2023
Validation of the European SCORE2 models in a Canadian primary care cohort
Sud M, Sivaswamy A, Austin P, Abdel-Qadir H, Anderson T, Khera R, Naimark D, Lee D, Roifman I, Thanassoulis G, Tu K, Wijeysundera H, Ko D. Validation of the European SCORE2 models in a Canadian primary care cohort. European Journal Of Preventive Cardiology 2023, 31: 668-676. PMID: 37946603, PMCID: PMC11025037, DOI: 10.1093/eurjpc/zwad352.Peer-Reviewed Original ResearchPrimary care cohortAtherosclerotic cardiovascular diseaseLow-risk regionsCare cohortC-statisticOlder personsElectronic medical record dataLarge Canadian cohortMedical record dataYears of ageYoung personASCVD riskCanadian cohortCardiovascular diseaseOlder womenIndividuals 70Age groupsSCORE2CohortRecord dataWomenMenRiskPersonsDiseaseClinical Risk Prediction Models with Meta-Learning Prototypes of Patient Heterogeneity
Zhang L, Khera R, Mortazavi B. Clinical Risk Prediction Models with Meta-Learning Prototypes of Patient Heterogeneity. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2023, 00: 1-4. PMID: 38083199, PMCID: PMC11007255, DOI: 10.1109/embc40787.2023.10340765.Peer-Reviewed Original ResearchMULTINATIONAL PATTERNS OF SECOND-LINE ANTI-HYPERGLYCEMIC DRUG INITIATION IN ESTABLISHED CARDIOVASCULAR DISEASE: A FEDERATED PHARMACOEPIDEMIOLOGIC EVALUATION IN LEGEND-T2DM
Khera R, Dhingra L, Li K, Aminorroaya A, Zhou J, Arshad F, Bu F, Dorr D, Falconer T, French T, Lau W, Lu Y, Man K, Matheny M, Minty E, Nishimura A, Ostropolets A, Seager S, Y.F. W, Yang J, Yin C, Hripcsak G, Krumholz H. MULTINATIONAL PATTERNS OF SECOND-LINE ANTI-HYPERGLYCEMIC DRUG INITIATION IN ESTABLISHED CARDIOVASCULAR DISEASE: A FEDERATED PHARMACOEPIDEMIOLOGIC EVALUATION IN LEGEND-T2DM. Journal Of The American College Of Cardiology 2023, 81: 1646. DOI: 10.1016/s0735-1097(23)02090-9.Peer-Reviewed Original ResearchDrug initiationDiseaseMECHANISTIC EVALUATION OF AN AI-DRIVEN CLINICAL DECISION SUPPORT TOOL TO PERSONALIZE THE USE OF ANATOMICAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE
Oikonomou E, Suchard M, Miller E, Velazquez E, Khera R. MECHANISTIC EVALUATION OF AN AI-DRIVEN CLINICAL DECISION SUPPORT TOOL TO PERSONALIZE THE USE OF ANATOMICAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2023, 81: 1360. DOI: 10.1016/s0735-1097(23)01804-1.Peer-Reviewed Original Research
2021
Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease
Secemsky EA, Butala N, Raja A, Khera R, Wang Y, Curtis JP, Maddox TM, Virani SS, Armstrong EJ, Shunk KA, Brindis RG, Bhatt D, Yeh RW. Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e010323. PMID: 34372676, PMCID: PMC8485756, DOI: 10.1161/circinterventions.120.010323.Peer-Reviewed Original ResearchAtherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States
Valero-Elizondo J, Chouairi F, Khera R, Grandhi GR, Saxena A, Warraich HJ, Virani SS, Desai NR, Sasangohar F, Krumholz HM, Esnaola NF, Nasir K. Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States. JACC CardioOncology 2021, 3: 236-246. PMID: 34396329, PMCID: PMC8352280, DOI: 10.1016/j.jaccao.2021.02.006.Peer-Reviewed Original ResearchCost-related medication nonadherenceFinancial toxicityMedication nonadherenceNational Health Interview SurveyAtherosclerotic cardiovascular diseaseMedical billsHealth Interview SurveyCancer careASCVDCardiovascular diseaseHigh burdenHigher oddsElderly populationCancerInterview SurveyFood insecurityCareNonadherenceSignificant proportionAdultsToxicityHigh financial distressPatientsPrevalenceDiseaseFinancial burden, distress, and toxicity in cardiovascular disease
