2024
Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participantsSecondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure control
2023
Disability Status and Secondary Prevention Among Survivors of Stroke: A Cross‐Sectional Analysis of the 2011 to 2018 National Health and Nutrition Examination Survey
Zhou T, de Havenon A, Sheth K, Ross J. Disability Status and Secondary Prevention Among Survivors of Stroke: A Cross‐Sectional Analysis of the 2011 to 2018 National Health and Nutrition Examination Survey. Journal Of The American Heart Association 2023, 12: e030869. PMID: 38014672, PMCID: PMC10727323, DOI: 10.1161/jaha.123.030869.Peer-Reviewed Original ResearchAntithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry
Murthy S, Zhang C, Shah S, Schwamm L, Fonarow G, Smith E, Bhatt D, Ziai W, Kamel H, Sheth K. Antithrombotic and Statin Prescription After Intracerebral Hemorrhage in the Get With The Guidelines-Stroke Registry. Stroke 2023, 54: 2972-2980. PMID: 37942641, PMCID: PMC10842167, DOI: 10.1161/strokeaha.123.043194.Peer-Reviewed Original ResearchConceptsIschemic vascular diseaseProportion of patientsGuidelines-Stroke registryLipid-lowering therapyIntracerebral hemorrhageVascular diseaseStatin therapyAnticoagulation therapyCardiovascular eventsAtrial fibrillationFuture major cardiovascular eventsLower admission National InstitutesPrevious lipid-lowering therapyAdmission National InstitutesFavorable discharge outcomeIschemic cardiovascular eventsHealth Stroke ScaleMajor cardiovascular eventsLipid-lowering medicationsCross-sectional studyMultiple logistic regressionLogistic regression analysisAntiplatelet medicationsAntiplatelet therapyStatin medicationRacial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage
Simonetto M, Sheth K, Ziai W, Iadecola C, Zhang C, Murthy S. Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage. Stroke 2023, 54: 2401-2408. PMID: 37462054, PMCID: PMC10529487, DOI: 10.1161/strokeaha.123.043160.Peer-Reviewed Original ResearchMeSH KeywordsAtrial FibrillationCerebral HemorrhageEthnicityHumansIschemic StrokeRetrospective StudiesRisk FactorsStrokeConceptsNon-Hispanic white patientsNon-Hispanic blacksIschemic strokeIntracerebral hemorrhageHispanic patientsWhite patientsAtrial fibrillationICH patientsHigh riskNon-Hispanic black patientsCox proportional hazards modelIncident ischemic strokeRetrospective cohort studyNontraumatic intracerebral hemorrhageValvular heart diseaseTime of dischargeLarge heterogeneous cohortProportional hazards modelNon-Hispanic whitesICH hospitalizationsCardiovascular comorbiditiesMedian followCohort studyVascular comorbiditiesConcomitant diagnosisBaseline Cardiovascular Risk Factor Control in Patients With Type 2 Diabetes and Coronary Disease Versus Stroke: Secondary Analysis of Cardiovascular Outcome Trials
Balasubramanian P, Kernan W, Sheth K, Ofstad A, Rosenstock J, Wanner C, Zinman B, Mattheus M, Marx N, Inzucchi S. Baseline Cardiovascular Risk Factor Control in Patients With Type 2 Diabetes and Coronary Disease Versus Stroke: Secondary Analysis of Cardiovascular Outcome Trials. Stroke 2023, 54: 2013-2021. PMID: 37449424, PMCID: PMC10358436, DOI: 10.1161/strokeaha.122.042053.Peer-Reviewed Original ResearchConceptsCardiovascular risk factor controlRisk factor controlCoronary artery diseaseEMPA-REG OUTCOMECardiovascular outcome trialsType 2 diabetesRisk factorsOutcome trialsBlood pressureOdds ratioAntiplatelet/anticoagulant medicationsAntiplatelet/anticoagulant therapyDiabetes cardiovascular outcome trialsSuboptimal risk factor controlCardiovascular risk factorsRecurrent ischemic eventsDiastolic blood pressureSystolic blood pressureRespective odds ratiosFactor controlCross-sectional analysisLogistic regression modelsMacrovascular complicationsStatin useAnticoagulant medicationHigher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchMeSH KeywordsHemorrhagic StrokeHospitalsHumansPopulation HealthRetrospective StudiesRisk FactorsStrokeConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar associationChange in Smoking Behavior and Outcome After Ischemic Stroke: Post-Hoc Analysis of the SPS3 Trial
Anadani M, Turan T, Yaghi S, Spiotta A, Gory B, Sharma R, Sheth K, de Havenon A. Change in Smoking Behavior and Outcome After Ischemic Stroke: Post-Hoc Analysis of the SPS3 Trial. Stroke 2023, 54: 921-927. PMID: 36876480, PMCID: PMC10050138, DOI: 10.1161/strokeaha.121.038202.Peer-Reviewed Original ResearchMeSH KeywordsHemorrhageHumansIschemic StrokeMyocardial InfarctionRisk FactorsSmokingStrokeTreatment OutcomeConceptsMajor adverse cardiovascular eventsAdverse cardiovascular eventsAcute ischemic strokeIschemic strokeCardiovascular eventsPersistent smokersPersistent smokingSPS3 trialSmoking statusMyocardial infarctionMajor adverse cardiovascular events outcomesCardiovascular event outcomesMajor cardiovascular outcomesSubsequent cardiovascular eventsHistory of hypertensionRisk of strokeEnd of studyPost Hoc AnalysisPrior smokersRandomization armCardiovascular outcomesFormer smokersMonth 3Primary outcomeTotal cohortSpontaneous Intracerebral Hemorrhage. Reply.
Sheth K. Spontaneous Intracerebral Hemorrhage. Reply. New England Journal Of Medicine 2023, 388: 192. PMID: 36630641, DOI: 10.1056/nejmc2215234.Peer-Reviewed Original Research
2021
Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
Denson J, Gillet A, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas I, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer J, Armaignac D, Belden K, Kaufman M, Heavner S, Danesh V, Cheruku S, St. Hill C, Boman K, Deo N, Bansal V, Kumar V, Walkey A, Kashyap R, Mesland J, Henin P, Petre H, Buelens I, Gerard A, Clevenbergh P, Del Granado R, Mercado J, Vega-Terraza E, Iturricha-Caceres M, Garza R, Chu E, Chan V, Gavidia O, Pachon F, Kassas M, Tawheed A, Pineda E, Reyes Guillen G, Soto H, Vallecillo Lizardo A, Segu S, Chakraborty T, Joyce E, Kasumalla P, Vadgaonkar G, Ediga R, Basety S, Dammareddy S, Raju U, Manduva J, Kolakani N, Sripathi S, Chaitanya S, Cherian A, Parameswaran S, Parthiban M, Menu P, Daga M, Agarwal M, Rohtagi I, Papani S, Kamuram M, Agrawal K, Baghel V, Patel K, Mohan S, Jyothisree E, Dalili N, Nafa M, Matsuda W, Suzuki R, Sanui M, Horikita S, Itagaki Y, Kodate A, Takahashi Y, Moriki K, Shiga T, Iwasaki Y, Rodriguez-Gutierrez R, Gonzale J, Salcido-Montenegro A, Camacho-Ortiz A, Hassan-Hanga F, Galadanci H, Gezawa A, Kabir H, Amole T, Haliru D, Ibrahim