Targeted Therapy in Breast Cancer The HER-2/neu Gene and Protein
Ross JS, Fletcher JA, Bloom KJ, Linette GP, Stec J, Symmans WF, Pusztai L, Hortobagyi GN. Targeted Therapy in Breast Cancer The HER-2/neu Gene and Protein. Molecular & Cellular Proteomics 2004, 3: 379-398. PMID: 14762215, DOI: 10.1074/mcp.r400001-mcp200.Peer-Reviewed Original ResearchConceptsBreast cancerNeu statusHormonal therapyAdvanced metastatic breast cancerHER-2/neu oncogeneHER-2/neu statusNew hormonal therapiesSerum-based testingMale breast cancerMetastatic breast cancerBreast cancer specimensClinical breast cancer specimensNeu gene amplificationEpidermal growth factor receptorTransmembrane tyrosine kinase receptorPrediction of responseGrowth factor receptorTyrosine kinase receptorsTrastuzumab therapyDuctal carcinomaNeu overexpressionHER-2Targeted therapyTumor cytosolsDisease outcome