Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling
Paukner D, Humphrey J, Cyron C. Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling. Biomechanics And Modeling In Mechanobiology 2024, 23: 2115-2136. PMID: 39419845, PMCID: PMC11554721, DOI: 10.1007/s10237-024-01884-w.Peer-Reviewed Original ResearchConstrained mixture modelsNonlinear continuum mechanicsSoft biological tissuesChemo-mechanical interactionsSolid mechanicsChemo-mechanical couplingContinuum mechanicsOrdinary differential equationsSignal processingBiological tissuesMixture modelDifferential equationsEquationsSimulate many casesTissue growthOrgan-scaleHemodynamics and Wall Mechanics of Vascular Graft Failure
Szafron J, Heng E, Boyd J, Humphrey J, Marsden A. Hemodynamics and Wall Mechanics of Vascular Graft Failure. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 1065-1085. PMID: 38572650, PMCID: PMC11043008, DOI: 10.1161/atvbaha.123.318239.Peer-Reviewed Original ResearchConceptsVascular graftsTissue-engineered vascular graftsWall mechanicsSolid mechanicsVascular graft failureLoad magnitudeMechanobiological processesLoadMechanobiological stimuliMechanosensitive signaling pathwaysBiomechanical stateWallGraft failureBiomechanical loadingCongenital heart surgeryCoronary artery bypass graftingEnd-organ dysfunctionGraft materialArtery bypass graftingFeedback loopComputational tools