A, Asghar M, Syed M, Naqvi S, Zabolotskikh I, Musaeva T, Alamoudi R, AlSharif H, Almazwaghi S, Elsakran M, Aid M, Darwich M, Hagag O, Ali S, Rocacorba A, Supena K, Juane E, Medina J, Baduria J, Amer M, Bawazeer M, Dahhan T, Kseibi E, Butt A, Khurshid S, Rabee M, Abujazar M, Alghunaim R, Abualkhair M, AlFirm A, Almazyad M, Alarifi M, Macarambon J, Bukhari A, Albahrani H, Asfina K, Aldossary K, Zoran M, Popadic V, Klasnja S, Bojicic J, Kovacevic B, Predrag S, Stojakov D, Ignjatovic D, Bojicic S, Bobos M, Nenadic I, Zaric M, Djuric M, Djukic V, Teruel S, Martin B, Sili U, Bilgin H, Ay P, Dodd K, Goodmanson N, Hesse K, Bird P, Weinert C, Schoenrade N, Altaher A, Mayar E, Aronson M, Cooper T, Logan M, Miner B, Papo G, Siegal E, Runningen P, Patel L, Melamed R, Tierney D, Raj V, Mazumder N, Hill C, Kirkland L, Schmitz N, Sigman A, Hall J, Raval A, Franks A, Jarvis J, Kharbanda A, Jhajhria S, Fyffe Z, Capizzi S, Alicie B, Green M, Corckarell L, Drennan A, Dubuque K, Fambrough T, Gasaway N, Krantz B, Nebi P, Orga J, Serfass M, Simion A, Warren K, Wheeler C, Woolman C, Christie A, Ashley D, Adiga R, Moyer A, Verghese G, Sikora Newsome A, Forehand C, Bruning R, Jones T, Sabov M, Zaidi F, Tissavirasingham F, Malipeddi D, Mosier J, Lutrick K, Campbell B, Wilson C, Rivers P, Brinks J, Ndiva Mongoh M, Gilson B, Armaignac D, Parris D, Zuniga M, Vargas I, Boronat V, Hutton A, Kaur N, Neupane P, Sadule-Rios N, Rojas L, Neupane A, Rivera P, Valle Carlos C, Vincent G, Amin M, Schelle M, Steadham A, Howard C, McBride C, Abraham J, Garner O, Richards K, Collins K, Antony P, Mathew S, Danesh V, Dubrocq G, Davis A, Hammers M, McGahey I, Farris A, Priest E, Korsmo R, Fares L, Skiles K, Shor S, Burns K, Flores M, Newman L, Wilk D, Ettlinger J, Bomar J, Darji H, Arroliga A, Dowell C, Gonzales G, Flores M, Walkey A, Waikar S, Garcia M, Colona M, Kibbelaar Z, Leong M, Wallman D, Soni K, Maccarone J, Gilman J, Devis Y, Chung J, Paracha M, Lumelsky D, DiLorenzo M, Abdurrahman N, Johnson S, Hersh M, Wachs S, Swigger B, Sattler L, Moulton M, Zammit K, McGrath P, Loeffler W, Chilbert M, Tirupathi R, Tang A, Safi A, Green C, Newell J, Ramani N, Ganti B, Ihle R, Davis E, Martin S, Sayed I, Gist K, Strom L, Chiotos K, Blatz A, Lee G, Burnett R, Sydney G, Traynor D, Surani S, White J, Khan A, Dhahwal R, Cheruku S, Ahmed F, Deonarine C, Jones A, Shaikh M, Preston D, Chin J, Vachharajani V, Duggal A, Rajendram P, Mehkri O, Dugar S, Biehl M, Sacha G, Houltham S, Kind A, Ashok K, Poynter B, Beukemann M, Rice R, Gole S, Shaner V, Conjeevaram A, Ferrari M, Alappan N, Minear S, Hernandez-Montfort J, Nasim S, Sunderkrishnan R, Sahoo D, Milligan P, Gupta S, Koglin J, Gibson R, Johnson L, Preston F, Scott C, Nungester B, Byrne D, Schorr C, Grant K, Doktar K, Porto M, Kaplan O, Siegler J, Schonewald B, Woodford A, Tsai A, Reid S, Bhowmick K, Daneshpooy S, Mowdawalla C, Dave T, Connor Crudeli W, Ferry C, Nguyen L, Modi S, Padala N, Patel P, Lin B, Qiuyun J, Liu F, Kota R, Banerjee A, Daugherty S, Atkinson S, Shrimpton K, Ontai S, Contreras B, Obinwanko U, Amamasi N, Sharafi A, Lee S, Esber Z, Jinjvadia C, Bartz R, Krishnamoorthy V, Kraft B, Pulsipher A, Friedman E, Mehta S, Kaufman M, Lobel G, Gandhi N, Abdelaty A, Shaji E, Lim K, Marte J, Sosa D, Yamane D, Benjenk I, Prasanna N, Perkins N, Roth P, Litwin A, Pariyadath A, Moschella P, Llano T, Waller C, Kallies K, Thorsen J, Fitzsimmons A, Olsen H, Smalls N, Davis S, Jovic V, Masuda M, Hayes A, Nault K, Smith M, Snow W, Liptak R, Durant H, Pendleton V, Nanavati A, Mrozowsk R, Doubleday E, Liu Y, Zavala S, Shim E, Reilkoff R, Heneghan J, Eichen S, Goertzen L, Rajala S, Feussom G, Tang B, Junia C, Lichtenberg R, Sidhu H, Espinoza D, Rodrigues S, Zabala M, Goyes D, Susheela A, Hatharaliyadda B, Rameshkumar N, Kasireddy A, Maldonado G, Beltran L, Chaugule A, Khan H, Patil N, Patil R, Cartin-Ceba R, Sen A, Talaei F, Kashyap R, Pablo Domecq J, Gajic O, Bansal V, Tekin A, Lal A, O'Horo J, Deo N, Sharma M, Qamar S, Singh R, Valencia Morales D, La Nou A, Bogojevic M, Zec S, Sanghavi D, Guru P, Morno Franco P, Ganaphadithan K, Saunders H, Fleissner Z, Garcia J, Yu Lee Mateus A, Yarrarapu S, Kaur N, Giri A, Mustafa Hasan M, Donepudi A, Khan S, Jain N, Koritala T, Nanchal R, Bergl P, Peterson J, Yamanaka T, Barreras N, Markos M, Fareeduddin A, Mehta R, Venkata C, Engemann M, Mantese A, Tarabichi Y, Perzynski A, Wang C, Kotekal D, Briceno Bierwirth A, Orellana G, Catalasan G, Ahmed S, Matute C, Hamdan A, Salinas I, Nogal G, Tejada A, Chen J, Hope A, Tsagaris Z, Ruen E, Hambardzumyan A, Siddiqi N, Jurado L, Tincher L, Brown C, Aulakh B, Tripathi S, Bandy J, Kreps L, Bollinger D, Scott Stienecker R, Melendez A, Brunner T, Budzon S, Heffernan J, Souder J, Miller T, Maisonneuve A, Redfern R, Shoemaker J, Micham J, Kenney L, Naimy G, J Pulver K, Yehle J, Weeks A, Inman T, Delmonaco B, Franklin A, Heath M, Vilella A, Kutner S, Clark K, Moore D, Anderson H, Rajkumar D, Abunayla A, Heiter J, Zaren H, Smith S, Lewis G, Seames L, Farlow C, Miller J, Broadstreet G, Martinez A, Allison M, Mittal A, Ruiz R, Skaanland A, Ross R, Patel U, Hodge J, Patel K, Dalal S, Kavani H, Joseph S, Bernstein M, Goff I, Naftilan M, Mathew A, Williams D, Murdock S, Ducey M, Nelson K, Block J, Mitchel J, O'Brien C, Cox S, Amzuta I, Shah A, Modi R, Al-Khalisy H, Masuta P, Schafer M, Wratney A, Carter K, Olmos M, Parker B, Quintanilla J, Craig T, Clough B, Jameson J, Gupta N, Jones T, Ayers S, Harrell A, Brown B, Darby C, Page K, Brown A, McAbee J, Belden K, Baram M, Weber D, DePaola R, Xia Y, Carter H, Tolley A, Ferranti M, Steele M, Kemble L, Sethi J, Cheng Han C, Pagliaro J, Husian A, Malhotra A, Zawaydeh Q, Sines B, Bice T, Markotic D, Bosnjak I, Vail E, Nicholson S, Jonas R, Dement A, Tang W, DeRose M, Villarreal R, Dy R, Lardino A, Sharma J, Czieki R, Christopher J, Lacey R, Mashina M, Patel K, Gomaa D, Goodman M, Wakefield D, Spuzzillo A, Shinn II J, Bihorac A, Ozrazgat Baslanti T, Omalay G, Hashemighouchani H, Cupka J, Ruppert M, McGonagill P, Galet C, Hubbard J, Wang D, Allan L, Badheka A, Chegondi M, Nazir U, Rampon G, Riggle J, Dismag N, Akca O, Lenhardt R, Cavallazzi R, Jerde A, Black A, Polidori A, Griffey H, Winkler J, Brenzel T, Alvarez R, Alarocon-Calderon A, Sosa M, Mahabir S, Patel M, Parker P, Admon A, Hanna S, Chanderraj R, Pliakas M, Wolski A, Cirino J, Dandachi D, Regunath H, Camazine M, Geiger G, Njai A, Saad B, Shah F, Chuan B, Rawal S, Piracha M, Tonna J, Levin N, Suslavich K, Tsolinas R, Fica Z, Skidmore C, Stapleton R, Dixon A, Johnson O, Ardren S, Burns S, Raymond A, Gonyaw E, Hodgdon K, Houseger C, Lin B, McQuesten K, Pecott- Grimm H, Sweet J, Ventrone S, Khandelwal N, West T, Caldwell E, Lovelace-Macon L, Garimella N, Dow D, Akhter M, Rahman R, Mulrow M, Wilfong E, Vela K, Khanna A, Harris L, Cusson B, Fowler J, Vaneenenaam D, Mckinney G, Udoh I, Johnson K, Lyons P, Michelson A, Haulf S, Lynch L, Nguyen N, Steinbery A, Braus N, Pattan V, Papke J, Jimada I, Mhid N, Chakola S, Sheth K, Ammar A, Ammar M, Lopez V, Dela Cruz C, Khosla A, Gautam S. Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Network Open 2021, 4: e2140568. PMID: 34935924, PMCID: PMC8696573, DOI: 10.1001/jamanetworkopen.2021.40568.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeRisk of ARDSLength of stayInvasive mechanical ventilationMetabolic syndrome criteriaMetabolic syndromeRespiratory distress syndromeSyndrome criteriaDistress syndromeMechanical ventilationCOVID-19ICU LOSIntensive care unit admissionHospital LOSSARS-CoV-2 infectionCare unit admissionMulticenter cohort studySevere COVID-19Hospital mortalityUnit admissionICU admissionAdult patientsCohort studyCommon comorbiditiesControl patientsAssessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy
Ganesh A, Ospel J, Menon B, Demchuk A, McTaggart R, Nogueira R, Poppe A, Almekhlafi M, Hanel R, Thomalla G, Holmin S, Puetz V, van Adel B, Tarpley J, Tymianski M, Hill M, Goyal M, Barber P, Smith E, Bal S, Subramanian S, Peters S, Couillard P, Klein G, Stys P, Coutts S, Wong J, Mitha A, Eesa M, Morrish W, Alqatani S, Kashani N, Venkatesan P, Teleg E, Sitaram A, Graham B, Gaal S, Moussaddy A, Chakraborty D, Maraj N, Lockey A, Chen S, Singh R, Alsultan A, Asunsian R, Tse D, Doshi D, Volny O, Ojha P, Wadhwa A, Marko M, Singh N, Wasyliw S, Ryckborst K, Kenney C, Save S, Jambula A, Newcommon N, Hull G, Blackstock D, Kiszczak S, Zimmel L, Wright M, Jahraus C, Andersen L, Bohn S, Paul J, Buck B, Butcher K, Shuaib A, Jeerakathil T, Jickling G, Emery D, Rempel J, Ower R, Ashforth R, Yeo T, Kotylak T, O;Kelly C, Chow M, Siddiqui M, Saqqur M, D'Souza A, Lloret M, Butt A, Nomani A, Kalashyan H, Thirunavukkarasu S, Jabs J, Fairall P, Piquette L, Phillips S, Green A, Gubitz G, Heidenreich J, Huynh T, Shankar J, Maloney W, Vandorpe R, Schmidt M, Pickett G, Weeks A, Jarrett J, MacDonald D, Arsenault J, Kinnear R, Mandzia J, Mayich M, Boulton M, Bullrich M, Fridman S, Kiwan R, Lee D, Lownie S, Khaw A, Pandey S, Sharma M, Sposato L, Wade K, Beauchamp B, Lambourn L, Amato-Marziali B, Roy D, Deneault N, Deschaintre Y, Gioia L, Jacquin G, Odier C, Stapf C, Iancu D, Raymond J, Weill A, Lapierre M, Jadil N, Jolteus J, Teitelbaum J, Angle M, Hannouche M, Badawy M, Letourneau J, Cortes M, Linnell G, Tampieri D, Vieira L, Legault C, Durcan L, Moore A, Cole E, Magnussen C, Salmon K, Khalil S, Desloges I, Waxman L, Abdon W, Lai S, Dowlatshahi D, Shamy M, Stotts G, Blacquiere D, Lesiuk H, Quateen A, Drake B, Dewar B, Daham Z, Kelly M, Hunter G, Peeling L, Graham B, Whelan R, Garner A, Urroz L, Maley S, Silver F, Casaubon L, Pikula A, Campo M, Schaafsma J, Jaigobin C, Krings T, Pereira V, Agid R, Farb R, Kalman L, Cayley A, Williams J, Stewart T, Misquitta K, Bharatha A, Selchen D, Marotta T, Sarma D, Montanera W, Spears J, Saposnik G, Kostyrko P, Li Y, Parra-Farinas C, Diestro J, Camden M, Verreault S, Mackey A, Audet M, Milot G, Lavoie P, Gariépy J, Collard K, Haché A, Sahlas D, Alshanbari A, Baldwin J, Catanese L, Chen B, Sa Boasquevisque D, Deshmukh A, Knapman J, Lamers S, Larrazabal R, MacMillan S, Mai L, Mattai A, Nayar S, Ng K, Oczkowski W, Perera K, Shawawrah M, Shoamanesh A, Sobhi G, Syed N, Yaher N, Vandervelde C, Wang D, Field T, Van Gaal S, Teal P, Benavente O, Wilson L, Mann S, Yip S, Murphy C, Heran M, Rohr A, Settecase F, Redekop G, Haw C, Maclean G, Murray K, Chiu R, Flexman A, Strecha E, Gayton Y, Yip J, Swartz R, Boulos M, Gladstone D, Yu A, Hopyan J, Khosravani H, Manosalva Alzate H, Southwell A, Kamra M, Lopes K, Kapoor A, da Costa L, Yang V, Dyer E, Shah R, Knowles B, Nichols J, Patterson J, Cope K, Dickerson L, Barton K, Gray K, Massengale T, Miller M, Simpson C, Walker S, Tennyson-Yemm C, Frei D, Bellon R, Atchie B, Kaminsky I, Wilson D, Schraeder N, Arias E, Kodis L, Talley M, Edinger A, Talley T, Dempsey I, Williams L, Williams S, Kupniewski S, Fasbinder B, Snead J, Choe H, Mackenzie L, Weisman D, Kozak O, Shah Q, Gzesh D, Kulandaivel K, Khoury J, Klein B, Bussinger P, Griffin L, DePalmo A, Oliva C, Jadhav A, Jovin T, Kenmuir C, Jankowitz B, Gross B, Rocha M, Starr M, Brown M, Hawkes C, Shah K, Tememe D, Walker G, Patel P, Klein B, Ziayee H, Limaye K, Baxendell L, Glichrist V, Feineigle P, Toseki Haibach K, Van Every C, Desai S, Zulfiqar M, Gibson L, Barrett S, Turkel-Parrella D, Arcot K, DiCrescento S, Farkas J, Filipowski G, Frontera J, Joset D, Liff J, Scher E, McDougall C, Kelly C, Patel A, Monteith S, Starkman S, Atchaneeyasakul K, Burgos A, Anne Y. Chua J, Gaines N, Grunberg I, Guzy J, Liu Z, Maluste N, Ramirez L, Sharma L, Heck D, Brown M, McDonald C, Calderon M, Hargis M, Roels C, Emmady P, Alvi T, Jayaraman M, Cutting S, Smith W, Foley S, Paolucci G, Haas R, Quinn K, Fuller L, Brierley R, Watkins C, Demir N, Lopez G, Vargas A, Osteraas N, Holtz B, Sauvageau E, Aghaebrahim A, Chmayssani M, Naval N, Day J, Dellorso S, Ludwig B, Schemmel D, Ebreo N, Bell K, Lewis L, Delucia M, Haussen D, Frankel M, Bhatt N, Bianchi N, Anderson A, Belagaje S, Liberato B, Rangaraju S, Al-Bayati A, Grossber J, Craft L, Schindler K, Schaad E, Schultz M, Sutherly L, Doppelheuer S, Charlton J, Faggard J, Barbret Z, DukSoo Han E, Walters R, Dolia J, El-Jamal S, Eby B, Saleem Y, Pearl H, Patel K, Rahman H, Butt R, English S, Puri A, Howk M, Singh J, Massari F, DeMacedo Rodrigues K, Kuhn A, English J, Barazangi N, Telischak N, Kim W, Ross J, DeVole N, Redford J, Ferreira M, Ponting K, Shen H, Bedenk A, Patel S, Fernandess J, Ke M, Spokoyny I, Gao B, Tong D, Chen C, Wong C, Choe J, Martin C, Summers D, Boutwell C, Olds K, Crandall S, Eatman J, Akhtar N, Holloway W, Halpin J, Donegan B, Schindler J, Hwang D, Gilmore E, Petersen N, Sheth K, Brown S, Beekman R, George B, Kaddouh F, Falcone G, Wira C, Matouk C, Loomis C, Amin H, Stretz H, Narula R, Jasne A, Sansing L, Agarwal T, Jasak S, Fontaine B, King Z, Kouhn L, Orgass H, Leary M, Nye J, Halbert K, Nystrom