2024
Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research Program
Wride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, llae451. PMID: 39425681, DOI: 10.1093/ced/llae451.Peer-Reviewed Original ResearchValidation of the Delphi Consensus Diagnostic Criteria for Necrobiotic Xanthogranuloma
Bassir F, Valido K, Maciejewski K, Damsky W, Nelson C. Validation of the Delphi Consensus Diagnostic Criteria for Necrobiotic Xanthogranuloma. JAMA Dermatology 2024, 160 PMID: 39356540, PMCID: PMC11447626, DOI: 10.1001/jamadermatol.2024.3198.Peer-Reviewed Original Research54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research program
Wride M, Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. 54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research program. Journal Of The American Academy Of Dermatology 2024, 91: ab147. DOI: 10.1016/j.jaad.2024.07.584.Peer-Reviewed Original ResearchEnhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticles
Chang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticles. Journal Of Investigative Dermatology 2024 PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.Peer-Reviewed Original ResearchMonophosphoryl lipid ATumor microenvironmentImmunomodulatory agentsStimulation of anti-tumor immune responseEfficacy of monophosphoryl lipid AT-helper (Th)1 responsesAnti-tumor immune responseTumor-draining lymph nodesToxicity associated with systemic administrationImmune responseModel of malignant melanomaAgonist monophosphoryl lipid ABiodegradable nanoparticlesImmunogenic tumor microenvironmentAntitumor immune responseDraining lymph nodesSystemic side effectsNatural killer cellsGradual drug releaseKiller cellsAntitumor efficacyMalignant melanomaImproved survivalLymph nodesChemotherapeutic agentsPlasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts
Sand J, Jessen H, Leeming D, Yu S, Lee C, Hu B, Sun Y, Adams T, Pivarnik T, Liu A, Woo S, McGovern J, Fiorini V, Saber T, Higuero-Sevilla J, Gulati M, Kaminski N, Damsky W, Shaw A, Mohanty S, Goobie G, Zhang Y, Herzog E, Ryu C. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts. Thorax 2024, thorax-2023-221095. PMID: 39117421, DOI: 10.1136/thorax-2023-221095.Peer-Reviewed Original ResearchSarcoidosis cohortMultiorgan diseasePRO-C3Interleukin-4Case Control Etiologic Study of SarcoidosisPlasma levels of interleukin-4Alpha-1 antitrypsin deficiencyLevels of interleukin-4Pathogenesis of sarcoidosisC6MC3MHealthy control patientsStudy of sarcoidosisGenomic researchAbnormal extracellular matrixAssociated with dermatological diseaseCollagen degradationScadding stageCorticosteroid useComplex diseasesPRO-C6Control patientsIL-13IL-5IL-9Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders
Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. Journal Of Allergy And Clinical Immunology 2024 PMID: 39098508, DOI: 10.1016/j.jaci.2024.07.021.Peer-Reviewed Original ResearchCutaneous sarcoidosisNecrobiotic xanthogranulomaGranulomatous disorderGranuloma annulareNecrobiosis lipoidicaImmune activationMacrophage activationCutaneous granulomatous disordersPattern of immune activationType 2 immune activationActivation of Th1Pattern of Th1Alternative macrophage activationAlternative macrophage polarizationAlteration of extracellular matrixPatterns of macrophage activationCases of CSPredominant inflammationExtracellular matrix alterationsT-helperTh17 immunityTh2 polarizationIL-32Histological changesChemokine signalingLB863 Spatial transcriptomics reveals structurally organized and distinct immune polarization in inflammatory cutaneous granulomatous disorders
Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. LB863 Spatial transcriptomics reveals structurally organized and distinct immune polarization in inflammatory cutaneous granulomatous disorders. Journal Of Investigative Dermatology 2024, 144: s150. DOI: 10.1016/j.jid.2024.06.1243.Peer-Reviewed Original Research057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes
Wang Y, Yu W, Micevic G, Daccache J, Wang A, Park K, Wang G, Palmatier M, Wheeler J, King B, Damsky W. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes. Journal Of Investigative Dermatology 2024, 144: s10. DOI: 10.1016/j.jid.2024.06.073.Peer-Reviewed Original Research795 Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells
Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. 795 Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Journal Of Investigative Dermatology 2024, 144: s139. DOI: 10.1016/j.jid.2024.06.811.Peer-Reviewed Original ResearchPediatric cutaneous Crohn disease: A case series of 89 patients and review
McKay G, Liu L, Shaw K, Shakshouk H, Murphy M, Damsky W, Ortega‐Loayza A, Caplan A, Arkin L, Shields B. Pediatric cutaneous Crohn disease: A case series of 89 patients and review. Pediatric Dermatology 2024, 41: 807-813. PMID: 39011834, DOI: 10.1111/pde.15689.Peer-Reviewed Original ResearchBiologic therapyPediatric patientsCrohn's diseaseMetastatic Crohn's diseaseInterleukin-12/23 inhibitorsCutaneous granulomatous inflammationIntestinal Crohn's diseaseDiscordant therapyTNF blockadeOral corticosteroidsInterleukin-12/23Dual therapyRetrospective reviewPediatric casesCutaneous CDMechanism of actionPatient demographicsCase seriesChart reviewClinical characteristicsPartial clearanceGranulomatous inflammationCase of CCDSmall molecule inhibitorsCutaneous diseaseAnti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency.
