2021
Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program
Akwo EA, Robinson-Cohen C, Chung CP, Shah SC, Brown NJ, Ikizler TA, Wilson OD, Rowan BX, Shuey MM, Siew ED, Luther JM, Giri A, Hellwege JN, Edwards D, Roumie CL, Tao R, Tsao PS, Gaziano JM, Wilson PWF, O’Donnell C, Edwards TL, Kovesdy CP, Hung AM, Program O. Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program. Hypertension 2021, 78: 376-386. PMID: 34148359, PMCID: PMC8364328, DOI: 10.1161/hypertensionaha.120.16181.Peer-Reviewed Original Research
2020
Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema
Maroteau C, Siddiqui M, Veluchamy A, Carr F, White M, Cassidy AJ, Baranova EV, Rasmussen ER, Eriksson N, Bloch KM, Brown NJ, Bygum A, Hallberg P, Karawajczyk M, Magnusson PKE, Yue Q, Syvänen A, von Buchwald C, Alfirevic A, der Zee A, Wadelius M, Palmer CNA, PREDICTION‐ADR. Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema. Clinical Pharmacology & Therapeutics 2020, 108: 1195-1202. PMID: 32496628, PMCID: PMC10306231, DOI: 10.1002/cpt.1927.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioedemaAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCase-Control StudiesDNA Mutational AnalysisEuropeExomeExome SequencingFactor VFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedMutation RateMutation, MissenseRisk AssessmentRisk FactorsUnited StatesConceptsAngiotensin receptor blockersACEi-AEReceptor blockersLife-threatening adverse reactionsMissense variantsRare variantsCommon variantsRare missense variantsGene risk scoreACE inhibitorsAdverse reactionsDeleterious missense variantsHigh riskRisk scoreAngioedemaEnzyme inhibitorsNeck regionExome sequencingAsian populationsDifferent centersBlood clottingBlockersF5 geneRiskInhibitorsSkeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis
Gamboa JL, Roshanravan B, Towse T, Keller CA, Falck AM, Yu C, Frontera WR, Brown NJ, Ikizler TA. Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis. Clinical Journal Of The American Society Of Nephrology 2020, 15: 926-936. PMID: 32591419, PMCID: PMC7341789, DOI: 10.2215/cjn.10320819.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedDynaminsFemaleGlomerular Filtration RateHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedMitochondriaMuscle StrengthPhosphocreatinePhysical Functional PerformanceQuadriceps MuscleRenal DialysisRenal Insufficiency, ChronicSeverity of Illness IndexWalk TestConceptsMaintenance hemodialysisMarkers of inflammationAdipose tissue infiltrationOxidative stressPhysical performanceMitochondrial dysfunctionTissue infiltrationMitochondrial functionSkeletal muscle mitochondrial dysfunctionCKD stage 3Poor physical performanceSeverity of CKDMuscle mitochondrial dysfunctionIntermuscular adipose tissueSkeletal muscle biopsiesMagnetic resonance imagingWalk testHigh morbidityPhysical functionPhosphocreatine recoveryMultifactorial etiologyMuscle biopsyCKDHemodialysisPatientsIntraoperative Oxidative Damage and Delirium after Cardiac Surgery.
