Computational analysis of heart valve growth and remodeling after the Ross procedure
Middendorp E, Braeu F, Baaijens F, Humphrey J, Cyron C, Loerakker S. Computational analysis of heart valve growth and remodeling after the Ross procedure. Biomechanics And Modeling In Mechanobiology 2024, 23: 1889-1907. PMID: 39269523, PMCID: PMC11554944, DOI: 10.1007/s10237-024-01874-y.Peer-Reviewed Original ResearchRoss procedureBlood pressure controlRoot dilatationHomogeneous mixture modelPatient's own pulmonary valveMechanical homeostasisPressure controlAortic heart valvesPublished clinical studiesConstrained mixture modelsHemodynamic environmentPulmonary autograftPulmonary valveLeaflet elongationPressure conditionsClinical studiesG&RHemodynamic loadTissue compositionValve growthTissue depositionMixture modelDilatationHeart valvesAutograftCell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study
Maes L, Vervenne T, Hendrickx A, Estrada A, Van Hoof L, Verbrugghe P, Rega F, Jones E, Humphrey J, Famaey N. Cell signaling and tissue remodeling in the pulmonary autograft after the Ross procedure: A computational study. Journal Of Biomechanics 2024, 171: 112180. PMID: 38906711, DOI: 10.1016/j.jbiomech.2024.112180.Peer-Reviewed Original ResearchRoss procedurePulmonary autograftPatient's pulmonary valveTranscription factorsPulmonary valveSmooth muscleActivation of genesAortic positionRelevant transcription factorsTissue remodelingAutograftExcessive dilatationTranscriptome dataGene activationCell signalingSignaling pathwayTarget genesMultiscale modelGenesTissueCellsFailure mechanismCell-scaleMechanical propertiesCell-scale model