2019
A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration
Sekine Y, Lindborg JA, Strittmatter SM. A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration. Journal Of Biological Chemistry 2019, 295: 2175-2183. PMID: 31748413, PMCID: PMC7039549, DOI: 10.1074/jbc.ra119.009896.Peer-Reviewed Original ResearchConceptsMembrane-associated proteinsRecombinant protein expressionMatrix-associated proteinOligodendrocyte plasma membraneProteolytic C-terminal fragmentsRegeneration assaysC-terminal fragmentPlasma membraneNeurite outgrowth inhibitor NogoAxonal regenerationExosomal releaseDiffusible inhibitorC-terminalSiRNA knockdownCleavage siteCultured cellsLong fragmentPrimary cortical neuron culturesCentral nervous system traumaExosomesEnzyme inhibitor treatmentExosomal fractionSpinal cord crush injuryCerebral cortex neuronsProtein
2007
The reticulons: a family of proteins with diverse functions
Yang YS, Strittmatter SM. The reticulons: a family of proteins with diverse functions. Genome Biology 2007, 8: 234. PMID: 18177508, PMCID: PMC2246256, DOI: 10.1186/gb-2007-8-12-234.Peer-Reviewed Original ResearchConceptsDiverse functionsEndoplasmic reticulum-Golgi traffickingReticulon homology domainMembrane-associated proteinsAmino-terminal domainFamily of proteinsEukaryotic kingdomsMembrane morphogenesisHomology domainHydrophilic loopReticulon 4Reticulon familyReticulonsDiversity of structuresExpression patternsVesicle formationEndoplasmic reticulumAmino acidsCell surfaceHydrophobic regionAxon growthDiverse groupNeurodegenerative diseasesProteinAmyotrophic lateral sclerosis