2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2023
Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report
Miller C, Taylor-Salmon E, Emuren L, Landry M, Gershon A, Miller G. Progressive shingles in a toddler due to reactivation of Varicella Zoster vaccine virus four days after infection with SARS-CoV-2; a case report. BMC Infectious Diseases 2023, 23: 854. PMID: 38057696, PMCID: PMC10698951, DOI: 10.1186/s12879-023-08809-5.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVZV reactivationVaccine-strain varicella-zoster virusSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Latent varicella zoster virusSymptomatic COVID-19 infectionRespiratory syndrome coronavirus 2SARS-CoV2 infectionSyndrome coronavirus 2COVID-19 infectionVaccine-type strainsSARS-CoV-2Vesicular rashPediatric patientsSignificant morbidityClinical syndromeCoronavirus 2Single doseCase reportGeneral populationMechanical traumaDisease processHZ casesPhysiologic stress
2013
Comparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens
Gitman MR, Ferguson D, Landry ML. Comparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens. Journal Of Clinical Microbiology 2013, 51: 3765-3769. PMID: 24006008, PMCID: PMC3889765, DOI: 10.1128/jcm.01413-13.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overChildChild, PreschoolClinical Laboratory TechniquesCosts and Cost AnalysisFemaleFluorescent Antibody TechniqueHerpes SimplexHumansInfantInfant, NewbornMaleMiddle AgedPolymerase Chain ReactionSensitivity and SpecificitySimplexvirusTime FactorsVirus CultivationYoung Adult
2011
Diagnostic tests for influenza infection
Landry ML. Diagnostic tests for influenza infection. Current Opinion In Pediatrics 2011, 23: 91-97. PMID: 21150446, DOI: 10.1097/mop.0b013e328341ebd9.Peer-Reviewed Original ResearchConceptsMolecular testingMultiplex molecular testRapid antigen testInfluenza infectionViral loadAntigen testPatient groupSeasonal influenzaImmunofluorescence testDiagnostic test performanceAntigenic changesNext pandemicRapid cultureDiagnostic testsMolecular testsMarked variabilityNegative resultsSame testDiagnostic methods
2009
Cytospin-Enhanced Immunofluorescence and Impact of Sample Quality on Detection of Novel Swine Origin (H1N1) Influenza Virus
Landry ML, Ferguson D. Cytospin-Enhanced Immunofluorescence and Impact of Sample Quality on Detection of Novel Swine Origin (H1N1) Influenza Virus. Journal Of Clinical Microbiology 2009, 48: 957-959. PMID: 20042632, PMCID: PMC2832425, DOI: 10.1128/jcm.01678-09.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsChildChild, PreschoolClinical Laboratory TechniquesFluorescent Antibody Technique, DirectHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanNasopharynxReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityVirologyYoung AdultConceptsNovel swine-origin influenza virusesSwine-origin influenza virusImmunofluorescence antibody testingReal-time reverse transcriptase PCRCycle threshold valuesPCR-positive resultsPediatric patientsCDC assayAntibody testingNasopharyngeal swabsReverse transcriptase-PCRSwine influenzaInfluenza virusTranscriptase-PCRPositive samplesPatientsPositive resultsInfluenzaSwabsCytospinsEmergent US adenovirus 3 strains associated with an epidemic and serious disease
Lebeck MG, McCarthy TA, Capuano AW, Schnurr DP, Landry ML, Setterquist SF, Heil GL, Kilic S, Gray GC. Emergent US adenovirus 3 strains associated with an epidemic and serious disease. Journal Of Clinical Virology 2009, 46: 331-336. PMID: 19854101, PMCID: PMC2806089, DOI: 10.1016/j.jcv.2009.09.023.Peer-Reviewed Original ResearchConceptsClinical diseaseSevere diseaseSevere clinical diseaseYears of ageRisk factor modelingRisk factorsChronic diseasesAdenovirus type 3Emergent strainsPrevalent serotypesHAdV3DiseaseMultivariate modelingType 3Serious diseaseRare strainsNovel variantsRestriction enzyme analysisAdenovirus 3Genomic characterizationEnzyme analysisStatistical analysisUS laboratoriesPersonsVariantsAdenovirus type 3 outbreak in connecticut associated with a novel variant
