2008
Gastric Mucosal Defense and Cytoprotection: Bench to Bedside
Laine L, Takeuchi K, Tarnawski A. Gastric Mucosal Defense and Cytoprotection: Bench to Bedside. Gastroenterology 2008, 135: 41-60. PMID: 18549814, DOI: 10.1053/j.gastro.2008.05.030.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStress-related mucosal diseaseProton pump inhibitorsMucosal defenseGastric mucosal defenseMucosal injuryNoxious factorsNonsteroidal anti-inflammatory drugsCOX-2 selective inhibitorsGeneration of PGsImportant clinical sequelaeUpper gastrointestinal complicationsHigh-risk patientsModern intensive careAbsolute risk reductionInhibition of cyclooxygenaseAnti-inflammatory drugsContinuous blood flowGastrointestinal complicationsClinical sequelaePharmacologic therapyAntisecretory drugsSignificant bleedingAnnual incidenceIntensive careSensory innervation
1999
Fingerstick Helicobacter pylori antibody test: better than laboratory serological testing?
Faigel D, Vartan G, Knigge K, Laine L, Fennerty M, Margaret N, Marquis S. Fingerstick Helicobacter pylori antibody test: better than laboratory serological testing? The American Journal Of Gastroenterology 1999, 94: ajg1999810. PMID: 10606304, DOI: 10.1111/j.1572-0241.1999.01510.x.Peer-Reviewed Original Research
1996
Nonsteroidal Anti-Inflammatory Drug Gastropathy
Laine L. Nonsteroidal Anti-Inflammatory Drug Gastropathy. Gastrointestinal Endoscopy Clinics Of North America 1996, 6: 489-504. PMID: 8803564, DOI: 10.1016/s1052-5157(18)30351-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastrointestinal complicationsSubepithelial hemorrhageNonsteroidal anti-inflammatory drug gastropathyDevelopment of NSAIDUpper abdominal symptomsGastric outlet obstructionHalf of patientsPost-treatment biopsiesH. pylori infectionReactive gastritisAbdominal symptomsMajor bleedingMinor bleedingNSAID useUlcer complicationsGastrointestinal bleedingNSAID ingestionNSAID gastropathyOutlet obstructionDuodenal ulcerGastric erosionsHistologic gastritisGastric lesionsGastric ulcerPeptic ulcer
1995
Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers
Laine L, Cohen H, Sloane R, Marin-Sorensen M, Weinstein W. Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers. Gastrointestinal Endoscopy 1995, 42: 420-423. PMID: 8566631, DOI: 10.1016/s0016-5107(95)70043-9.Peer-Reviewed Original ResearchConceptsAntral nodularityPositive predictive valueH. pyloriPredictive valueArea gastricaeEndoscopic findingsEndoscopic featuresInterobserver agreementDiagnostic valueH. pylori gastritisSpecific endoscopic featuresGastric bodyHistologic gastritisPylori gastritisBiopsy specimensHealthy subjectsGastritisNormal volunteersHelicobacter pyloriFull endoscopyPyloriNodularityReproducible findingsErythema
1989
Campylobacter pylori in alcoholic hemorrhagic “gastritis”
Laine L, Marin-Sorensen M, Weinstein W. Campylobacter pylori in alcoholic hemorrhagic “gastritis”. Digestive Diseases And Sciences 1989, 34: 677-680. PMID: 2785447, DOI: 10.1007/bf01540337.Peer-Reviewed Original ResearchConceptsSubepithelial hemorrhageCampylobacter pyloriInflammatory cell scoresInflammatory cell densityMucosal hemorrhageEdema scoreAlcoholic patientsHistologic abnormalitiesMononuclear cellsBiopsy specimensEpithelial abnormalitiesHemorrhagic lesionsNeutrophil scoreHemorrhage scoreHistologic scoringHemorrhageMucosaBiopsyBiopsy slidesMean scoreScoresPresence of CPPyloriAbnormalitiesCell density
1988
Histology of alcoholic hemorrhagic “gastritis”: A prospective evaluation
Laine L, Weinstein W. Histology of alcoholic hemorrhagic “gastritis”: A prospective evaluation. Gastroenterology 1988, 94: 1254-1262. PMID: 3258836, DOI: 10.1016/0016-5085(88)90661-0.Peer-Reviewed Original ResearchConceptsSubepithelial hemorrhageAlcoholic patientsHemorrhagic gastritisBiopsy specimensProminent inflammatory cell infiltrationFoveolar regionInflammatory cell infiltrateInflammatory cell infiltrationGastrointestinal bleedingUpper endoscopyCell infiltrateMucosal edemaProspective evaluationAdjacent mucosaBarrett's esophagusCell infiltrationGastric biopsiesHemorrhagic lesionsTarget lesionsHistologic natureHemorrhage scoreHistologic scoringBiopsy siteHemorrhagePatientsSubepithelial hemorrhages and erosions of human stomach
Laine L, Weinstein W. Subepithelial hemorrhages and erosions of human stomach. Digestive Diseases And Sciences 1988, 33: 490-503. PMID: 3280275, DOI: 10.1007/bf01536037.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements