2010
MAG and OMgp Synergize with Nogo-A to Restrict Axonal Growth and Neurological Recovery after Spinal Cord Trauma
Cafferty WB, Duffy P, Huebner E, Strittmatter SM. MAG and OMgp Synergize with Nogo-A to Restrict Axonal Growth and Neurological Recovery after Spinal Cord Trauma. Journal Of Neuroscience 2010, 30: 6825-6837. PMID: 20484625, PMCID: PMC2883258, DOI: 10.1523/jneurosci.6239-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBiotinCells, CulturedDextransDisease Models, AnimalFemaleFunctional LateralityGanglia, SpinalGPI-Linked ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutMutationMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNerve Tissue ProteinsNeuronsNogo ProteinsPyramidal TractsReceptors, Cell SurfaceReceptors, SerotoninRecovery of FunctionSpinal Cord InjuriesConceptsAxonal growthSpinal Cord Injury StudyMutant miceGreater axonal growthGreater behavioral recoverySpinal cord traumaWild-type miceAxonal growth inhibitionHeterozygous mutant miceDeficient myelinNeurological recoveryCNS damageTriple-mutant miceBehavioral recoveryCord traumaFunctional recoveryNeurological functionMyelin inhibitorsAxonal regrowthReceptor mechanismsInjury studiesMyelin inhibitionDecoy receptorOptimal chanceMice
2000
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
Kerr B, Cafferty W, Gupta Y, Bacon A, Wynick D, McMahon S, Thompson S. Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury. European Journal Of Neuroscience 2000, 12: 793-802. PMID: 10762308, DOI: 10.1046/j.1460-9568.2000.00967.x.Peer-Reviewed Original ResearchConceptsPeripheral nerve injuryNerve injuryBehavioral hypersensitivityExogenous galaninNociceptive processingAdult ratsNervous systemSpinal cord dorsal hornMutant miceNociceptive sensory inputsPersistent behavioral hypersensitivityNeuropathic pain behaviorsNeurotransmitter/neuromodulatorGalanin knockout miceCentral nervous systemC-fos expressionEndogenous galaninGalanin levelsNociceptive deficitsWild-type controlsDorsal hornChronic administrationGalanin expressionExcitatory effectsIntrathecal delivery