Landry ML, Lebeck MG, Capuano AW, McCarthy T, Gray GC. Adenovirus type 3 outbreak in connecticut associated with a novel variant. Journal Of Medical Virology 2009, 81: 1380-1384. PMID: 19551823, PMCID: PMC2897138, DOI: 10.1002/jmv.21539.Peer-Reviewed Original Research
2008
An Outbreak of Concurrent Echovirus 30 and Coxsackievirus A1 Infections Associated with Sea Swimming among a Group of Travelers to Mexico
Begier EM, Oberste MS, Landry ML, Brennan T, Mlynarski D, Mshar PA, Frenette K, Rabatsky-Ehr T, Purviance K, Nepaul A, Nix WA, Pallansch MA, Ferguson D, Cartter ML, Hadler JL. An Outbreak of Concurrent Echovirus 30 and Coxsackievirus A1 Infections Associated with Sea Swimming among a Group of Travelers to Mexico. Clinical Infectious Diseases 2008, 47: 616-623. PMID: 18637756, DOI: 10.1086/590562.Peer-Reviewed Original ResearchConceptsEchovirus 30Enteroviral infectionNucleic acid amplification testingIllness onset datesUninfected control subjectsPoint-source exposureMultiple enterovirusesAseptic meningitisFrequent symptomsIllness onsetViral cultureAmplification testingControl subjectsCerebrospinal fluidHuman stoolInfectionNauseaConnecticut DepartmentStoolCoxsackievirus (CV) A1Public healthIllnessEnterovirusesMolecular amplificationGroups of travelersReal-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients
Landry ML, Cohen S, Ferguson D. Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients. Journal Of Clinical Virology 2008, 43: 148-151. PMID: 18639488, PMCID: PMC7173065, DOI: 10.1016/j.jcv.2008.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntibodies, MonoclonalChildChild, PreschoolFluorescent Antibody Technique, DirectHospitalizationHumansImmunoassayInfantInfluenza A virusInfluenza B virusInfluenza, HumanMiddle AgedNasopharynxReagent Kits, DiagnosticReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityTaq PolymeraseTime FactorsVirus CultivationYoung AdultConceptsHospitalized patientsTaqMan RT-PCRRT-PCRInfluenza ARapid flu testsDiagnosis of influenzaInfluenza-positive samplesDetection of influenzaReal-time RT-PCRInfluenza BInfluenza diagnosisPatient managementReal-time PCRMore accurate testsPatientsBinaxTrue positive samplesRapid testClinical samplesPositive samplesFurther studiesHospitalAccurate testInfluenzaDiagnosisProspective Study of Human Metapneumovirus Detection in Clinical Samples by Use of Light Diagnostics Direct Immunofluorescence Reagent and Real-Time PCR
Landry ML, Cohen S, Ferguson D. Prospective Study of Human Metapneumovirus Detection in Clinical Samples by Use of Light Diagnostics Direct Immunofluorescence Reagent and Real-Time PCR. Journal Of Clinical Microbiology 2008, 46: 1098-1100. PMID: 18184854, PMCID: PMC2268359, DOI: 10.1128/jcm.01926-07.Peer-Reviewed Original Research
2007
Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006
Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006. Clinical Infectious Diseases 2007, 45: 1120-1131. PMID: 17918073, PMCID: PMC2064001, DOI: 10.1086/522188.Peer-Reviewed Original ResearchConceptsAdenovirus infectionIntensive care unit staySolid organ transplantationChronic disease conditionsAdenovirus isolatesUnited States 2004Adenovirus-positive specimensRisk factor modelingTyping methodsUnit stayRisk factorsAntigenic presentationChronic diseasesGenotype prevalenceClinical dataOrgan transplantationSevere diseaseRecent transplantationBone marrowBlinded comparisonDisease severityMilitary traineesSequence typing methodInfectionCancer diagnosisSerum IgA Antibodies to Epstein-Barr Virus (EBV) Early Lytic Antigens Are Present in Primary EBV Infection
Bhaduri-McIntosh S, Landry ML, Nikiforow S, Rotenberg M, El-Guindy A, Miller G. Serum IgA Antibodies to Epstein-Barr Virus (EBV) Early Lytic Antigens Are Present in Primary EBV Infection. The Journal Of Infectious Diseases 2007, 195: 483-492. PMID: 17230407, DOI: 10.1086/510916.Peer-Reviewed Original ResearchConceptsPrimary EBV infectionSerum IgA antibodiesIgA antibodiesEBV infectionLytic antigensPrimary infectionPrimary Epstein-Barr virus infectionHealthy EBV-seropositive individualsEpstein-Barr virus infectionEB nuclear antigenEBV-seropositive individualsViral capsid antigenAbsence of antibodiesFlow cytometry-based assayLytic EBV replicationCytometry-based assayBurkitt's lymphoma cellsCapsid antigenMucosal sitesEBV replicationIgM antibodiesVirus infectionInfectionLymphoma cellsSerum samples
