2001
Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity
Gainer JV, Stein CM, Neal T, Vaughan DE, Brown NJ. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension 2001, 37: 46-51. PMID: 11208755, DOI: 10.1161/01.hyp.37.1.46.Peer-Reviewed Original ResearchACE insertion/deletion polymorphismGreater vasodilator responseVasodilator responseACE D alleleSodium nitroprussideInsertion/deletion polymorphismVascular reactivityEndothelium-independent vasodilator sodium nitroprussideD allelePotent endothelium-dependent vasodilatorVascular smooth muscle reactivityACE I/D genotypeEffect of angiotensinForearm blood flowSmooth muscle reactivityEndothelium-dependent vasodilatorVasodilator sodium nitroprussideDeletion polymorphismTreatment of hypertensionACE gene locusVascular sensitivityNormotensive subjectsNormotensive blacksVenous plethysmographyBlood pressure
2000
Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Modulates the Human In Vivo Metabolism of Bradykinin
Murphey L, Gainer J, Vaughan D, Brown N. Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Modulates the Human In Vivo Metabolism of Bradykinin. Circulation 2000, 102: 829-832. PMID: 10952948, DOI: 10.1161/01.cir.102.8.829.Peer-Reviewed Original ResearchConceptsPlasma ACE activityACE activityInsertion/deletion polymorphismD genotypeD alleleBK1-5ACE I/D polymorphismEnzyme insertion/deletion polymorphismAngiotensin-Converting Enzyme Insertion/Deletion PolymorphismTissue plasminogen activator releaseAngiotensin II productionDeletion polymorphismTissue ACE activityACE D alleleACE I/IPlasminogen activator releaseFmol/mLPlasma ACE levelsBradykinin metabolismBrachial arteryVenous returnCardioprotective peptideKinin concentrationsACE levelsBradykinin concentrations