Computational analysis of heart valve growth and remodeling after the Ross procedure
Middendorp E, Braeu F, Baaijens F, Humphrey J, Cyron C, Loerakker S. Computational analysis of heart valve growth and remodeling after the Ross procedure. Biomechanics And Modeling In Mechanobiology 2024, 23: 1889-1907. PMID: 39269523, PMCID: PMC11554944, DOI: 10.1007/s10237-024-01874-y.Peer-Reviewed Original ResearchRoss procedureBlood pressure controlRoot dilatationHomogeneous mixture modelPatient's own pulmonary valveMechanical homeostasisPressure controlAortic heart valvesPublished clinical studiesConstrained mixture modelsHemodynamic environmentPulmonary autograftPulmonary valveLeaflet elongationPressure conditionsClinical studiesG&RHemodynamic loadTissue compositionValve growthTissue depositionMixture modelDilatationHeart valvesAutograftCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz U, Bai S, Nottoli T, Goult B, Humphrey J, Schwartz M. Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis. Science Advances 2024, 10: eadi6286. PMID: 39167642, PMCID: PMC11338229, DOI: 10.1126/sciadv.adi6286.Peer-Reviewed Original ResearchConceptsTissue mechanical homeostasisStiffness sensingExtracellular matrixTalin-1Mechanical homeostasisExtracellular matrix mechanicsIncreased cell spreadingCell spreadingTalinMutationsCellular sensingFibrillar collagenReduced axial stiffnessTissue mechanical propertiesMechanical propertiesAxial stiffnessCompliant substratesHomeostasisRupture pressureArp2/3ARPC5LStiffnessHomeostasis hypothesisResident cellsTissue stiffnessMultiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling
Estrada A, Irons L, Tellides G, Humphrey J. Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling. Journal Of Biomechanics 2024, 169: 112152. PMID: 38763809, PMCID: PMC11141772, DOI: 10.1016/j.jbiomech.2024.112152.Peer-Reviewed Original ResearchAdult aortaTGFB signalingSmooth muscle cellsAortic remodelingCardiac-inducedMouse modelNormal mechanical loadingMuscle cellsPostnatal developmentHemodynamic loadNormal loadAortaMechanical homeostasisMechanical loadingMultiscale computational modelIncreasing loadLoadCell signalingGene productsStructural integrity