2023
Developing synthetic tools to decipher the tumor–immune interactome
Weizman O, Luyten S, Lu P, Song E, Qin K, Mostaghimi D, Ring A, Iwasaki A. Developing synthetic tools to decipher the tumor–immune interactome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306632120. PMID: 37871202, PMCID: PMC10622925, DOI: 10.1073/pnas.2306632120.Peer-Reviewed Original ResearchConceptsImmune cellsImmune-based therapiesTumor-immune cell interactionsDifferent immunotherapiesRetroviral reportersSensitive tumorsImmune surveillanceTumor subtypesTumor microenvironmentSynthetic Notch receptorCell interactionsCell contactTissue functionTissue locationNotch receptorsVivoOptimal tissue functionCellsComprehensive landscapeImmunotherapyTherapyTumorsImmunogenicitySubtypes
2017
Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells
Wang Y, Shi J, Yan J, Xiao Z, Hou X, Lu P, Hou S, Mao T, Liu W, Ma Y, Zhang L, Yang X, Qi H. Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells. Nature Immunology 2017, 18: 921-930. PMID: 28650481, DOI: 10.1038/ni.3788.Peer-Reviewed Original Research
2013
Follicular T‐helper cells: controlled localization and cellular interactions
Qi H, Chen X, Chu C, Lu P, Xu H, Yan J. Follicular T‐helper cells: controlled localization and cellular interactions. Immunology And Cell Biology 2013, 92: 28-33. PMID: 24145857, DOI: 10.1038/icb.2013.59.Peer-Reviewed Original ResearchConceptsB cell responsesGerminal centersTfh cellsEffective antibody-based vaccineFollicular T helper cellsDependent B cell responsesIsotype-switched antibodiesAntibody-based vaccinesCD4 T cellsT helper cellsHumoral autoimmunityHumoral protectionT cellsTranscriptional repressor Bcl-6Surface phenotypeSuch antibodiesBCL-6Microbial infectionsGC reactionAntibodiesCellsCellular interactionsCurrent understandingHigh levelsAutoimmunityMicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation
Kang S, Liu W, Lu P, Jin H, Lim H, Shepherd J, Fremgen D, Verdin E, Oldstone M, Qi H, Teijaro J, Xiao C. MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation. Nature Immunology 2013, 14: 849-857. PMID: 23812097, PMCID: PMC3740954, DOI: 10.1038/ni.2648.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell DifferentiationFlow CytometryGerminal CenterImmunity, HumoralImmunohistochemistryInducible T-Cell Co-Stimulator ProteinLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroRNAsNuclear ProteinsPhosphatidylinositol 3-KinasesPhosphoprotein PhosphatasesSignal TransductionSpecific Pathogen-Free OrganismsT-Lymphocytes, Helper-Inducer