2016
Response by Hubers and Brown to Letter Regarding Article, “Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition”
Hubers SA, Brown NJ. Response by Hubers and Brown to Letter Regarding Article, “Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition”. Circulation 2016, 134: e11-e12. PMID: 27436883, PMCID: PMC4957697, DOI: 10.1161/circulationaha.116.023311.Peer-Reviewed Original Research
1997
Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant
Gainer J, Hunley T, Kon V, Nadeau J, Muldowney J, Brown N. Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant. IUBMB Life 1997, 43: 227-231. PMID: 9315301, DOI: 10.1080/15216549700204001.Peer-Reviewed Original ResearchConceptsC1166 variantAngiotensin II type I receptorAfrican AmericansNormotensive African AmericansType I receptorReceptor polymorphismsAfrican American populationCaucasian subjectsI receptorSubstitution polymorphismCaucasiansAmerican populationHypertensionLow frequencyPolymorphismAmericansVariantsReceptors
1996
Angiotensin converting enzyme gene polymorphism: Potential silencer motif and impact on progression in IgA nephropathy
Hunley T, Julian B, Phillips J, Summar M, Yoshida H, Horn R, Brown N, Fogo A, Ichikawa I, Kon V. Angiotensin converting enzyme gene polymorphism: Potential silencer motif and impact on progression in IgA nephropathy. Kidney International 1996, 49: 571-577. PMID: 8821846, DOI: 10.1038/ki.1996.81.Peer-Reviewed Original ResearchConceptsRenin-angiotensin systemIgA nephropathyRenal functionDD genotypeMyocardial infarctionCardiovascular diseaseACE genotype frequenciesGene polymorphismsBiopsy-proven IgA nephropathyACE I/D polymorphismAGT 235TEnzyme deletion polymorphismNormal serum creatinineRenal disease progressionACE DD genotypeEnzyme gene polymorphismGenotype frequenciesI gene polymorphismStable creatinineAngiotensin systemSerum creatinineRenal statusVentricular hypertrophyCaucasian patientsRisk factors