoracic aortic aneurysm instability
Schwarz E, Li D, Means C, Assi R, Humphrey J. Mechanisms driving thoracic aortic aneurysm instability. Biomechanics And Modeling In Mechanobiology 2026, 25: 43. PMID: 42113285, DOI: 10.1007/s10237-026-02054-w.Peer-Reviewed Original ResearchConceptsNatural historyRate-dependent parametersThoracic aortic aneurysmClinically relevant phenotypesDegree of dilatationAortic aneurysmMaterial propertiesLesion progressionAneurysm growthClinical guidelinesSpectrum of outcomesClinical practiceVascular cellsIn vivoMechanical environmentVascular wallAneurysmThoracicLesionsRisk predictionComputational biomechanical modelRelevant phenotypesPhysics-Informed Machine Learning in Biomedical Science and Engineering.
Ahmadi N, Cao Q, Humphrey J, Karniadakis G. Physics-Informed Machine Learning in Biomedical Science and Engineering. Annual Review Of Biomedical Engineering 2026, 28: 309-336. PMID: 42067517, DOI: 10.1146/annurev-bioeng-110824-124907.Peer-Reviewed Original ResearchConceptsNeural ordinary differential equationsNeural operationsMachine learningBlack-box learningDeep neural operatorDeep learning modelsPhysics-informed machine learningLanguage modelData-driven methodLearned mappingNeural networkIssue of uncertainty quantificationMedical imagesLearning modelsBlack-boxSystem complexityData scarcityPINNEfficient simulationLearningComplex biomedical systemsUncertainty quantificationBiological domainPIMLBiomedical systemsThe role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach
Abdel-Raouf Y, Maes L, Maga L, De Backer J, Sips P, Peirlinck M, Famaey N, Humphrey J, Segers P. The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach. Proceedings Of The Royal Society A 2026, 482: 20250787. DOI: 10.1098/rspa.2025.0787.Peer-Reviewed Original ResearchVascular smooth muscle cellsMechanical propertiesConstrained mixture modelsSimulate remodelingNumerical approachAbstract Vascular smooth muscle cellsElastic energyExtracellular matrix damagePulse wave velocityMedial degenerationCell mechanosensitivityWave velocityExtracellular matrixArterial failureConnective tissue diseaseDegree of hypertensionSmooth muscle cellsSmooth Muscle Cell PlasticitySynthetic vascular smooth muscle cellsStiffened arteriesCommon carotid arteryMouse common carotid arteriesCell phenotypic modulationNon-homeostatic conditionsTissue diseaseA systematic comparison of membrane, shell, and 3D solid formulations for nonlinear vascular biomechanics
Kim T, Ortigosa R, Nama N, Aguirre M, Gil A, Humphrey J, Figueroa C. A systematic comparison of membrane, shell, and 3D solid formulations for nonlinear vascular biomechanics. Journal Of The Mechanical Behavior Of Biomedical Materials 2026, 179: 107423. PMID: 41946235, DOI: 10.1016/j.jmbbm.2026.107423.Peer-Reviewed Original ResearchConceptsVascular biomechanicsRotation-free shell formulationThickness-to-radius ratioIdealized cylindrical geometryComputational costShell formulationMaterial propertiesWall thicknessComparison of membranesComplex geometriesNonlinear membraneBiomechanical applicationsSolid modelQuadratic interpolationCylindrical geometryAxisymmetric solutionsVessel wallWall thickness-to-radius ratioAortic geometryGeometryThicknessFormulationShellWallConvergence analysis