2008
Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function
Cafferty WB, Bradbury EJ, Lidierth M, Jones M, Duffy PJ, Pezet S, McMahon SB. Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function. Journal Of Neuroscience 2008, 28: 11998-12009. PMID: 19005065, PMCID: PMC3844838, DOI: 10.1523/jneurosci.3877-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAfferent PathwaysAnimalsChondroitin ABC LyaseChondroitin Sulfate ProteoglycansDisease Models, AnimalMaleNerve RegenerationNeural ConductionNeuronal PlasticityRatsRats, WistarRecovery of FunctionRhizotomySensation DisordersSensory Receptor CellsSpinal CordSpinal Cord InjuriesSpinal Nerve RootsTreatment OutcomeConceptsSpinal cord injuryFunctional restorationSensory functionSpinal sensory functionsPrimary afferent terminalsVivo electrophysiological recordingsIntact spinal circuitsEnzyme chondroitinase ABCIntrinsic growth potentialAfferent terminalsBehavioral recoveryIntraspinal injectionCord injurySensory deficitsSpinal cordSpinal circuitsAdult ratsMature CNSTherapeutic interventionsExperimental therapeuticsElectrophysiological recordingsAxon growthInjuryIntact pathwaysEnhance function
2007
Functional Axonal Regeneration through Astrocytic Scar Genetically Modified to Digest Chondroitin Sulfate Proteoglycans
Cafferty WB, Yang SH, Duffy PJ, Li S, Strittmatter SM. Functional Axonal Regeneration through Astrocytic Scar Genetically Modified to Digest Chondroitin Sulfate Proteoglycans. Journal Of Neuroscience 2007, 27: 2176-2185. PMID: 17329414, PMCID: PMC2848955, DOI: 10.1523/jneurosci.5176-06.2007.Peer-Reviewed Original ResearchConceptsChondroitin sulfate proteoglycanRole of CSPGsTransgenic miceSensory axon regenerationMotor function recoveryFunctional axonal regenerationCombination-based therapyEnzyme chondroitinase ABCSulfate proteoglycanDorsal hemisectionAxotomized neuronsDorsal rhizotomyCorticospinal axonsCNS injuryFunction recoveryMyelin inhibitorsAxonal regenerationAstrocytic scarLocal efficacyTraumatic injuryAxon regenerationLesion siteInhibitory moleculesFunctional regenerationChondroitinase ABC