1994
The natural history of esophageal candidiasis after successful treatment in patients with AIDS
Laine L. The natural history of esophageal candidiasis after successful treatment in patients with AIDS. Gastroenterology 1994, 107: 744-746. PMID: 8076760, DOI: 10.1016/0016-5085(94)90122-8.Peer-Reviewed Original ResearchConceptsEsophageal candidiasisOral thrushImmunodeficiency syndromeAntifungal therapySuccessful treatmentNatural historyMonthly clinical assessmentsRecurrent esophageal candidiasisPosttreatment endoscopySymptomatic recurrenceEndoscopic resolutionEsophageal symptomsMost patientsOral therapyClinical resolutionRecurrent episodesEntry criteriaClinical assessmentBACKGROUND/Prior episodesPatientsCandidiasisSubsequent episodesTherapySubsequent course
1992
Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. A randomized trial.
Laine L, Dretler RH, Conteas CN, Tuazon C, Koster FM, Sattler F, Squires K, Islam MZ. Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. A randomized trial. Annals Of Internal Medicine 1992, 117: 655-60. PMID: 1308663, DOI: 10.7326/0003-4819-117-8-655.Peer-Reviewed Original ResearchConceptsCandida esophagitisCounty hospital settingFluconazole-treated patientsDouble-blind trialResolution of symptomsOral antifungal agentsEnd of therapyEndoscopic responseRetrosternal painStudy medicationClinical cureEsophageal symptomsSymptomatic improvementTreat analysisImmunodeficiency syndromeEndoscopic cureAntifungal therapyEsophageal brushingsHospital settingPatientsSide effectsWeek 1U.S. CentersEsophagitisTherapy
1991
The causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients.
Bonacini M, Young T, Laine L. The causes of esophageal symptoms in human immunodeficiency virus infection. A prospective study of 110 patients. JAMA Internal Medicine 1991, 151: 1567-72. PMID: 1651690, DOI: 10.1001/archinte.151.8.1567.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBlind brushingHerpes simplex virusViral cultureHistologic examinationVirus infectionCandida esophagitisEsophageal symptomsSimplex virusViral infectionProspective clinical case studyUrban county hospitalPositive predictive valueDiagnosis of esophagitisEsophageal infectionsInfectious esophagitisViral esophagitisConsecutive patientsOral thrushOrogastric tubeEsophageal biopsiesProspective studyVirologic testingBiopsy specimens