2021
Outbreak of Acute Respiratory Illness Associated With Human Adenovirus Type 4 at the United States Coast Guard Academy, 2019
Chu VT, Simon E, Lu X, Rockwell P, Abedi GR, Gardner C, Kujawski SA, Schneider E, Gentile M, Ramsey LA, Liu R, Jones S, Janik C, Siniscalchi A, Landry ML, Christopher J, Lindstrom S, Steiner S, Thomas D, Gerber SI, Biggs HM. Outbreak of Acute Respiratory Illness Associated With Human Adenovirus Type 4 at the United States Coast Guard Academy, 2019. The Journal Of Infectious Diseases 2021, 225: 55-64. PMID: 34139752, DOI: 10.1093/infdis/jiab322.Peer-Reviewed Original ResearchConceptsMedical recordsRespiratory outbreaksPolymerase chain reaction testingReal-time polymerase chain reaction testingNew-onset coughPositive patient samplesAdenovirus type 4Cadet trainingRoutine vaccinationSore throatAdenovirus vaccineIllness AssociatedHuman adenovirus type 4Respiratory specimensUnderlying conditionDuty restrictionsReaction testingPatient samplesType 4Whole-genome sequencingSubstantial numberEnvironmental specimensHAdVOutbreakUS Coast Guard Academy
2020
Clinical impact of rapid influenza PCR in the adult emergency department on patient management, ED length of stay, and nosocomial infection rate
Peaper DR, Branson B, Parwani V, Ulrich A, Shapiro MJ, Clemons C, Campbell M, Owen M, Martinello RA, Landry ML. Clinical impact of rapid influenza PCR in the adult emergency department on patient management, ED length of stay, and nosocomial infection rate. Influenza And Other Respiratory Viruses 2020, 15: 254-261. PMID: 32851793, PMCID: PMC7902247, DOI: 10.1111/irv.12800.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross InfectionEmergency Service, HospitalHumansInfluenza, HumanLength of StayPolymerase Chain ReactionConceptsEmergency departmentInfluenza PCRPatient managementClinical redesignED lengthInfluenza seasonED workflowPCR testingBed transfersAnti-influenza medicationsDiverse emergency departmentsHospital-acquired influenzaInfluenza-positive patientsHA influenzaNosocomial infection ratesDiagnosis of influenzaAdult emergency departmentAnti-viral therapyCommon presenting concernPost-intervention periodPre-post studyED LOSED patientsSignificant morbidityTherapeutic guidelines
2014
Rapid Diagnosis of Influenza State of the Art
Peaper DR, Landry ML. Rapid Diagnosis of Influenza State of the Art. Clinics In Laboratory Medicine 2014, 34: 365-385. PMID: 24856533, PMCID: PMC7172071, DOI: 10.1016/j.cll.2014.02.009.Peer-Reviewed Original ResearchComparison of Simplexa Flu A/B & RSV PCR with Cytospin-Immunofluorescence and Laboratory-Developed TaqMan PCR in Predominantly Adult Hospitalized Patients
Landry ML, Ferguson D. Comparison of Simplexa Flu A/B & RSV PCR with Cytospin-Immunofluorescence and Laboratory-Developed TaqMan PCR in Predominantly Adult Hospitalized Patients. Journal Of Clinical Microbiology 2014, 52: 3057-3059. PMID: 24850350, PMCID: PMC4136128, DOI: 10.1128/jcm.00738-14.Peer-Reviewed Original Research
2013
Comparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens
Gitman MR, Ferguson D, Landry ML. Comparison of Simplexa HSV 1 & 2 PCR with Culture, Immunofluorescence, and Laboratory-Developed TaqMan PCR for Detection of Herpes Simplex Virus in Swab Specimens. Journal Of Clinical Microbiology 2013, 51: 3765-3769. PMID: 24006008, PMCID: PMC3889765, DOI: 10.1128/jcm.01413-13.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overChildChild, PreschoolClinical Laboratory TechniquesCosts and Cost AnalysisFemaleFluorescent Antibody TechniqueHerpes SimplexHumansInfantInfant, NewbornMaleMiddle AgedPolymerase Chain ReactionSensitivity and SpecificitySimplexvirusTime FactorsVirus CultivationYoung AdultHepatitis E virus infection in a liver transplant recipient: delayed diagnosis due to variable performance of serologic assays
