2024
Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing
Maayah M, Grubman S, Allen S, Ye Z, Park D, Vemmou E, Gokhan I, Sun W, Possick S, Kwan J, Gandhi P, Hu J. Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing. Diagnostics 2024, 14: 503. PMID: 38472975, PMCID: PMC10930800, DOI: 10.3390/diagnostics14050503.Peer-Reviewed Original ResearchAcute coronary syndromeTn elevationCoronary syndromeTreatment of acute coronary syndromesNon-cardiac etiologyManagement of myocardial injuryEvaluation of patientsHigh-sensitivity assaySerum troponinHighly sensitive testPrognostic implicationsCardiac troponinMyocardial injuryPhysical examMyocardial ischemiaPoor specificityLaboratory dataClinical judgmentClinical interpretationTroponinSyndromeAnalytical sensitivityTN measurementsPresentationElevationClinical Biochemistry of Serum Troponin
Gokhan I, Dong W, Grubman D, Mezue K, Yang D, Wang Y, Gandhi P, Kwan J, Hu J. Clinical Biochemistry of Serum Troponin. Diagnostics 2024, 14: 378. PMID: 38396417, PMCID: PMC10887818, DOI: 10.3390/diagnostics14040378.Peer-Reviewed Original ResearchAcute coronary syndromeFalse negative test resultsPoint of care assayInterpretation of serum levelsNegative test resultsTroponin complexChest painInterpretation of assay resultsSerum levelsClinical workupCoronary syndromeTn assaysMyocardial injuryTest characteristicsClinical settingCare assaysTroponinMeasurement assaysMolecular characteristicsPotential causesAssay resultsAssayMolecular structureFalse resultsConstituent proteins
2015
Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome
Huffman JC, Beale EE, Celano CM, Beach SR, Belcher AM, Moore SV, Suarez L, Motiwala SR, Gandhi PU, Gaggin HK, Januzzi JL. Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome. Circulation Cardiovascular Quality And Outcomes 2015, 9: 55-63. PMID: 26646818, PMCID: PMC4720551, DOI: 10.1161/circoutcomes.115.002184.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePhysical activityBaseline optimismCardiac readmissionACS patientsCoronary syndromeMultivariable Cox regressionSubsequent physical activityGreater physical activityMultivariable linear regressionBeneficial health outcomesPositive psychological constructsCardiac rehospitalizationCardiovascular outcomesMedical comorbiditiesClinical outcomesCox regressionACS outcomesPrognostic biomarkerHealth outcomesBaseline activityPsychological covariatesReadmissionBiomarkersEffects of optimismDesign and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study
Huffman JC, Beale EE, Beach SR, Celano CM, Belcher AM, Moore SV, Suarez L, Gandhi PU, Motiwala SR, Gaggin H, Januzzi JL. Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study. Contemporary Clinical Trials 2015, 44: 11-19. PMID: 26166171, PMCID: PMC4707130, DOI: 10.1016/j.cct.2015.07.002.Peer-Reviewed Original ResearchAcute coronary syndromeAcute Coronary Events (GRACE) studyOutcome measuresPhysical activityKey secondary outcome measuresFirst acute coronary syndromeSubsequent clinical outcomesSecondary outcome measuresPrimary outcome measureMultivariable linear regressionCardiac rehospitalizationCoronary syndromeCardiac outcomesClinical outcomesSubsequent rehospitalizationCox regressionMean ageCardiovascular healthPrognostic biomarkerPositive psychological constructsSuperior outcomesSame cohortGRACE studyNegative psychological factorsBaseline data