2016
Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome
Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe 2016, 19: 311-322. PMID: 26962942, PMCID: PMC4821831, DOI: 10.1016/j.chom.2016.02.011.Peer-Reviewed Original ResearchConceptsAnti-retroviral therapyEnteric viromePeripheral CD4 T-cell countLower CD4 T countsCD4 T-cell countHuman immunodeficiency virus (HIV) infectionProgressive HIV infectionT-cell countsImmunodeficiency virus infectionAcquired Immunodeficiency SyndromeHIV-uninfectedUgandan patientsHIV infectionImmunodeficiency syndromeIntestinal translocationDisease progressionVirus infectionART treatmentBacterial microbiomeCell countInfectionGut bacterial communitiesPatientsImmunodeficiencySpecific bacteria
2011
Molecular Mechanisms of HIV Entry
Wilen CB, Tilton JC, Doms RW. Molecular Mechanisms of HIV Entry. Advances In Experimental Medicine And Biology 2011, 726: 223-242. PMID: 22297516, DOI: 10.1007/978-1-4614-0980-9_10.Peer-Reviewed Original ResearchConceptsHIV entryOnly viral surface proteinHuman immunodeficiency virus (HIV) entryHumoral immune responseMembrane fusion machineryCoreceptor-binding siteHost protein CD4Viral surface proteinsHIV infectionSmall molecule inhibitorsImmune responseChemokine coreceptorsFusion machineryViral tropismClinical treatmentVirus entryMolecular mechanismsHost cellsFacilitates exposureMolecule inhibitorsGp41 subunitSurface proteinsViral genomeAmino acidsCD4