2021
Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage
Geer JH, Falcone GJ, Vanent KN, Leasure AC, Woo D, Molano JR, Sansing LH, Langefeld CD, Pisani MA, Yaggi HK, Sheth KN. Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage. Stroke 2021, 52: 1835-1838. PMID: 33827242, PMCID: PMC8085039, DOI: 10.1161/strokeaha.120.033342.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaRisk factorsBerlin questionnaireIntracerebral hemorrhageSleep apneaEthnic/Racial VariationsHigher body mass indexMultivariable logistic regression modelBody mass indexIntracerebral hemorrhage riskCase-control studyExposure of patientsLogistic regression analysisLogistic regression modelsOSA statusHemorrhage riskMass indexHeart diseaseNontraumatic ICHRacial variationApneaHemorrhageRegression analysisICHRegression models
2020
Aging exacerbates neutrophil pathogenicity in ischemic stroke
Roy-O'Reilly MA, Ahnstedt H, Spychala MS, Munshi Y, Aronowski J, Sansing LH, McCullough LD. Aging exacerbates neutrophil pathogenicity in ischemic stroke. Aging 2020, 12: 436-461. PMID: 31927534, PMCID: PMC6977697, DOI: 10.18632/aging.102632.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsIschemic strokeNeutrophil-activating cytokineStroke patientsNeutrophil functionNeutrophil reactive oxygen speciesPoor post-stroke outcomesDepletion of neutrophilsPro-inflammatory functionsStrong risk factorExperimental mouse modelPost-stroke outcomesHigher stroke mortalityStroke outcomePoor outcomeFunctional outcomeStroke mortalityLong-term benefitsRisk factorsSpecific monoclonal antibodiesNeutrophil trafficTissue injuryYoung miceAged subjectsMouse model
2009
Who will participate in acute stroke trials?
Kasner SE, Del Giudice A, Rosenberg S, Sheen M, Luciano JM, Cucchiara BL, Messé S, Sansing LH, Baren JM. Who will participate in acute stroke trials? Neurology 2009, 72: 1682-1688. PMID: 19433742, PMCID: PMC2683644, DOI: 10.1212/wnl.0b013e3181a55fbe.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAttitude to HealthBiomedical ResearchCaregiversClinical Trials as TopicCultureData CollectionFemaleHumansInformed ConsentMaleMental CompetencyMiddle AgedPatient CompliancePatient Education as TopicPhysician-Patient RelationsProspective StudiesRisk AssessmentRisk-TakingStrokeConceptsAcute treatment trialsAcute strokeTreatment trialsClinical trialsAcute stroke treatment trialsAcute stroke clinical trialsMean age 63Stroke treatment trialsVascular risk factorsMinority of patientsAcute stroke trialsStroke clinical trialsNovel therapeutic agentsStroke severityClinical factorsPrimary outcomeStroke trialsAcute trialProspective surveyTrial interventionRisk factorsStroke typeHigh incidenceAge 63Patients