Yoo N, Bernstein J, Caldwell C, Dong C, Drobeniuc J, Kamili S, Landry ML. Hepatitis E virus infection in a liver transplant recipient: delayed diagnosis due to variable performance of serologic assays. Transplant Infectious Disease 2013, 15: e166-e168. PMID: 23701647, DOI: 10.1111/tid.12096.Peer-Reviewed Original Research
2009
Comparison of BD GeneOhm Cdiff Real-Time PCR Assay with a Two-Step Algorithm and a Toxin A/B Enzyme-Linked Immunosorbent Assay for Diagnosis of Toxigenic Clostridium difficile Infection
Kvach EJ, Ferguson D, Riska PF, Landry ML. Comparison of BD GeneOhm Cdiff Real-Time PCR Assay with a Two-Step Algorithm and a Toxin A/B Enzyme-Linked Immunosorbent Assay for Diagnosis of Toxigenic Clostridium difficile Infection. Journal Of Clinical Microbiology 2009, 48: 109-114. PMID: 19864479, PMCID: PMC2812270, DOI: 10.1128/jcm.01630-09.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, BacterialBacterial ProteinsBacterial ToxinsBacteriological TechniquesClinical Laboratory TechniquesClostridioides difficileEnterocolitis, PseudomembranousEnterotoxinsEnzyme-Linked Immunosorbent AssayGlutamate DehydrogenaseHumansNeutralization TestsPolymerase Chain ReactionReagent Kits, DiagnosticSensitivity and SpecificityPolymerase chain reaction and the diagnosis of viral gastrointestinal disease due to cytomegalovirus, herpes simplex virus and adenovirus
Landry ML, Ferguson D. Polymerase chain reaction and the diagnosis of viral gastrointestinal disease due to cytomegalovirus, herpes simplex virus and adenovirus. Journal Of Clinical Virology 2009, 45: 83-84. PMID: 19324590, DOI: 10.1016/j.jcv.2009.02.007.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridae InfectionsCytomegalovirus InfectionsGastrointestinal DiseasesHerpes SimplexHumansPolymerase Chain ReactionRetrospective Studies
2008
False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testing
Landry ML, Eid T, Bannykh S, Major E. False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testing. Journal Of Clinical Virology 2008, 43: 247-249. PMID: 18701345, PMCID: PMC2683978, DOI: 10.1016/j.jcv.2008.07.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultDNA, ViralFalse Negative ReactionsFemaleHumansJC VirusJob SyndromeLeukoencephalopathy, Progressive MultifocalPolymerase Chain ReactionConceptsProgressive multifocal leukoencephalopathyPolymerase chain reactionHerpes simplex virus polymerase chain reactionSpinal fluidCSF polymerase chain reactionNegative polymerase chain reactionFatal neurologic illnessesJC virus DNAFalse-negative polymerase chain reactionHigher positive resultsMultifocal leukoencephalopathyBrain biopsyNeurologic illnessDNA polymerase chain reactionNeurologic diseaseBlinded studyPCR testingDiagnostic testingVirus DNAReference laboratoryYoung mothersChain reactionNegative resultsDifferent virusesPositive resultsProspective Study of Human Metapneumovirus Detection in Clinical Samples by Use of Light Diagnostics Direct Immunofluorescence Reagent and Real-Time PCR
