Pharmaceutical formulation affects titanocene transferrin interactions
Buettner K, Snoeberger R, Batista V, Valentine A. Pharmaceutical formulation affects titanocene transferrin interactions. Dalton Transactions 2011, 40: 9580-9588. PMID: 21847473, DOI: 10.1039/c1dt10805k.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsExcipientsHumansOrganometallic CompoundsProtein BindingThermodynamicsTransferrinConceptsTitanocene dichlorideHuman serum transferrinUV/FT-ICR mass spectrometryMolar absorptivityPH-dependent speciationDifferent molar absorptivitiesDFT calculationsSynergistic anionFluorescence quenchingPharmaceutical formulationsMass spectrometryTransfer energyAnticancer activitySerum transferrinAnticancer drugsPhase II human clinical trialsAbsorptivityNMRAnionsHuman clinical trialsDichloridePotential vehicleSpectrometryTi