Lopez MG, Hughes CG, DeMatteo A, O’Neal J, McNeil JB, Shotwell MS, Morse J, Petracek MR, Shah AS, Brown NJ, Billings FT. Intraoperative Oxidative Damage and Delirium after Cardiac Surgery. Anesthesiology 2020, 132: 551-561. PMID: 31770146, PMCID: PMC7015795, DOI: 10.1097/aln.0000000000003016.Peer-Reviewed Original ResearchConceptsS100 calcium-binding protein BCalcium-binding protein BUbiquitin carboxyl-terminal hydrolase isozyme L1Blood-brain barrier disruptionNeuronal injuryPostoperative deliriumF2-isoprostanesBarrier disruptionOxidative damageConfusion Assessment MethodCardiac surgery patientsPostoperative day 1Intensive care unitBlood-brain barrierEnzyme-linked immunosorbentProtein BKidney injuryCohort studySurgery patientsCardiac surgeryTotal cohortCare unitIndependent associationClinical trialsPlasma concentrations
2018
Fish Oil and Perioperative Bleeding
Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, Tavazzi L, Latini R, Pretorius M, Brown NJ, Libby P, Mozaffarian D. Fish Oil and Perioperative Bleeding. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004584. PMID: 30571332, PMCID: PMC6376981, DOI: 10.1161/circoutcomes.118.004584.Peer-Reviewed Original ResearchConceptsBleeding Academic Research Consortium bleedingPerioperative bleedingFish oil supplementationFish oil groupLower riskPrimary outcomeFish oilMean ageOil supplementationOil groupBleeding Academic Research ConsortiumPlasma phospholipid omega-3Coronary artery bypass graftMajor perioperative bleedingChest tube outputPlacebo-controlled trialAcademic Research ConsortiumArtery bypass graftTreatment of hypertriglyceridemiaAbsolute risk differenceParticipants' mean ageHealth care professionalsFatty acid levelsBleeding definitionsHemostasis definitionEarly urine electrolyte patterns in patients with acute heart failure
Collins SP, Jenkins CA, Baughman A, Miller KF, Storrow AB, Han JH, Brown NJ, Liu D, Luther JM, McNaughton CD, Self WH, Peng D, Testani JM, Lindenfeld J. Early urine electrolyte patterns in patients with acute heart failure. ESC Heart Failure 2018, 6: 80-88. PMID: 30295437, PMCID: PMC6351901, DOI: 10.1002/ehf2.12368.Peer-Reviewed Original ResearchConceptsAcute heart failureDiuretic administrationDiuretic resistanceHeart failureLoop diureticsLow urinary sodiumEscalation of therapyUrine sodium excretionSubset of patientsSystolic blood pressureEmergency department patientsUrine sodium concentrationAHF diagnosisAHF patientsIntravenous diureticsUrinary sodiumED staySodium excretionUrinary electrolytesUrine sodiumNatriuretic responseStandard therapyBlood pressureDepartment patientsUrine outputAprepitant for the Treatment of Pruritus in Sézary Syndrome: A Randomized Crossover Clinical Trial
Zic JA, Straka BT, McGirt LY, Nian H, Yu C, Brown NJ. Aprepitant for the Treatment of Pruritus in Sézary Syndrome: A Randomized Crossover Clinical Trial. JAMA Dermatology 2018, 154: 1221-1222. PMID: 30140912, PMCID: PMC6233739, DOI: 10.1001/jamadermatol.2018.2510.Peer-Reviewed Original ResearchEndogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor–associated angioedema
Hubers S, Kohm K, Wei S, Yu C, Nian H, Grabert R, Sexton DJ, Brown NJ. Endogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor–associated angioedema. Journal Of Allergy And Clinical Immunology 2018, 142: 1636-1639.e5. PMID: 30036596, PMCID: PMC6226317, DOI: 10.1016/j.jaci.2018.06.037.Peer-Reviewed Original ResearchCharacteristics and treatment of African-American and European-American patients with resistant hypertension identified using the electronic health record in an academic health centre: a case−control study
