Gianvito Masi, MD
Associate Research ScientistCards
About
Research
Publications
2026
Failure of early B cell tolerance and possible BCR signaling dysregulation underlie NF155-mediated autoimmune nodopathies
Roy B, Obaid A, Wang Z, Kovacs K, Ohashi S, Kalayci F, Joo D, Masi G, Coppola C, Das S, Hernandez A, Martin-Aguilar L, Lleixà C, Nowak R, Querol L, O’Connor K. Failure of early B cell tolerance and possible BCR signaling dysregulation underlie NF155-mediated autoimmune nodopathies. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2525717123. PMID: 42008666, PMCID: PMC13123804, DOI: 10.1073/pnas.2525717123.Peer-Reviewed Original Research
2025
IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology
Masi G, Chen K, Bayer A, Bayarri-Olmos R, Pham M, Wallace A, Falso S, Evoli A, Iorio R, Hoehn K, Iwasaki A, Nowak R, O’Connor K. IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology. Brain 2025, 149: awaf410. PMID: 41147199, PMCID: PMC13005154, DOI: 10.1093/brain/awaf410.Peer-Reviewed Original ResearchThis study investigates the role of IgA antibodies in MuSK myasthenia gravis, showing they coexist with IgG4 antibodies, exhibit unique pathogenic potential, and can resist B-cell depletion therapy.Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology
Bayer A, Sanmarco L, Pellerin A, Masi G, Plasencia A, Anderson J, Nowak R, Damato V, Massacesi L, Pham M, Khani-Habibabadi F, Vital H, Higginson-Scott N, Otipoby K, Xing Y, Mascanfroni I, O’Connor K. Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2505984122. PMID: 41118207, PMCID: PMC12582293, DOI: 10.1073/pnas.2505984122.Peer-Reviewed Original ResearchScreening for Congenital Myasthenic Syndromes in Adults With Seronegative Myasthenia Gravis Using Next-Generation Sequencing.
Krenn M, Wagner M, Schuller H, Pugna I, Rath J, Zulehner G, Keritam O, Weng R, Koneczny I, Schiavo E, Damato V, Kleinveld V, Kiss C, Gold V, Quasthoff S, Masi G, O'Connor K, Canning J, Waters P, Lenz D, Blüthner M, Pavlov M, Graf E, Winkelmann J, Löscher W, Zimprich F, Cetin H. Screening for Congenital Myasthenic Syndromes in Adults With Seronegative Myasthenia Gravis Using Next-Generation Sequencing. Neurology 2025, 105: e214177. PMID: 41004697, DOI: 10.1212/wnl.0000000000214177.Peer-Reviewed Original Research
2024
Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR-T therapies in autoimmunity
Bodansky A, Yu D, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green D, Gauthier J, Turtle C, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung A, Rackaityte E, Wang C, Saxena A, de Dios K, Masi G, Nowak R, O'Connor K, Li H, Diaz V, Saloner R, Casaletto K, Gontrum E, Chan B, Kramer J, Wilson M, Utz P, Hill J, Jackson S, Anderson M, DeRisi J. Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR-T therapies in autoimmunity. Journal Of Clinical Investigation 2024, 134: e180012. PMID: 38753445, PMCID: PMC11213466, DOI: 10.1172/jci180012.Peer-Reviewed Original Research
2023
Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology
Pham M, Masi G, Patzina R, Obaid A, Oxendine S, Oh S, Payne A, Nowak R, O’Connor K. Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology. Acta Neuropathologica 2023, 146: 319-336. PMID: 37344701, PMCID: PMC11380498, DOI: 10.1007/s00401-023-02603-y.Peer-Reviewed Original ResearchA score that predicts aquaporin‐4 IgG positivity in patients with longitudinally extensive transverse myelitis
Campetella L, Papi C, Spagni G, Sabatelli E, Mariotto S, Gastaldi M, Masi G, Carta S, Ahmad L, Rossi F, Maniscalco G, De Luca G, Iorio R. A score that predicts aquaporin‐4 IgG positivity in patients with longitudinally extensive transverse myelitis. European Journal Of Neurology 2023, 30: 2534-2538. PMID: 37170839, DOI: 10.1111/ene.15863.Peer-Reviewed Original ResearchUnearthing the Rosetta Stone of public antibody responses.
Masi G. Unearthing the Rosetta Stone of public antibody responses. Science Immunology 2023, 8: eadi4342. PMID: 37146131, DOI: 10.1126/sciimmunol.adi4342.Peer-Reviewed Original ResearchCover crops and rootstocks interaction on vine performances of organic ‘Autumn Pearl’ table grape: first results of OLTRE.BIO research project
Tarricone L, Gentilesco G, Amendolagine A, Mazzone F, Roccotelli S, Masi G. Cover crops and rootstocks interaction on vine performances of organic ‘Autumn Pearl’ table grape: first results of OLTRE.BIO research project. Acta Horticulturae 2023, 181-188. DOI: 10.17660/actahortic.2023.1370.23.Peer-Reviewed Original ResearchClinicoserological insights into patients with immune checkpoint inhibitor‐induced myasthenia gravis
Masi G, Pham M, Karatz T, Oh S, Payne A, Nowak R, Howard J, Guptill J, Juel V, O'Connor K. Clinicoserological insights into patients with immune checkpoint inhibitor‐induced myasthenia gravis. Annals Of Clinical And Translational Neurology 2023, 10: 825-831. PMID: 36924454, PMCID: PMC10187728, DOI: 10.1002/acn3.51761.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Yale University
300 George Street
NEW HAVEN, CT 06511
United States