K, Neuschatz K, Petrucci D, Coppola A, Joyce T, Hou S, Umekubo M, Nakamura C, Ovando R, Zuniga D, Nien Y, Basto F, Arch A, Jong L, Conrad W, Abbott T, Yao J, Caganap S, Jordan J, Teitelbaum G, Darflinger R, Kelly D, Gupta R, Budzik R, Czerniak J, Groezinger K, Hicks W, Kaskar O, Katz B, Loochtan A, Pema P, Rai V, Vora N, Brown A, Goodman D, Danenbergs B, Gossett M, Bang O, Chung J, Jeon P, Kim K, Lim Y, Hoe Heo J, Nam H, Kim Y, Park H, Hwang I, Ha W, Choi J, Jeong K, Rha J, Park H, Yoon C, Kim B, Sohn S, Kim C, Yoo J, Hong J, Park H, Kim S, Choi M, Bae H, Lee J, Lee J, Jun G, Jeon S, Campbell B, Mitchell P, Yassi N, Davis S, Donnan G, Parsons M, Yan B, Dowling R, Bush S, Wu T, Shan D, Zhao H, Salvaris P, Alemseged F, Ng F, Williams C, Balabanski A, dos Santos A, Ng J, McDonald A, Jackson D, Tsoleridis J, Pesavento L, Kleinig T, Drew R, Cranefield J, Scroop R, Cagi L, Harvey J, Waters M, Thornton J, Brennan R, O'Hare A, Power S, Williams D, Boyle K, Moynihan B, Liddy A, Large M, Cullen A, Walsh R, Martin E, Lynch J, McElroy S, Murphy S, Coveney S, Deegan C, Horgan G, Kelly P, Laffan A, Llamas-Osorio Y, Lynch C, Mac Mahon P, Marnane M, McCabe J, Burns P, Tauro S, Cuddy S, Rennie I, Smyth G, Flynn P, Wiggam I, Kerr E, Gordon P, Fearon P, Roberts G, Patterson C, Adams K, Wells B, McFarland M, Moreira T, Sjöstrand C, Mazya M, Almqvist H, Wahlgren N, Steinberg A, Cooray C, Eriksson E, Thorén M, Keselman B, Ahmed N, Holmberg Å, Axelsson M, Berglund A, Golsari A, Hoppe J, Deb-Chatterji M, Cheng B, Barow E, Schlemm E, Lettow I, Jensen M, Otto D, Jaramillo K, Appelbohm H, Fiehler J, Bester M, Schönfeld M, Brekenfeld C, Holst B, Wortmann G, Koch F, Gerber J, Abramyuk A, Kaiser D, Winzer S, Prakapenia A, Pallesen L, Siepmann T, Barlinn K, Haase K, Sauer A, Psychogios M, Liman J, Brehm A, Maus V, Hollstein N, Reinke A, Neitz G, Schnieder M, Schwarz M, Ibrahim A, Müller J, Meister S, Bäumle B, Chapot R, Pilgram-Pastor S, Wallocha M, Stauder M, Celik E, Stracke P, Müller N, Weber R, Veltkamp R, Nagel S, Ringleb P, Heyse M, Amiri H, Mundiyanapurath S, Chen M, Beyrle E, Beck P, Möhlenbruch M. Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy. JAMA Network Open 2021, 4: e2132376. PMID: 34739060, PMCID: PMC8571657, DOI: 10.1001/jamanetworkopen.2021.32376.Peer-Reviewed Original ResearchConceptsSerious adverse eventsHigher mRS scoreLower mRS scoresMRS scoreInfarct volumeEndovascular therapyPretreatment factorsPosttreatment factorsBlood pressureHemoglobin levelsFunctional outcomeAnterior Circulation Proximal OcclusionDiscrepant casesHighest FIVTomography/magnetic resonance imagingHigher baseline hemoglobinRecanalization Times (ESCAPE) trialAbsence of diabetesStroke unit careSymptomatic intracerebral hemorrhageCongestive heart failureDiastolic blood pressureRankin Scale scoreMagnetic resonance imagingStepwise model
2019
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Collaborators G, Feigin V, Nichols E, Alam T, Bannick M, Beghi E, Blake N, Culpepper W, Dorsey E, Elbaz A, Ellenbogen R, Fisher J, Fitzmaurice C, Giussani G, Glennie L, James S, Johnson C, Kassebaum N, Logroscino G, Marin B, Mountjoy-Venning W, Nguyen M, Ofori-Asenso R, Patel A, Piccininni M, Roth G, Steiner T, Stovner L, Szoeke C, Theadom A, Vollset S, Wallin M, Wright C, Zunt J, Abbasi N, Abd-Allah F, Abdelalim A, Abdollahpour I, Aboyans V, Abraha H, Acharya D, Adamu A, Adebayo O, Adeoye A, Adsuar J, Afarideh M, Agrawal S, Ahmadi A, Ahmed M, Aichour A, Aichour I, Aichour M, Akinyemi R, Akseer N, Al-Eyadhy A, Salman R, Alahdab F, Alene K, Aljunid S, Altirkawi K, Alvis-Guzman N, Anber N, Antonio C, Arabloo J, Aremu O, Ärnlöv J, Asayesh H, Asghar R, Atalay H, Awasthi A, Quintanilla B, Ayuk T, Badawi A, Banach M, Banoub J, Barboza M, Barker-Collo S, Bärnighausen T, Baune B, Bedi N, Behzadifar M, Behzadifar M, Béjot Y, Bekele B, Belachew A, Bennett D, Bensenor I, Berhane A, Beuran M, Bhattacharyya K, Bhutta Z, Biadgo B, Bijani A, Bililign N, Bin Sayeed M, Blazes C, Brayne C, Butt Z, Campos-Nonato I, Cantu-Brito C, Car M, Cárdenas R, Carrero J, Carvalho F, Castañeda-Orjuela C, Castro F, Catalá-López F, Cerin E, Chaiah Y, Chang J, Chatziralli I, Chiang P, Christensen H, Christopher D, Cooper C, Cortesi P, Costa V, Criqui M, Crowe C, Damasceno A, Daryani A, De la Cruz-Góngora V, De la Hoz F, De Leo D, Demoz G, Deribe K, Dharmaratne S, Diaz D, Dinberu M, Djalalinia S, Doku D, Dubey M, Dubljanin E, Duken E, Edvardsson D, El-Khatib Z, Endres M, Endries A, Eskandarieh S, Esteghamati A, Esteghamati S, Farhadi F, Faro A, Farzadfar F, Farzaei M, Fatima B, Fereshtehnejad S, Fernandes E, Feyissa G, Filip I, Fischer F, Fukumoto T, Ganji M, Gankpe F, Garcia-Gordillo M, Gebre A, Gebremichael T, Gelaw B, Geleijnse J, Geremew D, Gezae K, Ghasemi-Kasman M, Gidey M, Gill P, Gill T, Girma E, Gnedovskaya E, Goulart A, Grada A, Grosso G, Guo Y, Gupta R, Gupta R, Haagsma J, Hagos T, Haj-Mirzaian A, Haj-Mirzaian A, Hamadeh R, Hamidi S, Hankey G, Hao Y, Haro J, Hassankhani H, Hassen H, Havmoeller R, Hay S, Hegazy M, Heidari B, Henok A, Heydarpour F, Hoang C, Hole M, Rad E, Hosseini S, Hu G, Igumbor E, Ilesanmi O, Irvani S, Islam M, Jakovljevic M, Javanbakht M, Jha R, Jobanputra Y, Jonas J, Jozwiak J, Jürisson M, Kahsay A, Kalani R, Kalkonde Y, Kamil T, Kanchan T, Karami M, Karch A, Karimi N, Kasaeian A, Kassa T, Kassa Z, Kaul A, Kefale A, Keiyoro P, Khader Y, Khafaie M, Khalil I, Khan E, Khang Y, Khazaie H, Kiadaliri A, Kiirithio D, Kim A, Kim D, Kim Y, Kim Y, Kisa A, Kokubo Y, Koyanagi A, Krishnamurthi R, Defo B, Bicer B, Kumar M, Lacey B, Lafranconi A, Lansingh V, Latifi A, Leshargie C, Li S, Liao Y, Linn S, Lo W, Lopez J, Lorkowski S, Lotufo P, Lucas R, Lunevicius R, Mackay M, Mahotra N, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Malta D, Manafi N, Mansournia M, Mantovani L, März W, Mashamba-Thompson T, Massenburg B, Mate K, McAlinden C, McGrath J, Mehta V, Meier T, Meles H, Melese A, Memiah P, Memish Z, Mendoza W, Mengistu D, Mengistu G, Meretoja A, Meretoja T, Mestrovic T, Miazgowski B, Miazgowski T, Miller T, Mini G, Mirrakhimov E, Moazen B, Mohajer B, Mezerji N, Mohammadi M, Mohammadi-Khanaposhtani M, Mohammadibakhsh R, Mohammadnia-Afrouzi M, Mohammed S, Mohebi F, Mokdad A, Monasta L, Mondello S, Moodley Y, Moosazadeh M, Moradi G, Moradi-Lakeh M, Moradinazar M, Moraga P, Velásquez I, Morrison S, Mousavi S, Muhammed O, Muruet W, Musa K, Mustafa G, Naderi M, Nagel G, Naheed A, Naik