Cohen J, Damsky W. Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. New England Journal Of Medicine 2024, 391: 188-189. PMID: 38986070, DOI: 10.1056/nejmc2404977.Peer-Reviewed Original ResearchGranuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics
Mohanty C, Singh C, Daccache J, Damsky W, Kendziorski C, Yan D, Prasad A, Zhang D, Keenan T, Drolet B, Ahmad N, Shields B. Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. Journal Of Investigative Dermatology 2024 PMID: 38844128, DOI: 10.1016/j.jid.2024.04.024.Peer-Reviewed Original ResearchGranuloma annulareGranulomatous inflammationFDA-approved therapiesInflammatory signaling cascadesImpact of GAIFN-gImmune cellsInterleukin-32Idiopathic conditionTh2 signalsAdaptive immunityInterstitial patternMacrophage activationGene expression changesMolecular driversQuality of lifeGenome-wide gene expression changesMacrophage polarizationGranulomaMacrophagesTissue remodelingInflammationTNF signalingLocal gene expression patternsSpatial transcriptomicsSuccessful treatment of pityriasis rubra pilaris with brodalumab after nonresponse to IL-17A inhibition: A role for the innate cytokine IL-17C
Valido K, Murphy M, Leventhal J, Damsky W. Successful treatment of pityriasis rubra pilaris with brodalumab after nonresponse to IL-17A inhibition: A role for the innate cytokine IL-17C. JAAD Case Reports 2024, 48: 85-87. PMID: 38783931, PMCID: PMC11111584, DOI: 10.1016/j.jdcr.2024.04.010.Peer-Reviewed Original ResearchCharacterizing interstitial lung disease in patients with psoriasis: a cross-sectional analysis in the National Institutes of Health’s All of Us Research Program
Shaw V, Damsky W, Homer R, Cohen J. Characterizing interstitial lung disease in patients with psoriasis: a cross-sectional analysis in the National Institutes of Health’s All of Us Research Program. Clinical And Experimental Dermatology 2024, 49: 1083-1084. PMID: 38618708, DOI: 10.1093/ced/llae132.Peer-Reviewed Original ResearchElectronic health recordsUs Research ProgramCross-sectional analysisNational Institutes of HealthHealth recordsInstitutes of HealthConfounding variablesRate of interstitial lung diseaseMultivariate modelNational InstituteLung diseaseAssociationInterstitial lung diseaseConfoundingHealthORParticipantsParadoxical Psoriasis
Abdelghaffar M, Kottilil S, Murphy M, Cohen J, Damsky W. Paradoxical Psoriasis. Dermatologic Clinics 2024, 42: 471-480. PMID: 38796276, DOI: 10.1016/j.det.2024.02.011.Peer-Reviewed Original ResearchTreatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach
Valido K, Patel V, Murphy M, Junejo M, Patel D, Deutsch A, Turner N, Zaki T, King B, Damsky W, Nelson C. Treatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach. JAAD Case Reports 2024, 48: 49-53. PMID: 38774671, PMCID: PMC11107093, DOI: 10.1016/j.jdcr.2024.03.020.Peer-Reviewed Original ResearchDupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells
Bangert C, Alkon N, Chennareddy S, Arnoldner T, Levine J, Pilz M, Medjimorec M, Ruggiero J, Cohenour E, Jonak C, Damsky W, Griss J, Brunner P. Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells. Nature Communications 2024, 15: 2839. PMID: 38565563, PMCID: PMC10987549, DOI: 10.1038/s41467-024-46540-0.Peer-Reviewed Original ResearchConceptsHead and neck dermatitisAtopic dermatitisNeck dermatitisT cellsHealthy control skinType 2 inflammationDupilumab treatmentImmune signaturesReceptor upregulationActivation markersClinical efficacyPunch biopsyHistopathological featuresDe novo appearanceIL-22Single-cell RNA sequencingDrug effectsDupilumabSide effectsControl skinDermatitisKeratinocyte activationUntreated ADTreatmentRNA sequencing
2023
Granuloma annulare is associated with an increased risk of hematologic malignancies: A multicenter cohort study using TriNetX
Garate D, Thang C, Damsky W, Rosenbach M, Golovko G, Wilkerson M, Barbieri J. Granuloma annulare is associated with an increased risk of hematologic malignancies: A multicenter cohort study using TriNetX. Journal Of The American Academy Of Dermatology 2023, 90: 862-864. PMID: 38147901, DOI: 10.1016/j.jaad.2023.12.028.Peer-Reviewed Original ResearchRetrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining
Hwang E, Lee T, Okifo K, Murphy M, Damsky W. Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining. International Journal Of Dermatology 2023, 63: 655-659. PMID: 38135676, PMCID: PMC11055676, DOI: 10.1111/ijd.16998.Peer-Reviewed Original ResearchObsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program
Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program. Archives Of Dermatological Research 2023, 316: 11. PMID: 38038754, DOI: 10.1007/s00403-023-02767-3.Peer-Reviewed Original Research