Slavin SD, Khera R, Zafar SY, Nasir K, Warraich HJ. Financial burden, distress, and toxicity in cardiovascular disease. American Heart Journal 2021, 238: 75-84. PMID: 33961830, DOI: 10.1016/j.ahj.2021.04.011.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseFinancial burdenCommunity Health Worker IntegrationHigh-risk individualsComparative effectiveness studiesNon-medical needsHigh-cost interventionsHigh-cost treatmentsCVD managementEffectiveness studiesHealth systemPsychological distressInsurance coverageHealthcare policyBurdenDistressDiseaseSystem navigationInterventionCommunity-based initiativesPatientsPhysicians
2020
Prevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Prevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 1377-1386.e5. PMID: 32526341, PMCID: PMC7987215, DOI: 10.1016/j.cgh.2020.05.056.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseEmergency department useCost-related medicationFinancial toxicityBowel diseaseHealthcare useDepartment useSocial supportMedical billsInadequate social supportMultivariable analysisFood insecurityHigh financial toxicityPatientsFinancial hardshipSocial determinantsAbstractTextPopulation healthPrevalenceHealthcare deliveryMedicationsAdultsDiseaseFamily incomeToxicity
2014
“Inflammation and arterial stiffness in humans”
Jain S, Khera R, Corrales–Medina V, Townsend RR, Chirinos JA. “Inflammation and arterial stiffness in humans”. Atherosclerosis 2014, 237: 381-390. PMID: 25463062, DOI: 10.1016/j.atherosclerosis.2014.09.011.Peer-Reviewed Original ResearchConceptsPrimary inflammatory diseaseArterial stiffnessArterial stiffeningInflammatory diseasesPrimary inflammatory conditionsAnti-inflammatory interventionsRole of inflammationAnti-inflammatory therapyEffect of statinsEffects of inflammationPotential therapeutic targetCardiovascular morbiditySubclinical inflammationInflammatory conditionsGeneral populationTherapeutic targetInflammationEstablished markerNormal adultsPotential mechanismsDiseaseHypertensionMorbidityStatinsArtery
2011
Gender differences in the utilisation of surgery for congenital heart disease in India
Ramakrishnan S, Khera R, Jain S, Saxena A, Kailash S, Karthikeyan G, Kothari SS, Juneja R, Bhargava B, Kalaivani M, Mehta M, Bahl VK, Airan B. Gender differences in the utilisation of surgery for congenital heart disease in India. Heart 2011, 97: 1920. PMID: 21653217, DOI: 10.1136/hrt.2011.224410.Peer-Reviewed Original ResearchConceptsPediatric cardiac surgeryCongenital heart diseaseCardiac surgeryHeart diseaseFemale genderElective pediatric cardiac surgeryLow socioeconomic classConsecutive childrenIndependent predictorsProspective studyCorrective surgerySurgeryCardiac defectsEquitable careSocioeconomic classPatientsDiseaseSocial supportGirlsGender differencesChildrenImportant determinantInductive analytical approachYearsGender
2008
Complement Receptor 1: Disease associations and therapeutic implications
Khera R, Das N. Complement Receptor 1: Disease associations and therapeutic implications. Molecular Immunology 2008, 46: 761-772. PMID: 19004497, PMCID: PMC7125513, DOI: 10.1016/j.molimm.2008.09.026.Peer-Reviewed Original Research