G, Najafi F, Nangia V, Negoi I, Negoi R, Newton C, Ngunjiri J, Nguyen C, Nguyen L, Ningrum D, Nirayo Y, Nixon M, Norrving B, Noubiap J, Shiadeh M, Nyasulu P, Ogah O, Oh I, Olagunju A, Olagunju T, Olivares P, Onwujekwe O, Oren E, Owolabi M, Mahesh P, Pakpour A, Pan W, Panda-Jonas S, Pandian J, Patel S, Pereira D, Petzold M, Pillay J, Piradov M, Polanczyk G, Polinder S, Postma M, Poulton R, Poustchi H, Prakash S, Prakash V, Qorbani M, Radfar A, Rafay A, Rafiei A, Rahim F, Rahimi-Movaghar V, Rahman M, Rahman M, Rahman M, Rajati F, Ram U, Ranta A, Rawaf D, Rawaf S, Reinig N, Reis C, Renzaho A, Resnikoff S, Rezaeian S, Rezai M, González C, Roberts N, Roever L, Ronfani L, Roro E, Roshandel G, Rostami A, Sabbagh P, Sacco R, Sachdev P, Saddik B, Safari H, Safari-Faramani R, Safi S, Safiri S, Sagar R, Sahathevan R, Sahebkar A, Sahraian M, Salamati P, Zahabi S, Salimi Y, Samy A, Sanabria J, Santos I, Milicevic M, Sarrafzadegan N, Sartorius B, Sarvi S, Sathian B, Satpathy M, Sawant A, Sawhney M, Schneider I, Schöttker B, Schwebel D, Seedat S, Sepanlou S, Shabaninejad H, Shafieesabet A, Shaikh M, Shakir R, Shams-Beyranvand M, Shamsizadeh M, Sharif M, Sharif-Alhoseini, She J, Sheikh A, Sheth K, Shigematsu M, Shiri R, Shirkoohi R, Shiue I, Siabani S, Siddiqi T, Sigfusdottir I, Sigurvinsdottir R, Silberberg D, Silva J, Silveira D, Singh J, Sinha D, Skiadaresi E, Smith M, Sobaih B, Sobhani S, Soofi M, Soyiri I, Sposato L, Stein D, Stein M, Stokes M, Sufiyan M, Sykes B, Sylaja P, Tabarés-Seisdedos R, Ao B, Tehrani-Banihashemi A, Temsah M, Temsah O, Thakur J, Thrift A, Topor-Madry R, Tortajada-Girbés M, Tovani-Palone M, Tran B, Tran K, Truelsen T, Tsadik A, Car L, Ukwaja K, Ullah I, Usman M, Uthman O, Valdez P, Vasankari T, Vasanthan R, Veisani Y, Venketasubramanian N, Violante F, Vlassov V, Vosoughi K, Vu G, Vujcic I, Wagnew F, Waheed Y, Wang Y, Weiderpass E, Weiss J, Whiteford H, Wijeratne T, Winkler A, Wiysonge C, Wolfe C, Xu G, Yadollahpour A, Yamada T, Yano Y, Yaseri M, Yatsuya H, Yimer E, Yip P, Yisma E, Yonemoto N, Yousefifard M, Yu C, Zaidi Z, Bin Zaman S, Zamani M, Zandian H, Zare Z, Zhang Y, Zodpey S, Naghavi M, Murray C, Vos T. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 2019, 18: 459-480. PMID: 30879893, PMCID: PMC6459001, DOI: 10.1016/s1474-4422(18)30499-x.Peer-Reviewed Original ResearchConceptsNeurological disordersNational burdenAbsolute numberGlobal burdenAge-standardised DALY ratesBayesian meta-regression toolRisk Factors Study 2016Disorder categoriesCauses of DALYsDisMod-MR 2.1Death Ensemble modelDisease Study 2016Age-standardised ratesTension-type headacheCause of deathComparative risk assessment approachDALY ratesDALY burdenModifiable riskMultiple sclerosisFemale ratioNeurological burdenRisk factorsIdiopathic epilepsyTreatment strategiesGlobal, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Collaborators G, Johnson C, Nguyen M, Roth G, Nichols E, Alam T, Abate D, Abd-Allah F, Abdelalim A, Abraha H, Abu-Rmeileh N, Adebayo O, Adeoye A, Agarwal G, Agrawal S, Aichour A, Aichour I, Aichour M, Alahdab F, Ali R, Alvis-Guzman N, Anber N, Anjomshoa M, Arabloo J, Arauz A, Ärnlöv J, Arora A, Awasthi A, Banach M, Barboza M, Barker-Collo S, Bärnighausen T, Basu S, Belachew A, Belayneh Y, Bennett D, Bensenor I, Bhattacharyya K, Biadgo B, Bijani A, Bikbov B, Bin Sayeed M, Butt Z, Cahuana-Hurtado L, Carrero J, Carvalho F, Castañeda-Orjuela C, Castro F, Catalá-López F, Chaiah Y, Chiang P, Choi J, Christensen H, Chu D, Cortinovis M, Damasceno A, Dandona L, Dandona R, Daryani A, Davletov K, de Courten B, De la Cruz-Góngora V, Degefa M, Dharmaratne S, Diaz D, Dubey M, Duken E, Edessa D, Endres M, FARAON E, Farzadfar F, Fernandes E, Fischer F, Flor L, Ganji M, Gebre A, Gebremichael T, Geta B, Gezae K, Gill P, Gnedovskaya E, Gómez-Dantés H, Goulart A, Grosso G, Guo Y, Gupta R, Haj-Mirzaian A, Haj-Mirzaian A, Hamidi S, Hankey G, Hassen H, Hay S, Hegazy M, Heidari B, Herial N, Hosseini M, Hostiuc S, Irvani S, Islam M, Jahanmehr N, Javanbakht M, Jha R, Jonas J, Jozwiak J, Jürisson M, Kahsay A, Kalani R, Kalkonde Y, Kamil T, Kanchan T, Karch A, Karimi N, Karimi-Sari H, Kasaeian A, Kassa T, Kazemeini H, Kefale A, Khader Y, Khalil I, Khan E, Khang Y, Khubchandani J, Kim D, Kim Y, Kisa A, Kivimäki M, Koyanagi A, Krishnamurthi R, Kumar G, Lafranconi A, Lewington S, Li S, Lo W, Lopez A, Lorkowski S, Lotufo P, Mackay M, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Manafi N, Mansournia M, Mehndiratta M, Mehta V, Mengistu G, Meretoja A, Meretoja T, Miazgowski B, Miazgowski T, Miller T, Mirrakhimov E, Mohajer B, Mohammad Y, Mohammadoo-khorasani M, Mohammed S, Mohebi F, Mokdad A, Mokhayeri Y, Moradi G, Morawska L, Velásquez I, Mousavi S, Muhammed O, Muruet W, Naderi M, Naghavi M, Naik G, Nascimento B, Negoi R, Nguyen C, Nguyen L, Nirayo Y, Norrving B, Noubiap J, Ofori-Asenso R, Ogbo F, Olagunju A, Olagunju T, Owolabi M, Pandian J, Patel S, Perico N, Piradov M, Polinder S, Postma M, Poustchi H, Prakash V, Qorbani M, Rafiei A, Rahim F, Rahimi K, Rahimi-Movaghar V, Rahman M, Rahman M, Reis C, Remuzzi G, Renzaho A, Ricci S, Roberts N, Robinson S, Roever L, Roshandel G, Sabbagh P, Safari H, Safari S, Safiri S, Sahebkar A, Zahabi S, Samy A, Santalucia P, Santos I, Santos J, Milicevic M, Sartorius B, Sawant A, Schutte A, Sepanlou S, Shafieesabet A, Shaikh M, Shams-Beyranvand M, Sheikh A, Sheth K, Shibuya K, Shigematsu M, Shin M, Shiue I, Siabani S, Sobaih B, Sposato L, Sutradhar I, Sylaja P, Szoeke C, Ao B, Temsah M, Temsah O, Thrift A, Tonelli M, Topor-Madry R, Tran B, Tran K, Truelsen T, Tsadik A, Ullah I, Uthman O, Vaduganathan M, Valdez P, Vasankari T, Vasanthan R, Venketasubramanian N, Vosoughi K, Vu G, Waheed Y, Weiderpass E, Weldegwergs K, Westerman R, Wolfe C, Wondafrash D, Xu G, Yadollahpour A, Yamada T, Yatsuya H, Yimer E, Yonemoto N, Yousefifard M, Yu C, Zaidi Z, Zamani M, Zarghi A, Zhang Y, Zodpey S, Feigin V, Vos T, Murray C. Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology 2019, 18: 439-458. PMID: 30871944, PMCID: PMC6494974, DOI: 10.1016/s1474-4422(19)30034-1.Peer-Reviewed Original ResearchConceptsAge-standardised mortality ratesAge-standardised incidenceSocio-demographic IndexSDI quintileGlobal burdenMortality rateAge-standardised DALY ratesTransient ischemic attackBurden of strokePost-stroke careDisease Study 2016Risk Factor StudyCause-specific mortalityNew stroke casesVerbal autopsy dataYears of lifeEstimates of burdenIschemic attackSDI groupCause of diseaseGBD 2016DALY ratesHaemorrhagic strokeIntracerebral hemorrhageAtrial fibrillation
