2019
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S. A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies. Nature Communications 2019, 10: 366. PMID: 30664659, PMCID: PMC6341122, DOI: 10.1038/s41467-018-08166-x.Peer-Reviewed Original ResearchConceptsPatient-derived xenograftsMyelodysplastic syndromeXenotransplantation modelDysplastic morphologyImmunodeficient murine hostsPre-clinical studiesMDS stem cellsMDS subtypesComprehensive preclinical studiesPreclinical studiesTherapeutic efficacyMurine hostSerial transplantationDrug mechanismsMDS researchStem cell propagationStem cellsDifferentiation potentialHematopoietic stem cell nicheGenetic complexityNovel avenuesStem cell nicheCell propagationDisease representationsImmunodeficient
2002
Human Keratinocytes Express Functional CD14 and Toll-Like Receptor 4
Song PI, Neparidze N, Armstrong C, Ansel J, Park Y, Abraham T, Harten B, Zivony A. Human Keratinocytes Express Functional CD14 and Toll-Like Receptor 4. Journal Of Investigative Dermatology 2002, 119: 424-432. PMID: 12190866, DOI: 10.1046/j.1523-1747.2002.01847.x.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Receptor 4Functional CD14Toll-like receptor 4 (TLR4) mRNAToll-like receptor 4 expressionBacterial infectionsRapid intracellular Ca2Receptor 4 expressionReceptor 4 mRNACutaneous innate immunityNuclear factor-kappaB nuclear translocationProinflammatory cytokinesCell surface expressionMyeloid cellsCD14Intracellular Ca2Innate immunityFlow cytometryNuclear translocationSurface expressionHuman keratinocytesInfectionKeratinocytesCellular responsesExpression