A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.
Josien R, Douillard P, Guillot C, Müschen M, Anegon I, Chetritt J, Menoret S, Vignes C, Soulillou J, Cuturi M. A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. Journal Of Clinical Investigation 1998, 102: 1920-1926. PMID: 9835616, PMCID: PMC509143, DOI: 10.1172/jci4221.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBlood TransfusionGraft Enhancement, ImmunologicGraft RejectionGraft SurvivalHeart TransplantationLeukocytesLymphocyte Culture Test, MixedMaleRatsRats, Inbred BUFRats, Inbred LewRNA, MessengerSpleenTissue DonorsTransforming Growth Factor betaTransplantation, HomologousConceptsAllograft toleranceHeart allograft toleranceNonspecific blood transfusionsProlonged graft survivalTh2-related cytokinesTGF-beta1 mRNALater time pointsGraft survivalAllograft rejectionHeart allograftsImmunological mechanismsBlood transfusionRegulatory cellsDonor-SpecificUnmodified recipientsAdult ratsCritical cytokineStrong infiltrationAllograftsTime pointsRecombinant adenovirusCytokinesGraftRatsLeukocytesFas LIGAND, TUMOR NECROSIS FACTOR-α EXPRESSION, AND APOPTOSIS DURING ALLOGRAFT REJECTION AND TOLERANCE
Josien R, Müschen M, Gilbert E, Douillard P, Heslan J, Soulillou J, Cuturi M. Fas LIGAND, TUMOR NECROSIS FACTOR-α EXPRESSION, AND APOPTOSIS DURING ALLOGRAFT REJECTION AND TOLERANCE. Transplantation 1998, 66: 887-893. PMID: 9798699, DOI: 10.1097/00007890-199810150-00013.Peer-Reviewed Original ResearchConceptsAllograft rejectionTNF-alphaDonor-specific blood transfusionApoptotic cellsNecrosis factor α expressionRole of CD95LAcute allograft rejectionDonor-specific transfusionGraft-infiltrating cellsHeterotopic cardiac allograftsCytotoxic T cellsTarget cell lysisTNF-alpha expressionTumor necrosis factorExpression of CD95LCD95/CD95LExpression of FasAcute rejectionCardiac allograftsBlood transfusionIntragraft expressionNecrosis factorT cellsCD95 antigenAllografts