2016
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Collaborators G, Forouzanfar M, Afshin A, Alexander L, Anderson H, Bhutta Z, Biryukov S, Brauer M, Burnett R, Cercy K, Charlson F, Cohen A, Dandona L, Estep K, Ferrari A, Frostad J, Fullman N, Gething P, Godwin W, Griswold M, Hay S, Kinfu Y, Kyu H, Larson H, Liang X, Lim S, Liu P, Lopez A, Lozano R, Marczak L, Mensah G, Mokdad A, Moradi-Lakeh M, Naghavi M, Neal B, Reitsma M, Roth G, Salomon J, Sur P, Vos T, Wagner J, Wang H, Zhao Y, Zhou M, Aasvang G, Abajobir A, Abate K, Abbafati C, Abbas K, Abd-Allah F, Abdulle A, Abera S, Abraham B, Abu-Raddad L, Abyu G, Adebiyi A, Adedeji I, Ademi Z, Adou A, Adsuar J, Agardh E, Agarwal A, Agrawal A, Kiadaliri A, Ajala O, Akinyemiju T, Al-Aly Z, Alam K, Alam N, Aldhahri S, Aldridge R, Alemu Z, Ali R, Alkerwi A, Alla F, Allebeck P, Alsharif U, Altirkawi K, Martin E, Alvis-Guzman N, Amare A, Amberbir A, Amegah A, Amini H, Ammar W, Amrock S, Andersen H, Anderson B, Antonio C, Anwari P, Ärnlöv J, Artaman A, Asayesh H, Asghar R, Assadi R, Atique S, Avokpaho E, Awasthi A, Quintanilla B, Azzopardi P, Bacha U, Badawi A, Bahit M, Balakrishnan K, Barac A, Barber R, Barker-Collo S, Bärnighausen T, Barquera S, Barregard L, Barrero L, Basu S, Batis C, Bazargan-Hejazi S, Beardsley J, Bedi N, Beghi E, Bell B, Bell M, Bello A, Bennett D, Bensenor I, Berhane A, Bernabé E, Betsu B, Beyene A, Bhala N, Bhansali A, Bhatt S, Biadgilign S, Bikbov B, Bisanzio D, Bjertness E, Blore J, Borschmann R, Boufous S, Bourne R, Brainin M, Brazinova A, Breitborde N, Brenner H, Broday D, Brugha T, Brunekreef B, Butt Z, Cahill L, Calabria B, Campos-Nonato I, Cárdenas R, Carpenter D, Carrero J, Casey D, Castañeda-Orjuela C, Rivas J, Castro R, Catalá-López F, Chang J, Chiang P, Chibalabala M, Chimed-Ochir O, Chisumpa V, Chitheer A, Choi J, Christensen H, Christopher D, Ciobanu L, Coates M, Colquhoun S, Manzano A, Cooper L, Cooperrider K, Cornaby L, Cortinovis M, Crump J, Cuevas-Nasu L, Damasceno A, Dandona R, Darby S, Dargan P, Neves J, Davis A, Davletov K, de Castro E, De la Cruz-Góngora V, De Leo D, Degenhardt L, Del Gobbo L, del Pozo-Cruz B, Dellavalle R, Deribew A, Jarlais D, Dharmaratne S, Dhillon P, Diaz-Torné C, Dicker D, Ding E, Dorsey E, Doyle K, Driscoll T, Duan L, Dubey M, Duncan B, Elyazar I, Endries A, Ermakov S, Erskine H, Eshrati B, Esteghamati A, Fahimi S, Faraon E, Farid T, Farinha C, Faro A, Farvid M, Farzadfar F, Feigin V, Fereshtehnejad S, Fernandes J, Fischer F, Fitchett J, Fleming T, Foigt N, Foreman K, Fowkes F, Franklin R, Fürst T, Futran N, Gakidou E, Garcia-Basteiro A, Gebrehiwot T, Gebremedhin A, Geleijnse J, Gessner B, Giref A, Giroud M, Gishu M, Giussani G, Goenka S, Gomez-Cabrera M, Gomez-Dantes H, Gona P, Goodridge A, Gopalani S, Gotay C, Goto A, Gouda H, Gugnani H, Guillemin F, Guo Y, Gupta R, Gupta R, Gutiérrez R, Haagsma J, Hafezi-Nejad N, Haile D, Hailu G, Halasa Y, Hamadeh R, Hamidi S, Handal A, Hankey G, Hao Y, Harb H, Harikrishnan S, Haro J, Hassanvand M, Hassen T, Havmoeller R, Heredia-Pi I, Hernández-Llanes N, Heydarpour P, Hoek H, Hoffman H, Horino M, Horita N, Hosgood H, Hoy D, Hsairi M, Htet A, Hu G, Huang J, Husseini A, Hutchings S, Huybrechts I, Iburg K, Idrisov B, Ileanu B, Inoue M, Jacobs T, Jacobsen K, Jahanmehr N, Jakovljevic M, Jansen H, Jassal S, Javanbakht M, Jayaraman S, Jayatilleke A, Jee S, Jeemon P, Jha V, Jiang Y, Jibat T, Jin Y, Johnson C, Jonas J, Kabir Z, Kalkonde Y, Kamal R, Kan H, Karch A, Karema C, Karimkhani C, Kasaeian A, Kaul A, Kawakami N, Kazi D, Keiyoro P, Kemmer L, Kemp A, Kengne A, Keren A, Kesavachandran C, Khader Y, Khan A, Khan E, Khan G, Khang Y, Khatibzadeh S, Khera S, Khoja T, Khubchandani J, Kieling C, Kim C, Kim D, Kimokoti R, Kissoon N, Kivipelto M, Knibbs L, Kokubo Y, Kopec J, Koul P, Koyanagi A, Kravchenko M, Kromhout H, Krueger H, Ku T, Defo B, Kuchenbecker R, Bicer B, Kuipers E, Kumar G, Kwan G, Lal D, Lalloo R, Lallukka T, Lan Q, Larsson A, Latif A, Lawrynowicz A, Leasher J, Leigh J, Leung J, Levi M, Li X, Li Y, Liang J, Liu S, Lloyd B, Logroscino G, Lotufo P, Lunevicius R, MacIntyre M, Mahdavi, Majdan M, Majeed A, Malekzadeh R, Malta D, Manamo W, Mapoma C, Marcenes W, Martin R, Martinez-Raga J, Masiye F, Matsushita K, Matzopoulos R, Mayosi B, McGrath J, McKee M, Meaney P, Medina C, Mehari A, Mejia-Rodriguez F, Mekonnen A, Melaku Y, Memish Z, Mendoza W, Mensink G, Meretoja A, Meretoja T, Mesfin Y, Mhimbira F, Millear A, Miller T, Mills E, Mirarefin M, Misganaw A, Mock C, Mohammadi A, Mohammed S, Mola G, Monasta L, Hernandez J, Montico M, Morawska L, Mori R, Mozaffarian D, Mueller U, Mullany E, Mumford J, Murthy G, Nachega J, Naheed A, Nangia V, Nassiri N, Newton J, Ng M, Le Nguyen Q, Nisar M, Pete P, Norheim O, Norman R, Norrving B, Nyakarahuka L, Obermeyer C, Ogbo F, Oh I, Oladimeji O, Olivares P, Olsen H, Olusanya B, Olusanya J, Opio J, Oren E, Orozco R, Ortiz A, Ota E, Mahesh P, Pana A, Park E, Parry C, Parsaeian M, Patel T, Caicedo A, Patil S, Patten S, Patton G, Pearce N, Pereira D, Perico N, Pesudovs K, Petzold M, Phillips M, Piel F, Pillay J, Plass D, Polinder S, Pond C, Pope C, Pope D, Popova S, Poulton R, Pourmalek F, Prasad N, Qorbani M, Rabiee R, Radfar A, Rafay A, Rahimi-Movaghar V, Rahman M, Rahman M, Rahman S, Kumar R, Rajsic S, Raju M, Ram U, Rana S, Ranganathan K, Rao P, García C, Refaat A, Rehm C, Rehm J, Reinig N, Remuzzi G, Resnikoff S, Ribeiro A, Rivera J, Roba H, Rodriguez A, Rodriguez-Ramirez S, Rojas-Rueda D, Roman Y, Ronfani L, Roshandel G, Rothenbacher D, Roy A, Saleh M, Sanabria J, Sanchez-Riera L, Sanchez-Niño M, Sánchez-Pimienta T, Sandar L, Santomauro D, Santos I, Sarmiento-Suarez R, Sartorius B, Satpathy M, Savic M, Sawhney M, Schmidhuber J, Schmidt M, Schneider I, Schöttker B, Schutte A, Schwebel D, Scott J, Seedat S, Sepanlou S, Servan-Mori E, Shaddick G, Shaheen A, Shahraz S, Shaikh M, Levy T, Sharma R, She J, Sheikhbahaei S, Shen J, Sheth K, Shi P, Shibuya K, Shigematsu M, Shin M, Shiri R, Shishani K, Shiue I, Shrime M, Sigfusdottir I, Silva D, Silveira D, Silverberg J, Simard E, Sindi S, Singh A, Singh J, Singh P, Slepak E, Soljak M, Soneji S, Sorensen R, Sposato L, Sreeramareddy C, Stathopoulou V, Steckling N, Steel N, Stein D, Stein M, Stöckl H, Stranges S, Stroumpoulis K, Sunguya B, Swaminathan S, Sykes B, Szoeke C, Tabarés-Seisdedos R, Takahashi K, Talongwa R, Tandon N, Tanne D, Tavakkoli M, Taye B, Taylor H, Tedla B, Tefera W, Tegegne T, Tekle D, Terkawi A, Thakur J, Thomas B, Thomas M, Thomson A, Thorne-Lyman A, Thrift A, Thurston G, Tillmann T, Tobe-Gai R, Tobollik M, Topor-Madry R, Topouzis F, Towbin J, Tran B, Dimbuene Z, Tsilimparis N, Tura A, Tuzcu E, Tyrovolas S, Ukwaja K, Undurraga E, Uneke C, Uthman O, van Donkelaar A, van Os J, Varakin Y, Vasankari T, Veerman J, Venketasubramanian N, Violante F, Vollset S, Wagner G, Waller S, Wang J, Wang L, Wang Y, Weichenthal S, Weiderpass E, Weintraub R, Werdecker A, Westerman R, Whiteford H, Wijeratne T, Wiysonge C, Wolfe C, Won S, Woolf A, Wubshet M, Xavier D, Xu G, Yadav A, Yakob B, Yalew A, Yano Y, Yaseri M, Ye P, Yip P, Yonemoto N, Yoon S, Younis M, Yu C, Zaidi Z, Zaki M, Zhu J, Zipkin B, Zodpey S, Zuhlke L, Murray C. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet 2016, 388: 1659-1724. PMID: 27733284, PMCID: PMC5388856, DOI: 10.1016/s0140-6736(16)31679-8.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaAfrica, NorthernAir Pollution, IndoorAlcohol DrinkingBiomarkersBlood GlucoseBody Mass IndexCholesterolCost of IllnessDisabled PersonsEnvironmental ExposureGlobal HealthHumansHypertensionLife ExpectancyMalnutritionMiddle EastOccupational ExposureQuality-Adjusted Life YearsRisk AssessmentRisk FactorsRisk-TakingSmokingSodium, DietarySubstance-Related DisordersUnsafe SexConceptsHigher body mass indexBody mass indexSocio-demographic IndexAttributable DALYsPlasma glucoseHousehold air pollutionMetabolic riskGlobal burdenClusters of risksDrug useChildhood undernutritionAttributable burdenDALY ratesChildhood underweightRisk factorsStudy 2015National comparative risk assessmentRisk Factors Study 2015Risk-deleted DALY ratesHigher systolic blood pressureWorld Cancer Research FundRisk-outcome pairsSummary exposure valueComparative risk assessment frameworkDisease Study 2015Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015
Collaborators G, Lim S, Allen K, Bhutta Z, Dandona L, Forouzanfar M, Fullman N, Gething P, Goldberg E, Hay S, Holmberg M, Kinfu Y, Kutz M, Larson H, Liang X, Lopez A, Lozano R, McNellan C, Mokdad A, Mooney M, Naghavi M, Olsen H, Pigott D, Salomon J, Vos T, Wang H, Abajobir A, Abate K, Abbafati C, Abbas K, Abd-Allah F, Abdulle A, Abraham B, Abubakar I, Abu-Raddad L, Abu-Rmeileh N, Abyu G, Achoki T, Adebiyi A, Adedeji I, Afanvi K, Afshin A, Agarwal A, Agrawal A, Kiadaliri A, Ahmadieh H, Ahmed K, Akanda A, Akinyemi R, Akinyemiju T, Akseer N, Al-Aly Z, Alam K, Alam U, Alasfoor D, AlBuhairan F, Aldhahri S, Aldridge R, Alemu Z, Ali R, Alkerwi A, Alkhateeb M, Alla F, Allebeck P, Allen C, Al-Raddadi R, Alsharif U, Altirkawi K, Martin E, Alvis-Guzman N, Amare A, Amberbir A, Amegah A, Amini H, Ammar W, Amrock S, Andersen H, Anderson B, Anderson G, Antonio C, Anwari P, Ärnlöv J, Artaman A, Asayesh H, Asghar R, Atique S, Avokpaho E, Awasthi A, Quintanilla B, Azzopardi P, Bacha U, Badawi A, Balakrishnan K, Banerjee A, Barac A, Barber R, Barker-Collo S, Bärnighausen T, Barrero L, Barrientos-Gutierrez T, Basu S, Bayou T, Bazargan-Hejazi S, Beardsley J, Bedi N, Beghi E, Béjot Y, Bell M, Bello A, Bennett D, Bensenor I, Benzian H, Berhane A, Bernabé E, Bernal O, Betsu B, Beyene A, Bhala N, Bhatt S, Biadgilign S, Bienhoff K, Bikbov B, Binagwaho A, Bisanzio D, Bjertness E, Blore J, Bourne R, Brainin M, Brauer M, Brazinova A, Breitborde N, Broday D, Brugha T, Buchbinder R, Butt Z, Cahill L, Campos-Nonato I, Campuzano J, Carabin H, Cárdenas R, Carrero J, Carter A, Casey D, Caso V, Castañeda-Orjuela C, Rivas J, Catalá-López F, Cavalleri F, Cecílio P, Chang H, Chang J, Charlson F, Che X, Chen A, Chiang P, Chibalabala M, Chisumpa V, Choi J, Chowdhury R, Christensen H, Ciobanu L, Cirillo M, Coates M, Coggeshall M, Cohen A, Cooke G, Cooper C, Cooper L, Cowie B, Crump J, Damtew S, Dandona R, Dargan P, Neves J, Davis A, Davletov K, de Castro E, De Leo D, Degenhardt L, Del Gobbo L, Deribe K, Derrett S, Jarlais D, Deshpande A, deVeber G, Dey S, Dharmaratne S, Dhillon P, Ding E, Dorsey E, Doyle K, Driscoll T, Duan L, Dubey M, Duncan B, Ebrahimi H, Endries A, Ermakov S, Erskine H, Eshrati B, Esteghamati A, Fahimi S, Farid T, Farinha C, Faro A, Farvid M, Farzadfar F, Feigin V, Felicio M, Fereshtehnejad S, Fernandes J, Fernandes J, Ferrari A, Fischer F, Fitchett J, Fitzmaurice C, Foigt N, Foreman K, Fowkes F, Franca E, Franklin R, Fraser M, Friedman J, Frostad J, Fürst T, Gabbe B, Garcia-Basteiro A, Gebre T, Gebrehiwot T, Gebremedhin A, Gebru A, Gessner B, Gillum R, Ginawi I, Giref A, Giroud M, Gishu M, Giussani G, Godwin W, Gona P, Goodridge A, Gopalani S, Gotay C, Goto A, Gouda H, Graetz N, Greenwell K, Griswold M, Gugnani H, Guo Y, Gupta R, Gupta R, Gupta V, Gutiérrez R, Gyawali B, Haagsma J, Haakenstad A, Hafezi-Nejad N, Haile D, Hailu G, Halasa Y, Hamadeh R, Hamidi S, Hammami M, Hankey G, Harb H, Haro J, Hassanvand M, Havmoeller R, Heredia-Pi I, Hoek H, Horino M, Horita N, Hosgood H, Hoy D, Htet A, Hu G, Huang H, Iburg K, Idrisov B, Inoue M, Islami F, Jacobs T, Jacobsen K, Jahanmehr N, Jakovljevic M, James P, Jansen H, Javanbakht M, Jayaraman S, Jayatilleke A, Jee S, Jeemon P, Jha V, Jiang Y, Jibat T, Jin Y, Jonas J, Kabir Z, Kalkonde Y, Kamal R, Kan H, Kandel A, Karch A, Karema C, Karimkhani C, Karunapema P, Kasaeian A, Kassebaum N, Kaul A, Kawakami N, Kayibanda J, Keiyoro P, Kemmer L, Kemp A, Kengne A, Keren A, Kesavachandran C, Khader Y, Khan A, Khan E, Khan G, Khang Y, Khoja T, Khosravi A, Khubchandani J, Kieling C, Kim C, Kim D, Kim S, Kim Y, Kimokoti R, Kissoon N, Kivipelto M, Knibbs L, Kokubo Y, Kolte D, Kosen S, Kotsakis G, Koul P, Koyanagi A, Kravchenko M, Krueger H, Defo B, Kuchenbecker R, Kuipers E, Kulikoff X, Kulkarni V, Kumar G, Kwan G, Kyu H, Lal A, Lal D, Lalloo R, Lam H, Lan Q, Langan S, Larsson A, Laryea D, Latif A, Leasher J, Leigh J, Leinsalu M, Leung J, Leung R, Levi M, Li Y, Li Y, Lind M, Linn S, Lipshultz S, Liu P, Liu S, Liu Y, Lloyd B, Lo L, Logroscino G, Lotufo P, Lucas R, Lunevicius R, Razek M, Magis-Rodriguez C, Mahdavi, Majdan M, Majeed A, Malekzadeh R, Malta D, Mapoma C, Margolis D, Martin R, Martinez-Raga J, Masiye F, Mason-Jones A, Massano J, Matzopoulos R, Mayosi B, McGrath J, McKee M, Meaney P, Mehari A, Mekonnen A, Melaku Y, Memiah P, Memish Z, Mendoza W, Mensink G, Meretoja A, Meretoja T, Mesfin Y, Mhimbira F, Micha R, Miller T, Mills E, Mirarefin M, Misganaw