2021
Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9
Nierzwicki L, East K, Morzan U, Arantes P, Batista V, Lisi G, Palermo G. Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9. ELife 2021, 10: e73601. PMID: 34908530, PMCID: PMC8741213, DOI: 10.7554/elife.73601.Peer-Reviewed Original ResearchMeSH KeywordsAllosteric RegulationCRISPR-Cas SystemsGenetic VariationGenotypeMolecular Dynamics SimulationMolecular StructureMutationStreptococcus pyogenesConceptsHNH domainAllosteric communicationCatalytic HNH domainDNA recognition regionSpecificity-enhancing mutationsGenome editing capabilitiesAllosteric signalingAllosteric signalMutations perturbAllosteric hotspotsSpecificity enhancementCas9 endonucleaseMutational studiesDNA recognitionAllosteric connectivityAllosteric roleMolecular toolsAllosteric structureRecognition regionMolecular levelBiochemical studiesDNA cleavageSolution NMRMutationsCatalytic site
2014
Kinetics of Thermal Activation of an Ultraviolet Cone Pigment
Mooney V, Sekharan S, Liu J, Guo Y, Batista V, Yan E. Kinetics of Thermal Activation of an Ultraviolet Cone Pigment. Journal Of The American Chemical Society 2014, 137: 307-313. PMID: 25514632, DOI: 10.1021/ja510553f.Peer-Reviewed Original ResearchConceptsTransmembrane helix 6UV pigmentsUnprotonated Schiff baseVisual pigmentsCone pigmentsDim-light visionExtracellular loop 2Vertebrate visual pigmentsMolecular evolutionUltraviolet pigmentsOpsin proteinHelix 6Retinyl chromophoreLoop 2UV cone pigmentBovine rhodopsinRod pigmentRhodopsinHydrogen bonding networkSalt bridgeIonone ringPigmentsSchiff base chromophoreSteric restraintsActivation
2013
Hydroxamate Anchors for Improved Photoconversion in Dye-Sensitized Solar Cells
Brewster TP, Konezny SJ, Sheehan SW, Martini LA, Schmuttenmaer CA, Batista VS, Crabtree RH. Hydroxamate Anchors for Improved Photoconversion in Dye-Sensitized Solar Cells. Inorganic Chemistry 2013, 52: 6752-6764. PMID: 23687967, DOI: 10.1021/ic4010856.Peer-Reviewed Original ResearchMeSH KeywordsColoring AgentsElectric Power SuppliesHydroxamic AcidsMolecular StructureOrganometallic CompoundsPhotochemical ProcessesSolar EnergyConceptsDye-sensitized solar cellsSolar cellsRuthenium polypyridyl dyesElectricity conversion efficiencyExhibit high efficiencyCurrent density–voltage (J–V) characteristic curvesAnchoring groupDye moleculesElectron transferMolecular adsorbatesPhotocatalytic applicationsTiO2 surfaceCell performanceSemiconductor surfacesConversion efficiencyStructure/function relationshipsFundamental insightsFuture applicationsSimilar conditionsHigh efficiencyPhotoanodeElectrolyteFunction relationshipsAdsorbatesSurface
2008
Acetylacetonate Anchors for Robust Functionalization of TiO2 Nanoparticles with Mn(II)−Terpyridine Complexes
McNamara WR, Snoeberger RC, Li G, Schleicher JM, Cady CW, Poyatos M, Schmuttenmaer CA, Crabtree RH, Brudvig GW, Batista VS. Acetylacetonate Anchors for Robust Functionalization of TiO2 Nanoparticles with Mn(II)−Terpyridine Complexes. Journal Of The American Chemical Society 2008, 130: 14329-14338. PMID: 18831585, DOI: 10.1021/ja805498w.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationElectron Spin Resonance SpectroscopyElectronsHydroxybutyratesLightManganeseMembranes, ArtificialModels, ChemicalModels, MolecularMolecular StructureNanoparticlesOrganometallic CompoundsOxidation-ReductionParticle SizePentanonesPhotochemistryPorosityPyridinesSensitivity and SpecificitySpectrophotometry, UltravioletSurface PropertiesTime FactorsTitaniumWaterConceptsInterfacial electron injectionTiO2 nanoparticlesRobust functionalizationTransition metal ionsVisible light sensitizationElectron injectionInterfacial electron transferColloidal thin filmsTerpy complexesPhotocatalytic complexesOxidation chemistryEffective catalystCoupling reactionElectron transferNanoparticlesVariety of scaffoldsComplex of caPhotovoltaic devicesFunctionalizationSubpicosecond time scaleAqueous suspensionOxidative conditionsThin filmsComplexesTransient measurements