2022
Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients
Laursen S, Stanley A, Laine L, de Muckadell O. Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients. Scandinavian Journal Of Gastroenterology 2022, 57: 1423-1429. PMID: 35853234, DOI: 10.1080/00365521.2022.2098050.Peer-Reviewed Original ResearchConceptsPeptic ulcer bleedingNationwide cohort studyUlcer bleedingHemodynamic instabilityCohort studyDuodenal ulcerHigh-risk endoscopic stigmataNon-ulcer lesionsHigh-risk stigmataLogistic regression analysisEndoscopic stigmataPersistent bleedingEndoscopic therapyFrequent complicationConsecutive patientsSuch patientsPrognostic consequencesHigh riskPatientsInterventional radiologyBleedingTwo-fold increaseMortalityUlcersStrongest predictorInternational multicenter study comparing demographics, therapy and outcomes in bleeding from Mallory Weiss tears and peptic ulcers
Tham JE, Lynch L, Laursen SB, Laine L, Dalton HR, Ngu J, Redondo-Cerezo E, Schultz M, Murray I, Michell N, Morris AJ, Nielsen MM, Stanley AJ. International multicenter study comparing demographics, therapy and outcomes in bleeding from Mallory Weiss tears and peptic ulcers. Endoscopy International Open 2022, 10: e653-e658. PMID: 35571482, PMCID: PMC9106442, DOI: 10.1055/a-1784-0655.Peer-Reviewed Original ResearchMallory-Weiss tearUpper gastrointestinal bleedingPeptic ulcer bleedingEndoscopic therapyEndoscopic stigmataEpinephrine injectionAcute upper gastrointestinal bleedingInternational multicenter studyPUB patientsGastrointestinal bleedingUlcer bleedingUncommon causeMulticenter studyPeptic ulcerPoor outcomeScope clipInternational cohortClean baseLower riskBaseline parametersPatientsTherapyBleedingCommon modalityMortality
2021
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding
Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. The American Journal Of Gastroenterology 2021, 116: 899-917. PMID: 33929377, DOI: 10.14309/ajg.0000000000001245.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUpper gastrointestinal bleedingEndoscopic therapyGastrointestinal bleedingHigh-dose proton pump inhibitor therapyOvert upper gastrointestinal bleedingOral proton pump inhibitorsProton pump inhibitor therapyRed blood cell transfusionAbsolute ethanol injectionWeeks of therapyBlood cell transfusionLow-quality evidenceLow-risk patientsManagement of patientsProton pump inhibitorsArgon plasma coagulationActive spurtingErythromycin infusionTC-325Cell transfusionRecurrent bleedingRecurrent ulcersUlcer bleedingEndoscopic hemostasisGRADE approach
2019
Management of acute upper gastrointestinal bleeding
Stanley AJ, Laine L. Management of acute upper gastrointestinal bleeding. The BMJ 2019, 364: l536. PMID: 30910853, DOI: 10.1136/bmj.l536.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnti-Bacterial AgentsBlood TransfusionDisease ManagementEndoscopy, GastrointestinalEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansLiver CirrhosisPortasystemic Shunt, Transjugular IntrahepaticPractice Guidelines as TopicProton Pump InhibitorsResuscitationSeverity of Illness IndexConceptsUpper gastrointestinal bleedingProton pump inhibitorsVariceal bleedingUlcer bleedingGastrointestinal bleedingEndoscopic therapyVasoactive drugsPump inhibitorsHigh-dose proton pump inhibitorsAcute upper gastrointestinal bleedingDose proton pump inhibitorsTransjugular intrahepatic portosystemic shuntNon-variceal bleedingRecurrent ulcer bleedingRecurrent variceal bleedingRed cell transfusionCommon medical emergencyIntrahepatic portosystemic shuntEarly endoscopyCell transfusionHemodynamic instabilityHemoglobin thresholdEndoscopic treatmentIntravenous fluidsPortosystemic shunt
2012
Trends for Incidence of Hospitalization and Death Due to GI Complications in the United States From 2001 to 2009
Laine L, Yang H, Chang SC, Datto C. Trends for Incidence of Hospitalization and Death Due to GI Complications in the United States From 2001 to 2009. The American Journal Of Gastroenterology 2012, 107: 1190. PMID: 22688850, DOI: 10.1038/ajg.2012.168.Peer-Reviewed Original ResearchConceptsCase fatalityGI complicationsLGI bleedingUGI bleedingUGI complicationsGastrointestinal complicationsLower gastrointestinal complicationsColonic diverticular bleedingIncidence of hospitalizationNational inpatient databasePeptic ulcer bleedingPrimary discharge diagnosisSex-adjusted incidenceUpper gastrointestinal complicationsCase fatality rateDiverticular bleedingUGI perforationsGI bleedingUlcer bleedingDischarge diagnosisInpatient DatabaseBleedingComplicationsFatality rateHospitalizationManagement of Patients With Ulcer Bleeding
Laine L, Jensen DM. Management of Patients With Ulcer Bleeding. The American Journal Of Gastroenterology 2012, 107: 345. PMID: 22310222, DOI: 10.1038/ajg.2011.480.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBlood TransfusionClinical Trials as TopicEndoscopy, GastrointestinalErythromycinEvidence-Based MedicineFluid TherapyGastric LavageHemostasis, EndoscopicHumansMeta-Analysis as TopicPatient SelectionPeptic Ulcer HemorrhagePrognosisProton Pump InhibitorsResuscitationRetreatmentRisk AssessmentSecondary PreventionConceptsNonsteroidal anti-inflammatory drugsAnti-ulcer therapyEndoscopic therapyHemodynamic statusCOX-2-selective nonsteroidal anti-inflammatory drugsNon-bleeding visible vesselOvert upper gastrointestinal bleedingDirect further managementSecond endoscopic treatmentStep-wise managementUpper gastrointestinal bleedingManagement of patientsProton pump inhibitorsAnti-inflammatory drugsIdiopathic ulcersPPI therapyActive bleedingGastrointestinal bleedingRecurrent bleedingUlcer bleedingEndoscopic featuresFirst endoscopyUpper endoscopyAdherent clotEndoscopic treatment
2003
Celecoxib was as effective as diclofenac plus omeprazole in reducing recurrent ulcer bleeding in arthritis.
Laine L. Celecoxib was as effective as diclofenac plus omeprazole in reducing recurrent ulcer bleeding in arthritis. Annals Of Internal Medicine 2003, 139: 12. PMID: 12841716, DOI: 10.7326/acpjc-2003-139-1-012.Commentaries, Editorials and LettersRecurrent ulcer bleedingUlcer bleeding