Landry ML, Cohen S, Ferguson D. Prospective Study of Human Metapneumovirus Detection in Clinical Samples by Use of Light Diagnostics Direct Immunofluorescence Reagent and Real-Time PCR. Journal Of Clinical Microbiology 2008, 46: 1098-1100. PMID: 18184854, PMCID: PMC2268359, DOI: 10.1128/jcm.01926-07.Peer-Reviewed Original Research
2005
Evidence of a Novel Human Coronavirus That Is Associated with Respiratory Tract Disease in Infants and Young Children
Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Evidence of a Novel Human Coronavirus That Is Associated with Respiratory Tract Disease in Infants and Young Children. The Journal Of Infectious Diseases 2005, 191: 492-498. PMID: 15655770, PMCID: PMC7199485, DOI: 10.1086/428138.Peer-Reviewed Original ResearchConceptsRespiratory tract diseaseTract diseaseNovel human coronavirusHuman coronavirusesYoung childrenNew Haven coronavirusAbnormal breath soundsClinical featuresSymptomatic childrenPolymerase chain reactionRespiratory specimensRespiratory tractCommon findingBreath soundsAnimal CoVsHCoVsNew HavenDiseaseInfantsEtiological agentSubstantial proportionChain reactionChildrenSignificant proportionInfection
2003
Comparison of the NucliSens Basic Kit (Nucleic Acid Sequence-Based Amplification) and the Argene Biosoft Enterovirus Consensus Reverse Transcription-PCR Assays for Rapid Detection of Enterovirus RNA in Clinical Specimens
Landry ML, Garner R, Ferguson D. Comparison of the NucliSens Basic Kit (Nucleic Acid Sequence-Based Amplification) and the Argene Biosoft Enterovirus Consensus Reverse Transcription-PCR Assays for Rapid Detection of Enterovirus RNA in Clinical Specimens. Journal Of Clinical Microbiology 2003, 41: 5006-5010. PMID: 14605131, PMCID: PMC262477, DOI: 10.1128/jcm.41.11.5006-5010.2003.Peer-Reviewed Original ResearchConceptsNucleic acid sequence-based amplificationNucliSens Basic KitRT-PCREnterovirus RNABasic KitEnterovirus-positive samplesReverse transcription-PCR assayTranscription-PCR assayNasopharyngeal samplesRT-PCR kitVirus isolationClinical specimensTranscription-PCRPositive samplesComparable sensitivityKitMolecular methodsEnterovirusesComparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus
Habib-Bein NF, Beckwith WH, Mayo D, Landry ML. Comparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus. Journal Of Clinical Microbiology 2003, 41: 3597-3601. PMID: 12904361, PMCID: PMC179819, DOI: 10.1128/jcm.41.8.3597-3601.2003.Peer-Reviewed Original ResearchConceptsVirus-positive specimensDirect immunofluorescence antibody stainingPublic health laboratoriesHealth laboratoriesRT-PCRMedical CenterRapid diagnosisYale-New Haven HospitalReal-time RT-PCRResults of cultureRhesus monkey kidney cell culturesImmunofluorescence antibody stainingReal-time reverse transcriptionInfluenza A virusesMonkey kidney cell culturesConventional RT-PCR analysisReal-time RT-PCR systemRespiratory specimensInfluenza APatient managementDirect immunofluorescenceCell culturesKidney cell culturesRapid turnaround timeA virus
1997
Use of a single swab in multi-microbe or flex trans transport medium for detection of Chlamydia trachomatis by Roche Amplicor PCR and culture in specimens from two different patient populations
Fong CK, Falcone J, Landry ML. Use of a single swab in multi-microbe or flex trans transport medium for detection of Chlamydia trachomatis by Roche Amplicor PCR and culture in specimens from two different patient populations. Journal Of Clinical Microbiology 1997, 35: 2427-2429. PMID: 9276433, PMCID: PMC229985, DOI: 10.1128/jcm.35.9.2427-2429.1997.Peer-Reviewed Original Research