2024
Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study.
Wojeck B, Inzucchi S, Qin L, Yaggi H. Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study. Journal Of Clinical Sleep Medicine 2023, 19: 703-710. PMID: 36689314, PMCID: PMC10071389, DOI: 10.5664/jcsm.10414.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexBody mass indexIncident diabetesPolysomnographic predictorsMass indexOxygen saturationMean nocturnal oxygen saturationObstructive sleep apnea (OSA) evaluationObstructive sleep apnea populationEpworth Sleepiness Scale scoreSleep apnea populationGlucose-lowering medicationsNocturnal oxygen saturationSleep-disordered breathingIncidence of diabetesPeriodic limb movementsLaboratory-based polysomnographyCheyne-Stokes respirationSleep apnea severitySleep apnea evaluationIncident prediabetesOxygen desaturationCentral apneaHemoglobin A1cPrimary outcome
2022
0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA)
Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.Peer-Reviewed Original ResearchOutcome expectanciesContinuous positive airway pressureObstructive sleep apneaSub-scale scoresRisk perceptionSelf-efficacy measuresCPAP adherenceIndividual risk perceptionInsomnia Severity Index scoreCPAP therapyEffectiveness of CPAPNon-CPAP therapiesUnstable medical conditionsCo-primary outcomesFirst-line therapyPositive airway pressureApnea-hypopnea indexSeverity Index scoreEpworth Sleepiness ScalePerceptionSex differencesCPAP useOSA severityAirway pressureDaytime symptoms
2021
Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.
Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaPolysomnographic phenotypeIncident T2DMRisk of T2DMPredictive valueSleep apneaBlood glucoseRisk factorsCardiovascular diseaseMild obstructive sleep apneaIncident type 2 diabetesMultivariable-adjusted regression modelsCox proportional hazards regressionNew physician diagnosisT2DM risk predictionIncident cardiovascular diseaseIncident type 2Body mass indexProportional hazards regressionT2DM risk factorsBehavioral risk factorsType 2 diabetesMale veteran populationRisk regression models
2019
0494 Associations of Obstructive Sleep Apnea with Renal Function Decline in a Cohort of Veterans
Liu J, Qin L, McConaughey C, Yaggi H. 0494 Associations of Obstructive Sleep Apnea with Renal Function Decline in a Cohort of Veterans. Sleep 2019, 42: a198-a198. DOI: 10.1093/sleep/zsz067.492.Peer-Reviewed Original ResearchObstructive sleep apneaRenal function declineApnea-hypopnea indexChronic kidney diseaseSevere obstructive sleep apneaDiabetes statusFunction declineSleep apneaSleep medicine clinicHypertension statusAssociation of OSAMild-moderate obstructive sleep apneaSlower renal function declineClinic-based cohortCohort of patientsGlomerular filtration rateCommunity-based cohortCohort of veteransMultivariable regression analysisEnd of observationRenal functionBaseline prevalenceKidney diseaseMedicine clinicFiltration rate
2009
Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes
Botros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes. The American Journal Of Medicine 2009, 122: 1122-1127. PMID: 19958890, PMCID: PMC2799991, DOI: 10.1016/j.amjmed.2009.04.026.Peer-Reviewed Original ResearchConceptsMore severe sleep apneaPositive airway pressure useSevere sleep apneaObstructive sleep apneaRisk of diabetesSleep apneaRisk factorsIncident diabetesMAIN OUTCOMEPositive airway pressure therapyType 2 diabetes mellitusVeterans Affairs Connecticut Healthcare SystemAirway pressure therapyObservational cohort studyApnea-hypopnea indexSleep-disordered breathingBody mass indexCross-sectional studyCohort studyDiagnostic polysomnogramGlucose intoleranceConsecutive patientsDiabetes mellitusMass indexPhysician diagnosisThe effect of gender on the prevalence of hypertension in obstructive sleep apnea
Mohsenin V, Yaggi HK, Shah N, Dziura J. The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Medicine 2009, 10: 759-762. PMID: 19185538, DOI: 10.1016/j.sleep.2008.09.005.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaApnea-hypopnea indexPrevalence of hypertensionSD ageSleep apneaOSA groupContext of OSASeverity of OSAMultiple logistic regression analysisSleep disorder evaluationOdds of hypertensionClinic-based populationSleep apnea severityEffect of genderCross-sectional studyLogistic regression analysisHypertension increasesPrevalent hypertensionSystemic hypertensionObese menHighest quartileApnea severityHypertensionLarge cohortHigh risk
2005
Obstructive Sleep Apnea as a Risk Factor for Stroke and Death
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. New England Journal Of Medicine 2005, 353: 2034-2041. PMID: 16282178, DOI: 10.1056/nejmoa043104.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea-hypopnea indexMean apnea-hypopnea indexRisk of strokeApnea syndromeRisk factorsSleep apneaComposite end pointObservational cohort studyObstructive sleep apneaProportional hazards analysisComparison groupAlcohol consumption statusBody mass indexImportant risk factorCohort studyComposite outcomeConsecutive patientsDiabetes mellitusSmoking statusAtrial fibrillationUnadjusted analysesSyndromePatients