2012
Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways
Wang X, Hasan O, Arzeno A, Benowitz LI, Cafferty WB, Strittmatter SM. Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways. Experimental Neurology 2012, 237: 55-69. PMID: 22728374, PMCID: PMC3418451, DOI: 10.1016/j.expneurol.2012.06.009.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsAxonal regenerationPharmacological approachesCrush injuryChondroitin sulfate proteoglycanInjury siteNeural repairOptic nerve crush injuryDorsal root ganglion neuronsNgr1-/- miceNerve crush injurySciatic nerve axotomySpinal cord injury sitePrimary afferent fibersEffective pharmacological approachSpinal cord injuryAdult mammalian neuronsIntrinsic growth potentialGlial inhibitorsTriple therapyNerve axotomyViral gene therapyWT miceAfferent fibersCNS injury
2004
Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice
Cafferty WB, Gardiner NJ, Das P, Qiu J, McMahon SB, Thompson SW. Conditioning Injury-Induced Spinal Axon Regeneration Fails in Interleukin-6 Knock-Out Mice. Journal Of Neuroscience 2004, 24: 4432-4443. PMID: 15128857, PMCID: PMC6729445, DOI: 10.1523/jneurosci.2245-02.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCell DifferentiationCells, CulturedCholera ToxinDisease Models, AnimalDrug SynergismGanglia, SpinalGAP-43 ProteinInterleukin-6MaleMiceMice, KnockoutNerve Growth FactorsNerve RegenerationNeuronsRatsRats, WistarSciatic NerveSciatic NeuropathySpinal CordSpinal Cord InjuriesConceptsDorsal root gangliaInterleukin-6Sensory neuronsConditioning injuryDorsal columnsIntact dorsal root gangliaSoluble IL-6 receptorHost CNS tissueAdult sensory neuronsIL-6 upregulationDorsal column axonsDorsal column afferentsExogenous IL-6Cytokine interleukin-6IL-6 receptorGrowth-associated protein GAP43Neurite extensionConditioning lesionChondroitin sulfate proteoglycanNT-3Myelin inhibitorsDRG cellsRoot gangliaSciatic nerveInjury site