2005
Real-Time Nucleic Acid Sequence-Based Amplification Using Molecular Beacons for Detection of Enterovirus RNA in Clinical Specimens
Landry ML, Garner R, Ferguson D. Real-Time Nucleic Acid Sequence-Based Amplification Using Molecular Beacons for Detection of Enterovirus RNA in Clinical Specimens. Journal Of Clinical Microbiology 2005, 43: 3136-3139. PMID: 16000425, PMCID: PMC1169110, DOI: 10.1128/jcm.43.7.3136-3139.2005.Peer-Reviewed Original ResearchConceptsNucleic acid sequence-based amplificationTime Nucleic Acid Sequence-Based AmplificationEV-positive samplesReal-time nucleic acid sequence-based amplificationDetection of enterovirusesEnterovirus RNAStool samplesCerebrospinal fluidNASBA assayClinical specimensEnterovirusesMolecular beacon technologyAssaysHerpes simplex virus Type 2 Acute Retinal Necrosis 9 Years after Neonatal Herpes
Landry ML, Mullangi P, Nee P, Klein BR. Herpes simplex virus Type 2 Acute Retinal Necrosis 9 Years after Neonatal Herpes. The Journal Of Pediatrics 2005, 146: 836-838. PMID: 15973328, DOI: 10.1016/j.jpeds.2005.02.025.Peer-Reviewed Original Research
2004
Comparison of Binax NOW and Directigen for rapid detection of influenza A and B
Landry ML, Cohen S, Ferguson D. Comparison of Binax NOW and Directigen for rapid detection of influenza A and B. Journal Of Clinical Virology 2004, 31: 113-115. PMID: 15364266, DOI: 10.1016/j.jcv.2004.04.005.Peer-Reviewed Original Research
2003
Rapid Enterovirus RNA Detection in Clinical Specimens by Using Nucleic Acid Sequence-Based Amplification
Landry ML, Garner R, Ferguson D. Rapid Enterovirus RNA Detection in Clinical Specimens by Using Nucleic Acid Sequence-Based Amplification. Journal Of Clinical Microbiology 2003, 41: 346-350. PMID: 12517871, PMCID: PMC149595, DOI: 10.1128/jcm.41.1.346-350.2003.Peer-Reviewed Original ResearchConceptsNucleic acid sequence-based amplificationPrimary rhesus monkey kidneyRNA detectionNucliSens Basic KitRhesus monkey kidneyGreen monkey kidney cellsBuffalo green monkey kidney cellsMonkey kidney cellsVirus isolationClinical specimensEnterovirus detectionMonkey kidneyBasic KitMRC-5Kidney cellsCell culturesEV isolationRhabdomyosarcomaKidney
2000
Impact of Sample Type on Rapid Detection of Influenza Virus A by Cytospin-Enhanced Immunofluorescence and Membrane Enzyme-Linked Immunosorbent Assay
Landry M, Cohen S, Ferguson D. Impact of Sample Type on Rapid Detection of Influenza Virus A by Cytospin-Enhanced Immunofluorescence and Membrane Enzyme-Linked Immunosorbent Assay. Journal Of Clinical Microbiology 2000, 38: 429-430. PMID: 10618134, PMCID: PMC88742, DOI: 10.1128/jcm.38.1.429-430.2000.Peer-Reviewed Original Research
1996
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
Einarsson O, Geba G, Zhu Z, Landry M, Elias J. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. Journal Of Clinical Investigation 1996, 97: 915-924. PMID: 8613544, PMCID: PMC507136, DOI: 10.1172/jci118514.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionParainfluenza virus type 3Airway hyperresponsivenessIL-11Viral upper respiratory tract infectionUpper respiratory tract infectionBALB/c miceSimplex virus type 2Viral-induced asthmaViral respiratory infectionsRespiratory tract infectionsNonspecific airway hyperresponsivenessVirus type 2Virus type 3Clinical bronchospasmAirway dysfunctionAirway physiologyTract infectionsRespiratory infectionsRespiratory virusesSyncytial virusC miceNasal aspiratesViral infection
1995
Asthma-Associated Viruses Specifically Induce Lung Stromal Cells to Produce Interleukin-11, a Mediator of Airways Hyperreactivity
Einarsson O, Geba G, Panuska J, Zhu Z, Landry M, Elias J. Asthma-Associated Viruses Specifically Induce Lung Stromal Cells to Produce Interleukin-11, a Mediator of Airways Hyperreactivity. CHEST Journal 1995, 107: 132s-133s. PMID: 7874994, DOI: 10.1378/chest.107.3_supplement.132s.Peer-Reviewed Original Research