A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, AlMazroa M, Amann M, Anderson H, Andrews K, Aryee M, Atkinson C, Bacchus L, Bahalim A, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell M, Blore J, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce N, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett R, Byers T, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen J, Cheng A, Child J, Cohen A, Colson K, Cowie B, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Jarlais D, Devries K, Dherani M, Ding E, Dorsey E, Driscoll T, Edmond K, Ali S, Engell R, Erwin P, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane M, Flaxman S, Fowkes F, Freedman G, Freeman M, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez H, Hall W, Hoek H, Hogan A, Hosgood H, Hoy D, Hu H, Hubbell B, Hutchings S, Ibeanusi S, Jacklyn G, Jasrasaria R, Jonas J, Kan H, Kanis J, Kassebaum N, Kawakami N, Khang Y, Khatibzadeh S, Khoo J, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher J, Leigh J, Li Y, Lin J, Lipshultz S, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Memish Z, Mensah G, Merriman T, Micha R, Michaud C, Mishra V, Hanafiah K, Mokdad A, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson P, Nolla J, Norman R, Olives C, Omer S, Orchard J, Osborne R, Ostro B, Page A, Pandey K, Parry C, Passmore E, Patra J, Pearce N, Pelizzari P, Petzold M, Phillips M, Pope D, Pope C, Powles J, Rao M, Razavi H, Rehfuess E, Rehm J, Ritz B, Rivara F, Roberts T, Robinson C, Rodriguez-Portales J, Romieu I, Room R, Rosenfeld L, Roy A, Rushton L, Salomon J, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh G, Sleet D, Smith E, Smith K, Stapelberg N, Steenland K, Stöckl H, Stovner L, Straif K, Straney L, Thurston G, Tran J, Van Dingenen R, van Donkelaar A, Veerman J, Vijayakumar L, Weintraub R, Weissman M, White R, Whiteford H, Wiersma S, Wilkinson J, Williams H, Williams W, Wilson N, Woolf A, Yip P, Zielinski J, Lopez A, Murray C, Ezzati M. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 2012, 380: 2224-2260. PMID: 23245609, PMCID: PMC4156511, DOI: 10.1016/s0140-6736(12)61766-8.Peer-Reviewed Original ResearchConceptsSecond-hand smokeDisease Study 2010High blood pressureRisk factorsDisease burdenGlobal disease burdenTobacco smokingRisk factor exposureBlood pressureGlobal DALYsChildhood underweightRelative riskGlobal burdenStudy 2010Unimproved waterCommunicable diseasesHigher body mass indexHigh-income North AmericaAlcohol useChildhood communicable diseasesDisability-adjusted life yearsRisk factor clustersDietary risk factorsCause-specific deathBody mass indexYears lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, AlMazroa M, Alvarado M, Anderson H, Anderson L, Andrews K, Atkinson C, Baddour L, Bahalim A, Barker-Collo S, Barrero L, Bartels D, Basáñez M, Baxter A, Bell M, Benjamin E, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black J, Blencowe H, Blore J, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha T, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke C, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter C, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng A, Chou D, Chugh S, Coffeng L, Colan S, Colquhoun S, Colson K, Condon J, Connor M, Cooper L, Corriere M, Cortinovis M, de Vaccaro K, Couser W, Cowie B, Criqui M, Cross M, Dabhadkar K, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Jarlais D, Dharmaratne S, Dherani M, Diaz-Torne C, Dolk H, Dorsey E, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali S, Erskine H, Erwin P, Espindola P, Ewoigbokhan S, Farzadfar F, Feigin V, Felson D, Ferrari A, Ferri C, Fèvre E, Finucane M, Flaxman S, Flood L, Foreman K, Forouzanfar M, Fowkes F, Franklin R, Fransen M, Freeman M, Gabbe B, Gabriel S, Gakidou E, Ganatra H, Garcia B, Gaspari F, Gillum R, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa Y, Hall W, Haring D, Haro J, Harrison J, Havmoeller R, Hay R, Higashi H, Hill C, Hoen B, Hoffman H, Hotez P, Hoy D, Huang J, Ibeanusi S, Jacobsen K, James S, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas J, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo J, King C, Knowlton L, Kobusingye O, Koranteng A, Krishnamurthi R, Lalloo R, Laslett L, Lathlean T, Leasher J, Lee Y, Leigh J, Lim S, Limb E, Lin J, Lipnick M, Lipshultz S, Liu W, Loane M, Ohno S, Lyons R, Ma J, Mabweijano J, MacIntyre M, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis D, Marks G, Marks R, Matsumori A, Matzopoulos R, Mayosi B, McAnulty J, McDermott M, McGill N, McGrath J, Medina-Mora M, Meltzer M, Memish Z, Mensah G, Merriman T, Meyer A, Miglioli V, Miller M, Miller T, Mitchell P, Mocumbi A, Moffitt T, Mokdad A, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch M, Mwaniki M, Naidoo K, Nair M, Naldi L, Narayan K, Nelson P, Nelson R, Nevitt M, Newton C, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer S, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian J, Rivero A, Patten S, Pearce N, Padilla R, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips M, Pierce K, Pion S, Polanczyk G, Polinder S, Pope C, Popova S, Porrini E, Pourmalek F, Prince M, Pullan R, Ramaiah K, Ranganathan D, Razavi H, Regan M, Rehm J, Rein D, Remuzzi G, Richardson K, Rivara F, Roberts T, Robinson C, De Leòn F, Ronfani L, Room R, Rosenfeld L, Rushton L, Sacco R, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel D, Scott J, Segui-Gomez M, Shahraz S, Shepard D, Shin H, Shivakoti R, Silberberg D, Singh D, Singh G, Singh J, Singleton J, Sleet D, Sliwa K, Smith E, Smith J, Stapelberg N, Steer A, Steiner T, Stolk W, Stovner L, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor H, Taylor J, Taylor W, Thomas B, Thomson W, Thurston G, Tleyjeh I, Tonelli M, Towbin J, Truelsen T, Tsilimbaris M, Ubeda C, Undurraga E, van der Werf M, van Os J, Vavilala M, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall D, Weinstock M, Weintraub R, Weisskopf M, Weissman M, White R, Whiteford H, Wiersma S, Wilkinson J, Williams H, Williams S, Witt E, Wolfe F, Woolf A, Wulf S, Yeh P, Zaidi A, Zheng Z, Zonies D, Lopez A, Murray C. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 2012, 380: 2163-2196. PMID: 23245607, PMCID: PMC6350784, DOI: 10.1016/s0140-6736(12)61729-2.Peer-Reviewed Original ResearchConceptsNon-fatal health outcomesHealth outcomesHealth systemGlobal burdenMusculoskeletal disordersBayesian meta-regression methodChronic obstructive pulmonary diseasePopulation-based cancer registriesCauses of YLDsRate of YLDsHealth lossObstructive pulmonary diseaseDisease Study 2010Ambulatory care dataLow back painHospital discharge dataAge-specific prevalenceIron deficiency anemiaMajor depressive disorderBehavioral disordersDescriptive epidemiological dataLarge methodological variationNatural history modelYears of lifeHIV/AIDSDisability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, AlMazroa M, Alvarado M, Anderson H, Anderson L, Andrews K, Atkinson C, Baddour L, Bahalim A, Barker-Collo S, Barrero L, Bartels D, Basáñez M, Baxter A, Bell M, Benjamin E, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black J, Blencowe H, Blore J, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha T, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke C, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter C, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng A, Chou D, Chugh S, Coffeng L, Colan S, Colquhoun S, Colson K, Condon J, Connor M, Cooper L, Corriere M, Cortinovis M, de Vaccaro K, Couser W, Cowie B, Criqui M, Cross M, Dabhadkar K, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Jarlais D, Dharmaratne S, Dherani M, Diaz-Torne C, Dolk H, Dorsey E, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali S, Erskine H, Erwin P, Espindola P, Ewoigbokhan S, Farzadfar F, Feigin V, Felson D, Ferrari A, Ferri C, Fèvre E, Finucane M, Flaxman S, Flood L, Foreman K, Forouzanfar M, Fowkes F, Fransen M, Freeman M, Gabbe B, Gabriel S, Gakidou E, Ganatra H, Garcia B, Gaspari F, Gillum R, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa Y, Hall W, Haring D, Haro J, Harrison J, Havmoeller R, Hay R, Higashi H, Hill C, Hoen B, Hoffman H, Hotez P, Hoy D, Huang J, Ibeanusi S, Jacobsen K, James S, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas J, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo J, King C, Knowlton L, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett L, Lathlean T, Leasher J, Lee Y, Leigh J, Levinson D, Lim S, Limb E, Lin J, Lipnick M, Lipshultz S, Liu W, Loane M, Ohno S, Lyons R, Mabweijano J, MacIntyre M, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis D, Marks G, Marks R, Matsumori A, Matzopoulos R, Mayosi B, McAnulty J, McDermott M, McGill N, McGrath J, Medina-Mora M, Meltzer M, Memish Z, Mensah G, Merriman T, Meyer A, Miglioli V, Miller M, Miller T, Mitchell P, Mock C, Mocumbi A, Moffitt T, Mokdad A, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch M, Mwaniki M, Naidoo K, Nair M, Naldi L, Narayan K, Nelson P, Nelson R, Nevitt M, Newton C, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer S, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian J, Rivero A, Patten S, Pearce N, Padilla R, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips M, Pierce K, Pion S, Polanczyk G, Polinder S, Pope C, Popova S, Porrini E, Pourmalek F, Prince M, Pullan R, Ramaiah K, Ranganathan D, Razavi H, Regan M, Rehm J, Rein D, Remuzzi G, Richardson K, Rivara F, Roberts T, Robinson C, De Leòn F, Ronfani L, Room R, Rosenfeld L, Rushton L, Sacco R, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel D, Scott J, Segui-Gomez M, Shahraz S, Shepard D, Shin H, Shivakoti R, Silberberg D, Singh D, Singh G, Singh J, Singleton J, Sleet D, Sliwa K, Smith E, Smith J, Stapelberg N, Steer A, Steiner T, Stolk W, Stovner L, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor H, Taylor J, Taylor W, Thomas B, Thomson W, Thurston G, Tleyjeh I, Tonelli M, Towbin J, Truelsen T, Tsilimbaris M, Ubeda C, Undurraga E, van der Werf M, van Os J, Vavilala M, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall D, Weinstock M, Weintraub R, Weisskopf M, Weissman M, White R, Whiteford H, Wiebe N, Wiersma S, Wilkinson J, Williams H, Williams S, Witt E, Wolfe F, Woolf A, Wulf S, Yeh P, Zaidi A, Zheng Z, Zonies D, Lopez A. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 2012, 380: 2197-2223. PMID: 23245608, DOI: 10.1016/s0140-6736(12)61689-4.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsGlobal disability-adjusted life yearsDisease burdenNon-communicable diseasesGlobal burdenDisability weightsCrude disability-adjusted life yearLife yearsCauses of DALYsNew disability weightsLower respiratory infectionsDisease Study 2010Ischemic heart diseaseSum of yearsNutritional disordersCause-specific mortalityMajor depressive disorderGlobal disease burdenHIV/AIDSContribution of deathsCause mortalityRespiratory infectionsSaharan AfricaInjury burdenHeart disease