A, Mitchell P, Mock C, Mohammadi A, Mohammed S, Monasta L, de la Cruz Monis J, Hernandez J, Montico M, Moradi-Lakeh M, Morawska L, Mori R, Mueller U, Murdoch M, Murimira B, Murray J, Murthy G, Murthy S, Musa K, Nachega J, Nagel G, Naidoo K, Naldi L, Nangia V, Neal B, Nejjari C, Newton C, Newton J, Ngalesoni F, Nguhiu P, Nguyen G, Le Nguyen Q, Nisar M, Pete P, Nolte S, Nomura M, Norheim O, Norrving B, Obermeyer C, Ogbo F, Oh I, Oladimeji O, Olivares P, Olusanya B, Olusanya J, Opio J, Oren E, Ortiz A, Osborne R, Ota E, Owolabi M, Mahesh P, Park E, Park H, Parry C, Parsaeian M, Patel T, Patel V, Caicedo A, Patil S, Patten S, Patton G, Paudel D, Pedro J, Pereira D, Perico N, Pesudovs K, Petzold M, Phillips M, Piel F, Pillay J, Pinho C, Pishgar F, Polinder S, Poulton R, Pourmalek F, Qorbani M, Rabiee R, Radfar A, Rahimi-Movaghar V, Rahman M, Rahman M, Rahman S, Kumar R, Rajsic S, Raju M, Ram U, Rana S, Ranabhat C, Ranganathan K, Rao P, Refaat A, Reitsma M, Remuzzi G, Resnikoff S, Ribeiro A, Blancas M, Roba H, Roberts B, Rodriguez A, Rojas-Rueda D, Ronfani L, Roshandel G, Roth G, Rothenbacher D, Roy A, Roy N, Sackey B, Sagar R, Saleh M, Sanabria J, Santos J, Santomauro D, Santos I, Sarmiento-Suarez R, Sartorius B, Satpathy M, Savic M, Sawhney M, Sawyer S, Schmidhuber J, Schmidt M, Schneider I, Schutte A, Schwebel D, Seedat S, Sepanlou S, Servan-Mori E, Shackelford K, Shaheen A, Shaikh M, Levy T, Sharma R, She J, Sheikhbahaei S, Shen J, Sheth K, Shey M, Shi P, Shibuya K, Shigematsu M, Shin M, Shiri R, Shishani K, Shiue I, Sigfusdottir I, Silpakit N, Silva D, Silverberg J, Simard E, Sindi S, Singh A, Singh G, Singh J, Singh O, Singh P, Skirbekk V, Sligar A, Soneji S, Søreide K, Sorensen R, Soriano J, Soshnikov S, Sposato L, Sreeramareddy C, Stahl H, Stanaway J, Stathopoulou V, Steckling N, Steel N, Stein D, Steiner C, Stöckl H, Stranges S, Strong M, Sun J, Sunguya B, Sur P, Swaminathan S, Sykes B, Szoeke C, Tabarés-Seisdedos R, Tabb K, Talongwa R, Tarawneh M, Tavakkoli M, Taye B, Taylor H, Tedla B, Tefera W, Tegegne T, Tekle D, Shifa G, Terkawi A, Tessema G, Thakur J, Thomson A, Thorne-Lyman A, Thrift A, Thurston G, Tillmann T, Tobe-Gai R, Tonelli M, Topor-Madry R, Topouzis F, Tran B, Truelsen T, Dimbuene Z, Tura A, Tuzcu E, Tyrovolas S, Ukwaja K, Undurraga E, Uneke C, Uthman O, van Donkelaar A, Varakin Y, Vasankari T, Vasconcelos A, Veerman J, Venketasubramanian N, Verma R, Violante F, Vlassov V, Volkow P, Vollset S, Wagner G, Wallin M, Wang L, Wanga V, Watkins D, Weichenthal S, Weiderpass E, Weintraub R, Weiss D, Werdecker A, Westerman R, Whiteford H, Wilkinson J, Wiysonge C, Wolfe C, Wolfe I, Won S, Woolf A, Workie S, Wubshet M, Xu G, Yadav A, Yakob B, Yalew A, Yan L, Yano Y, Yaseri M, Ye P, Yip P, Yonemoto N, Yoon S, Younis M, Yu C, Zaidi Z, Zaki M, Zambrana-Torrelio C, Zapata T, Zegeye E, Zhao Y, Zhou M, Zodpey S, Zonies D, Murray C. Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015. The Lancet 2016, 388: 1813-1850. PMID: 27665228, PMCID: PMC5055583, DOI: 10.1016/s0140-6736(16)31467-2.Peer-Reviewed Original ResearchConceptsHealth-related Sustainable Development GoalsHealth-related indicatorsGlobal burdenStudy 2015Risk Factors Study 2015Disease Study 2015Hepatitis B incidenceSocio-demographic IndexChildhood overweightNeonatal mortalityTuberculosis incidenceMelinda Gates FoundationMinimal improvementModern contraceptionHealth improvementModerate improvementBaseline analysisMortalityIncidenceGates FoundationBurdenBest predictorMinimal changesSpline regressionGeometric mean
2015
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke
Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Barrick TR, Moynihan B, Lewis CM, Boncoraglio GB, Lemmens R, Thijs V, Sudlow C, Wardlaw J, Rothwell PM, Meschia JF, Worrall BB, Levi C, Bevan S, Furie KL, Dichgans M, Rosand J, Markus HS, Rost N, Smoller S, Sorkin J, Wang X, Selim M, Pikula A, Wolf P, Debette S, Seshadri S, de Bakker P, Chasman D, Rexrode K, Chen I, Rotter J, Luke M, Sale M, Lee T, Chang K, Elkind M, Goldstein L, James M, Breteler M, O'Donnell C, Leys D, Carty C, Kidwell C, Olesen J, Sharma P, Rich S, Tatlisumak T, Happola O, Bijlenga P, Soriano C, Giralt E, Roquer J, Jimenez-Conde J, Cotlarcius I, Hardy J, Korostynski M, Boncoraglio G, Ballabio E, Parati E, Mateusz A, Urbanik A, Dziedzic T, Jagiella J, Gasowski J, Wnuk M, Olszanecki R, Pera J, Slowik A, Juchniewicz K, Levi C, Nyquist P, Cendes I, Cabral N, Franca P, Goncalves A, Keller L, Crisby M, Kostulas K, Lemmens R, Ahmadi K, Opherk C, Duering M, Dichgans M, Malik R, Gonik M, Staals J, Melander O, Burri P, Sadr-Nabavi A, Romero J, Biffi A, Anderson C, Falcone G, Brouwers B, Rosand J, Rost N, Du R, Kourkoulis C, Battey T, Lubitz S, Mueller-Myhsok B, Meschia J, Brott T, Pare G, Pichler A, Enzinger C, Schmidt H, Schmidt R, Seiler S, Blanton S, Yamada Y, Bersano A, Rundek T, Sacco R, Yvonne Chan Y, Gschwendtner A, Deng Z, Barr T, Gwinn K, Corriveau R, Singleton A, Waddy S, Launer L, Chen C, Le K, Lee W, Tan E, Olugbodi A, Rothwell P, Schilling S, Mok V, Lebedeva E, Jern C, Jood K, Olsson S, Kim H, Lee C, Kilarski L, Markus H, Peycke J, Bevan S, Sheu W, Chiou H, Chern J, Giraldo E, Taqi M, Jain V, Lam O, Howard G, Woo D, Kittner S, Mitchell B, Cole J, O'Connell J, Milewicz D, Illoh K, Worrall B, Stine C, Karaszewski B, Werring D, Sofat R, Smalley J, Lindgren A, Hansen B, Norrving B, Smith G, Martín J, Thijs V, Klijn K, van't Hof F, Algra A, Macleod M, Perry R, Arnett D, Pezzini A, Padovani A, Cramer S, Fisher M, Saleheen D, Broderick J, Kissela B, Doney A, Sudlow C, Rannikmae K, Silliman S, McDonough C, Walters M, Pedersen A, Nakagawa K, Chang C, Dobbins M, McArdle P, Chang Y, Brown R, Brown D, Holliday E, Kalaria R, Maguire J, Attia J, Farrall M, Giese A, Fornage M, Majersik J, Cushman M, Keene K, Bennett S, Tirschwell D, Psaty B, Reiner A, Longstreth W, Spence D, Montaner J, Fernandez-Cadenas I, Langefeld C, Bushnell C, Heitsch L, Lee J, Sheth K. Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology 2015, 86: 146-153. PMID: 26674333, PMCID: PMC4731688, DOI: 10.1212/wnl.0000000000002263.Peer-Reviewed Original ResearchConceptsGenome-wide significant associationGenetic associationGenome-wide levelGenome-wide significanceMeta-analysis testingIndependent lociSuggestive lociGenetic lociLociDisease mechanismsNovel associationsGenetic susceptibilityPopulationCommon genetic susceptibilityDirection of effectReference dataset