2020
Physicians' Perceptions of Proton Pump Inhibitor Risks and Recommendations to Discontinue: A National Survey.
Kurlander JE, Rubenstein JH, Richardson CR, Krein SL, De Vries R, Zikmund-Fisher BJ, Yang YX, Laine L, Weissman A, Saini SD. Physicians' Perceptions of Proton Pump Inhibitor Risks and Recommendations to Discontinue: A National Survey. The American Journal Of Gastroenterology 2020, 115: 689-696. PMID: 32091419, PMCID: PMC7196016, DOI: 10.14309/ajg.0000000000000558.Peer-Reviewed Original ResearchConceptsProton pump inhibitorsPPI adverse effectsAdverse effectsHigh riskLong-term PPI useGastroesophageal reflux diseaseMultiple adverse effectsPPI useReflux diseasePPI discontinuationInhibitor riskMost internistsPump inhibitorsPhysicians' perceptionsInternists' perceptionsSignificant associationGeneral medicineDiscontinuationLogistic regressionClinical usePatientsFuture interventionsIndividual riskPreventionUGIB
2019
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn
Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. New England Journal Of Medicine 2019, 381: 1513-1523. PMID: 31618539, DOI: 10.1056/nejmoa1811424.Peer-Reviewed Original ResearchConceptsPPI-refractory heartburnActive medical treatmentMedical treatmentTreatment successGastroenterology clinicSurgical treatmentProton pump inhibitor treatmentMultichannel intraluminal impedance-pH monitoringMedical groupGastroesophageal reflux diseaseFrequent clinical problemMinority of patientsHealth Related QualityImpedance-pH monitoringMultiple potential causesFunctional heartburnRefractory heartburnVisceral hypersensitivityAntireflux surgeryGastroesophageal refluxReflux diseaseUnderwent endoscopyEsophageal manometryPrimary outcomeEsophageal biopsies
2018
Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease
Parikh ND, Viana AV, Shah S, Laine L. Image-enhanced endoscopy is specific for the diagnosis of non-erosive gastroesophageal reflux disease. Scandinavian Journal Of Gastroenterology 2018, 53: 260-264. PMID: 29368532, PMCID: PMC6080852, DOI: 10.1080/00365521.2018.1430847.Peer-Reviewed Original ResearchConceptsNon-erosive gastroesophageal reflux diseaseGastroesophageal reflux diseaseImage-enhanced endoscopyNarrow-band imagingReflux diseaseEndoscopic findingsSquamocolumnar junctionUpper endoscopyPatient acceptanceEndoscopyBand imagingI-scanVascularityAdditional studiesPit patternHeartburnPatientsDiseaseDiagnosisImpedance monitoringRRSpecificityFindingsControlCases
2009
Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective
Sharma P, Chey W, Hunt R, Laine L, Malfertheiner P, Wani S. Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective. Diseases Of The Esophagus 2009, 22: 461-466. PMID: 19191851, DOI: 10.1111/j.1442-2050.2008.00934.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastroesophageal reflux diseaseGERD-like symptomsSuppressive therapyReflux diseaseAcid suppressive therapyErosive reflux diseaseProspective multicenter studyCommon chronic disorderPrimary care physiciansPrimary care settingSymptom-based classificationSymptom-based diagnosisHuge economic burdenInternational Consensus GroupErosive esophagitisGERD patientsTroublesome symptomsEmpiric trialPartial responseComplete responseCare physiciansImpaired qualityMulticenter studyBarrett's esophagusChronic disorders
2003
Oro-pharyngeal biopsy: a new technique for gastroeternologists to evaluate patients with gastroesophageal reflux disease (GERD)
Yang R, Zinn S, Maceri D, Laine L. Oro-pharyngeal biopsy: a new technique for gastroeternologists to evaluate patients with gastroesophageal reflux disease (GERD). The American Journal Of Gastroenterology 2003, 98: s293. DOI: 10.1111/j.1572-0241.2003.08620.x.Peer-Reviewed Original Research
2002
Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies
Sugg J, Laine L. Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies. The American Journal Of Gastroenterology 2002, 97: 2992. PMID: 12492181, DOI: 10.1111/j.1572-0241.2002.07116.x.Peer-Reviewed Original ResearchConceptsPersistent H. pyloriErosive esophagitisGERD symptomsH. pyloriSymptomatic GERDPersistent infectionDouble-blind prospective studyDouble-blind prospective trialGastroesophageal reflux disease symptomsCompletion of therapyDuodenal ulcer diseaseGastroesophageal reflux diseaseHelicobacter pylori eradicationHelicobacter pylori therapyWorsening of symptomsEnd of therapyRapid urease testBlind prospective studyPylori eradicationPylori therapyReflux diseaseRegurgitation scoreProspective trialDuodenal ulcerUlcer disease