Shuey MM, Gandelman JS, Chung CP, Nian H, Yu C, Denny JC, Brown NJ. Characteristics and treatment of African-American and European-American patients with resistant hypertension identified using the electronic health record in an academic health centre: a case−control study. BMJ Open 2018, 8: e021640. PMID: 29950471, PMCID: PMC6020960, DOI: 10.1136/bmjopen-2018-021640.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAdultAgedAngiotensin Receptor AntagonistsAntihypertensive AgentsBlack or African AmericanBlood PressureCalcium Channel BlockersCase-Control StudiesDiabetes Mellitus, Type 2Electronic Health RecordsFemaleHumansHypertensionLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrevalenceTennesseeWhite PeopleConceptsElectronic health recordsResistant hypertensionBlood pressureChronic kidney disease stage 3Mineralocorticoid receptor antagonist useClinical treatmentDihydropyridine calcium channel blockerAntihypertensive medication classesControlled blood pressureOutpatient blood pressureTotal hypertensive populationAngiotensin receptor blockersTransient ischemic attackDisease stage 3Health recordsMineralocorticoid receptor antagonistsReceptor antagonist useHigh blood pressureIschemic heart diseaseAlpha-2 agonistsBody mass indexCalcium channel blockersAfrican American patientsNumber of patientsType 2 diabetesFish Oil Supplementation Does Not Affect Cognitive Outcomes in Cardiac Surgery Patients in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial
Jackson JC, Mozaffarian D, Graves AJ, Brown NJ, Marchioli R, Kiehl AL, Ely EW. Fish Oil Supplementation Does Not Affect Cognitive Outcomes in Cardiac Surgery Patients in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial. Journal Of Nutrition 2018, 148: 472-479. PMID: 29546292, PMCID: PMC6454465, DOI: 10.1093/jn/nxx002.Peer-Reviewed Original ResearchConceptsOmega-3 fatty acidsCognitive declineCardiac surgeryTertiary care medical centerGlobal cognitionAtrial Fibrillation (ARISTOTLE) trialCardiac surgery patientsCardiac surgical patientsPostoperative cognitive declinePostoperative day 10Mini-Mental State ExamFatty acidsPerioperative supplementationPreoperative loadingPostcardiac surgeryHospital dischargeSurgery patientsSurgical patientsMedian agePrimary outcomePostoperative careUS patientsPUFA supplementationSurgery recipientsClinical trials
2017
Systolic Blood Pressure and Biochemical Assessment of Adherence
McNaughton CD, Brown NJ, Rothman RL, Liu D, Kabagambe EK, Levy PD, Self WH, Storrow AB, Collins SP, Roumie CL. Systolic Blood Pressure and Biochemical Assessment of Adherence. Hypertension 2017, 70: 307-314. PMID: 28652467, PMCID: PMC5531074, DOI: 10.1161/hypertensionaha.117.09659.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBiomarkersBlood PressureBlood Pressure DeterminationCross-Sectional StudiesEmergency Medical ServicesEmergency Service, HospitalFemaleHealth LiteracyHumansHypertensionMaleMass SpectrometryMedication AdherenceMedication Therapy ManagementMiddle AgedUnited StatesConceptsElevated blood pressureSystolic blood pressureBlood pressureSystolic BPEmergency departmentBiochemical assessmentAntihypertensive adherenceAdherent patientsLower systolic blood pressureAntihypertensive medication adherenceHigher systolic BPPrimary care providersBody mass indexCross-sectional studyAntihypertensive nonadherenceNonadherent patientsPrimary outcomeED careMedication nonadherenceMass indexMedication adherenceAcademic hospitalCare providersAntihypertensivesBlood assaysAssociation of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery
Shuey MM, Billings FT, Wei S, Milne GL, Nian H, Yu C, Brown NJ. Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery. PLOS ONE 2017, 12: e0175292. PMID: 28552948, PMCID: PMC5446112, DOI: 10.1371/journal.pone.0175292.Peer-Reviewed Original ResearchConceptsAcute kidney injuryChronic kidney diseaseCardiac surgery cohortSoluble epoxide hydrolaseCardiac surgeryKidney injurySurgery cohortAcute Kidney Injury Network criteriaIncidence of AKIPostoperative acute kidney injuryPercent of patientsGlomerular filtration rateBody mass indexAssociation of gainsRenal injuryCardiopulmonary bypassWhite patientsMass indexKidney diseaseFiltration ratePharmacological strategiesDiscovery cohortNetwork criteriaVariant carriersSEH activity
2016
Effect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema
Straka BT, Ramirez CE, Byrd JB, Stone E, Woodard-Grice A, Nian H, Yu C, Banerji A, Brown NJ. Effect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema. Journal Of Allergy And Clinical Immunology 2016, 140: 242-248.e2. PMID: 27913306, PMCID: PMC5705179, DOI: 10.1016/j.jaci.2016.09.051.Peer-Reviewed Original ResearchConceptsACE inhibitor-associated angioedemaResolution of symptomsVisual analog scaleAnalog scaleReceptor antagonistTreatment groupsBradykinin BEnzyme (ACE) inhibitor-associated angioedemaStudy drug administrationReceptor antagonist icatibantHours of presentationTreatment of attacksC1 inhibitor deficiencyBradykinin receptor antagonismFrequency of administrationVanderbilt University Medical CenterUniversity Medical CenterMassachusetts General HospitalTwo-thirdsAntagonist icatibantBowel edemaWhite patientsH2 blockersClinical efficacyInhibitor deficiencyCardiovascular Disease Risk Factors in Ghana during the Rural-to-Urban Transition: A Cross-Sectional Study
Kodaman N, Aldrich MC, Sobota R, Asselbergs FW, Poku KA, Brown NJ, Moore JH, Williams SM. Cardiovascular Disease Risk Factors in Ghana during the Rural-to-Urban Transition: A Cross-Sectional Study. PLOS ONE 2016, 11: e0162753. PMID: 27732601, PMCID: PMC5061429, DOI: 10.1371/journal.pone.0162753.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesCholesterolCholesterol, HDLCholesterol, LDLCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGhanaHumansHypertensionMaleMiddle AgedObesityPlasminogen Activator Inhibitor 1PrevalenceRisk FactorsSmokingSurveys and QuestionnairesTissue Plasminogen ActivatorTriglyceridesUrbanizationYoung AdultConceptsCardiovascular disease risk factorsDisease risk factorsRisk factorsUrban residenceWorse cardiovascular risk profileCardiovascular risk profileRelated clinical outcomesPopulation-based surveyCross-sectional studyFibrinolytic markersTotal cholesterolCholesterol profileClinical outcomesLDL cholesterolCardiovascular diseaseBMI adjustmentHigh riskRural participantsRisk profileLarger studyT-PAUrban womenUrban menObesityCholesterolB-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS
Semler MW, Marney AM, Rice TW, Nian H, Yu C, Wheeler AP, Brown NJ, Network N. B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS. CHEST Journal 2016, 150: 102-111. PMID: 27018313, PMCID: PMC4980545, DOI: 10.1016/j.chest.2016.03.017.Peer-Reviewed Original ResearchConceptsB-type natriuretic peptideAcute respiratory distress syndromeConservative fluid managementRespiratory distress syndromeLiberal fluid managementVentilator-free daysNatriuretic peptideFluid managementDistress syndromeAldosterone concentrationOverall mortalityB-type natriuretic peptide concentrationsCatheter Treatment TrialNatriuretic peptide concentrationsLow aldosterone concentrationsHospital mortalityMedian aldosteroneMultivariable analysisStudy enrollmentTreatment trialsPlasma concentrationsRetrospective analysisFluid balanceAldosteroneFluid strategyHigh-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial
Billings FT, Hendricks PA, Schildcrout JS, Shi Y, Petracek MR, Byrne JG, Brown NJ. High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial. JAMA 2016, 315: 877. PMID: 26906014, PMCID: PMC4843765, DOI: 10.1001/jama.2016.0548.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overAspartate AminotransferasesAtorvastatinCardiac Surgical ProceduresCreatinineDouble-Blind MethodDrug Administration ScheduleFemaleGlomerular Filtration RateHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMedication AdherenceMiddle AgedPostoperative ComplicationsRenal Insufficiency, ChronicConceptsAcute kidney injuryMorning of surgerySerum creatinine concentrationPlacebo groupCardiac surgeryStatin treatmentAtorvastatin groupKidney injuryClinical trialsCreatinine concentrationAcute Kidney Injury Following Cardiac SurgeryAdult cardiac surgery patientsCardiac surgery patientsChronic kidney diseaseHours of surgeryPostoperative day 2Day of surgerySafety monitoring boardVanderbilt University Medical CenterUniversity Medical CenterAtorvastatin dailyStatin therapyAtorvastatin treatmentSurgery patientsKidney disease
2014
Hypertension Is Associated With Preamyloid Oligomers in Human Atrium: A Missing Link in Atrial Pathophysiology?
Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su P, Shyr Y, Atkinson JB, Fogo AB, Prinsen JK, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT. Hypertension Is Associated With Preamyloid Oligomers in Human Atrium: A Missing Link in Atrial Pathophysiology? Journal Of The American Heart Association 2014, 3: e001384. PMID: 25468655, PMCID: PMC4338732, DOI: 10.1161/jaha.114.001384.Peer-Reviewed Original ResearchConceptsAtrial samplesAtrial amyloidosisMitral valve replacement/repairValve replacement/repairCoronary Artery Bypass GraftingHuman atriumArtery Bypass GraftingElective cardiac surgeryAortic valve replacementPresence of hypertensionCongestive heart failureCoronary artery diseaseAtrial natriuretic peptideReplacement/repairAtrial pathophysiologyBypass GraftingClinical hypertensionMost patientsValve replacementArtery diseaseCardiac surgeryHeart failureNatriuretic peptideAtrial arrhythmiasMean ageGenetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans
Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ. Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. International Journal Of Cardiology Cardiovascular Risk And Prevention 2014, 8: 475-480. PMID: 25064769, PMCID: PMC4115247, DOI: 10.1016/j.jash.2014.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlack or African AmericanBlood PressureCytochrome P-450 CYP4ACytochrome P-450 Enzyme SystemDNADouble-Blind MethodFemaleGenetic VariationGenotypeHumansHypertensionMaleMiddle AgedMineralocorticoid Receptor AntagonistsPilot ProjectsRadioimmunoassayUnited StatesYoung AdultConceptsBlood pressure responseBlood pressureReceptor antagonismPressure responseMineralocorticoid receptor antagonismSalt-sensitive hypertensionAfrican AmericansExploratory pilot studyGC individualsAldosterone responseResistant hypertensionAntihypertensive effectTreatment responsePrecluded analysisCC genotypeCC homozygotesSpironolactoneC alleleHypertensionPilot studyENaC activationCYP4A11AmilorideActivation of ENaC.ENaC inhibition
2013
Plasma Phospholipid Omega‐3 Fatty Acids and Incidence of Postoperative Atrial Fibrillation in the OPERA Trial
Wu JH, Marchioli R, Silletta MG, Macchia A, Song X, Siscovick DS, Harris WS, Masson S, Latini R, Albert C, Brown NJ, Lamarra M, Favaloro RR, Mozaffarian D. Plasma Phospholipid Omega‐3 Fatty Acids and Incidence of Postoperative Atrial Fibrillation in the OPERA Trial. Journal Of The American Heart Association 2013, 2: e000397. PMID: 24145742, PMCID: PMC3835252, DOI: 10.1161/jaha.113.000397.Peer-Reviewed Original ResearchConceptsFish oil supplementationMorning of surgeryPostoperative atrial fibrillationCardiac surgeryOil supplementationDocosapentaenoic acidAtrial fibrillationDocosahexaenoic acidEicosapentaenoic acidShort-term fish oil supplementationPUFA levelsOmega-3 fatty acidsCardiac surgery patientsPlasma phospholipid nPostoperative day 10Substantial interindividual variabilityOPERA trialPoAF episodesPlacebo supplementationPrimary endpointSecondary endpointsHospital dischargeSurgery patientsAntiarrhythmic potentialFatty acidsPollen Count and Presentation of Angiotensin-Converting Enzyme Inhibitor–Associated Angioedema
Straka B, Nian H, Sloan C, Byrd JB, Woodard-Grice A, Yu C, Stone E, Steven G, Hartert T, Teo KK, Pare G, McCarty CA, Brown NJ. Pollen Count and Presentation of Angiotensin-Converting Enzyme Inhibitor–Associated Angioedema. The Journal Of Allergy And Clinical Immunology In Practice 2013, 1: 468-473.e4. PMID: 24565618, PMCID: PMC4042396, DOI: 10.1016/j.jaip.2013.05.003.Peer-Reviewed Original ResearchConceptsACE inhibitor-associated angioedemaRate of angioedemaSeasonal allergiesRamipril Global Endpoint TrialAngiotensin converting enzyme (ACE) inhibitorsEnzyme (ACE) inhibitor-associated angioedemaIncidence of angiotensinMonths of presentationAdverse drug eventsDate of presentationVanderbilt University Medical CenterUniversity Medical CenterMarshfield Clinic Personalized Medicine Research ProjectOngoing TelmisartanEndpoint trialsACE inhibitorsPollen countsDrug eventsAssociated angioedemaObservational studyCohort analysisMedical CenterHospital settingAngioedemaPersonalized Medicine Research Project