Irene Chernova, MD, PhD
Assistant Professor of Medicine (Nephrology)Cards
About
Research
Publications
Featured Publications
Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition
Chernova I, Craft J. Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition. Cell Reports Medicine 2021, 2: 100479. PMID: 35028618, PMCID: PMC8714907, DOI: 10.1016/j.xcrm.2021.100479.Peer-Reviewed Original ResearchThe ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen P, Chandra N, Cantley L, Veselits M, Clark M, Craft J. The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Science Advances 2023, 9: eadf8156. PMID: 36724234, PMCID: PMC9891690, DOI: 10.1126/sciadv.adf8156.Peer-Reviewed Original ResearchConceptsB cellsAutoimmune diseasesAmelioration of proteinuriaLupus nephritis biopsiesB cell infiltrationSodium-potassium adenosine triphosphataseB cell survivalPotassium adenosine triphosphataseLupus nephritisCell infiltrationKidney microenvironmentTissue injuryTherapeutic targetPharmacological inhibitionElevated sodium concentrationLupusHostile microenvironmentHigh expressionKidneySodium concentrationGenetic knockoutCell survivalDiseaseCellsAdenosine triphosphatase
2024
Lupus Nephritis: Immune Cells and the Kidney Microenvironment
Chernova I. Lupus Nephritis: Immune Cells and the Kidney Microenvironment. Kidney360 2024, 5: 1394-1401. PMID: 39120952, PMCID: PMC11441818, DOI: 10.34067/kid.0000000000000531.Peer-Reviewed Original ResearchIntrinsic renal cellsLupus nephritisImmune cellsRenal cellsProgression to end-stage kidney diseaseActivation of immune cellsProinflammatory cytokine milieuSystemic immunosuppressive effectsAutoimmune disease systemic lupus erythematosusDisease systemic lupus erythematosusImmune cell activationSystemic lupus erythematosusEnd-stage kidney diseaseLN therapyCytokine milieuKidney cell functionImmune infiltrationKidney microenvironmentOrgan manifestationsLupus erythematosusAntigen presentationCytokine productionImmunosuppressive effectsKidney diseaseCell activation
2023
Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.
Song W, Sanchez G, Mayer D, Blackburn H, Chernova I, Flavell R, Weinstein J, Craft J. Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection. The Journal Of Immunology 2023, 210: 1861-1865. PMID: 37133336, PMCID: PMC10247523, DOI: 10.4049/jimmunol.2300027.Peer-Reviewed Original ResearchConceptsAge-associated B cellsIL-21Acute lymphocytic choriomeningitis virus infectionB cellsLymphocytic choriomeningitis virus infectionB cell activationHumoral immunityLymphoid organsVirus infectionMouse modelViral infectionB cell developmentCell activationLymphotoxin αVivo generationTissue-specific signalsInfectionDe novo generationOrgan contributionIFNTissue microenvironmentCell developmentLiverPivotal contributorStage-specific roles
2022
The Ion Transporter Na+-K+-ATPase Enables Pathological B Cell Survival in the Kidney Microenvironment of Lupus Nephritis
Chernova I, Craft J. The Ion Transporter Na+-K+-ATPase Enables Pathological B Cell Survival in the Kidney Microenvironment of Lupus Nephritis. Journal Of The American Society Of Nephrology 2022, 33: 486-487. DOI: 10.1681/asn.20223311s1486d.Peer-Reviewed Original ResearchDevelopment of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers
Song W, Antao OQ, Condiff E, Sanchez GM, Chernova I, Zembrzuski K, Steach H, Rubtsova K, Angeletti D, Lemenze A, Laidlaw BJ, Craft J, Weinstein JS. Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Immunity 2022, 55: 290-307.e5. PMID: 35090581, PMCID: PMC8965751, DOI: 10.1016/j.immuni.2022.01.002.Peer-Reviewed Original ResearchConceptsFollicular helper cellsB cellsGC B cellsHelper cellsMemory subsetsRobust recall responsesB cell subsetsGerminal center formationB cell generationAcute infectionCell subsetsRecall responsesTh1 cellsProximal deliveryCD11cGerminal centersIntegrin LFA-1Viral infectionAntibody productionVLA-4Splenic retentionLFA-1TbetBCL6 expressionInfection
2021
Intrarenal B Cells in Systemic Lupus Erythematosus Upregulate Na+-K+-ATPase to Facilitate Survival in a High-Sodium Environment
Chernova I, Craft J. Intrarenal B Cells in Systemic Lupus Erythematosus Upregulate Na+-K+-ATPase to Facilitate Survival in a High-Sodium Environment. Journal Of The American Society Of Nephrology 2021, 32: 452-452. DOI: 10.1681/asn.20213210s1452a.Peer-Reviewed Original Research
2019
Resistant Hypertension Updated Guidelines
Chernova I, Krishnan N. Resistant Hypertension Updated Guidelines. Current Cardiology Reports 2019, 21: 117. PMID: 31471727, DOI: 10.1007/s11886-019-1209-6.BooksConceptsDiagnosis of RHOffice BP measurementsResistant hypertensionMedication optimizationBlood pressureBP measurementsAmerican Heart Association guidelinesUncontrolled blood pressureWhite-coat effectHeart Association guidelinesDevice-based interventionsPurpose of ReviewToLifestyle modificationMost patientsCoat effectInterventional therapyAssociation guidelinesDosing frequencySecondary causesHypertensionPatientsStep-wise approachDiagnosisFurther studiesTreatment
2018
No strict requirement for eosinophils for bone marrow plasma cell survival
Bortnick A, Chernova I, Spencer SP, Allman D. No strict requirement for eosinophils for bone marrow plasma cell survival. European Journal Of Immunology 2018, 48: 815-821. PMID: 29442367, DOI: 10.1002/eji.201747229.Peer-Reviewed Original Research
2016
mTOR has distinct functions in generating versus sustaining humoral immunity
Jones DD, Gaudette BT, Wilmore JR, Chernova I, Bortnick A, Weiss BM, Allman D. mTOR has distinct functions in generating versus sustaining humoral immunity. Journal Of Clinical Investigation 2016, 126: 4250-4261. PMID: 27760048, PMCID: PMC5096901, DOI: 10.1172/jci86504.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntibody FormationCell DifferentiationEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsImmunity, HumoralMechanistic Target of Rapamycin Complex 1MiceMice, TransgenicMultiprotein ComplexesPlasma CellsRegulatory-Associated Protein of mTORSignal TransductionTOR Serine-Threonine KinasesConceptsPlasma cellsBone marrow plasma cellsAntibody-associated diseaseSystemic lupus erythematosusMarrow plasma cellsAntibody-secreting plasma cellsPlasma cell differentiationLineage-specific deletionRole of mTORLupus erythematosusAcute treatmentExogenous antigensHumoral immunityAntibody responseSerum antibodiesMurine modelAntibody synthesisGerminal centersBone marrowCell differentiationMTOR inhibitionRobust protein synthesisMTOR activityRapamycin treatmentMTOR complex 1
Academic Achievements & Community Involvement
News
News
- July 12, 2023
Dr. Chernova Researches How B Cells Survive in the Kidney
- May 09, 2023
Irene Chernova is the 2023 Dostanic Award Recipient
- November 02, 2022
ASN Kidney Week 2022: Presentations from Yale Nephrology
- March 29, 2022
Whitney Besse, Irene Chernova, Receive ASCI Council Awards