Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication
Jacob Y, Bergamin E, Donoghue MT, Mongeon V, LeBlanc C, Voigt P, Underwood CJ, Brunzelle JS, Michaels SD, Reinberg D, Couture JF, Martienssen RA. Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication. Science 2014, 343: 1249-1253. PMID: 24626927, PMCID: PMC4049228, DOI: 10.1126/science.1248357.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArabidopsisArabidopsis ProteinsCatalytic DomainConserved SequenceCrystallography, X-RayDNA ReplicationEpigenesis, GeneticGene Expression Regulation, PlantHeterochromatinHistonesMethylationMethyltransferasesMitosisMolecular Sequence DataProtein Processing, Post-TranslationalThreonineConceptsHistone H3 variantWidespread regulatory functionsHistone-modifying enzymesARABIDOPSIS TRITHORAXMitotic inheritanceH3 variantHistone variantsHeterochromatin replicationSET domainDNA replicationPosttranslational modificationsCatalytic domainRegulatory functionsPosition 31Protein 5ATXR5H3.3Selective methylationReplicationATXR6TrithoraxH3K27me1ParalogsHeterochromatizationH3.1