2024
White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults
de Havenon A, Gottesman R, Willamson J, Rost N, Sharma R, Li V, Littig L, Stulberg E, Falcone G, Prabhakaran S, Schneider A, Sheth K, Pajewski N, Brickman A. White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults. Alzheimer's & Dementia 2024, 20: 6810-6819. PMID: 39229896, PMCID: PMC11485393, DOI: 10.1002/alz.14126.Peer-Reviewed Original ResearchRisk of cognitive impairmentYears of follow-upCognitive impairmentExposure categoriesHigh-risk categoryWhite matter hyperintensitySystolic Blood Pressure Intervention TrialRates of cognitive impairmentSPRINT-MIND trialDementia preventionFollow-upLow-risk categoryMIND trialAdditional risk factorsDevelopment of cognitive impairmentIntervention trialsHypertensive adultsHazard ratioRisk factorsHigh riskLow riskVascular healthTertileRiskImpairment
2023
The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort
Singh S, Oreskovic T, Carr S, Papier K, Conroy M, Senff J, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Marini S, Nunley C, Newhouse A, Ouyang A, Brouwers H, Westover B, Rivier C, Falcone G, Howard V, Howard G, Pikula A, Ibrahim S, Sheth K, Yechoor N, Lazar R, Anderson C, Tanzi R, Fricchione G, Littlejohns T, Rosand J. The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort. Frontiers In Neurology 2023, 14: 1291020. PMID: 38107629, PMCID: PMC10725202, DOI: 10.3389/fneur.2023.1291020.Peer-Reviewed Original ResearchRisk of dementiaIncident casesIncident dementiaCare scoresLower riskCox proportional hazards regressionSubsequent incident dementiaProportional hazards regressionUK Biobank cohortHazards regressionBaseline evaluationSignificant associationAge groupsDementiaBiobank cohortStrokeDelphi processLifestyle choicesPatientsUKB participantsRiskBaselineBehavior changeAssociationPredictive validityDiabetes-Related Polygenic Risk Is Associated with Poor Glycemic Control and Higher Risk of Acute Cardiovascular Events in Stroke Survivors (P3-5.015)
Demarais Z, Conlon C, Huo S, Rivier C, Renedo D, Sheth K, Falcone G. Diabetes-Related Polygenic Risk Is Associated with Poor Glycemic Control and Higher Risk of Acute Cardiovascular Events in Stroke Survivors (P3-5.015). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202585.Peer-Reviewed Original Research
2018
Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016
Feigin V, Nguyen G, Cercy K, Johnson C, Alam T, Parmar P, Abajobir A, Abate K, Abd-Allah F, Abejie A, Abyu G, Ademi Z, Agarwal G, Ahmed M, Akinyemi R, Al-Raddadi R, Aminde L, Amlie-Lefond C, Ansari H, Asayesh H, Asgedom S, Atey T, Ayele H, Banach M, Banerjee A, Barac A, Barker-Collo S, Bärnighausen T, Barregard L, Basu S, Bedi N, Behzadifar M, Béjot Y, Bennett D, Bensenor I, Berhe D, Boneya D, Brainin M, Campos-Nonato I, Caso V, Castañeda-Orjuela C, Rivas J, Catalá-López F, Christensen H, Criqui M, Damasceno A, Dandona L, Dandona R, Davletov K, de Courten B, deVeber G, Dokova K, Edessa D, Endres M, Faraon E, Farvid M, Fischer F, Foreman K, Forouzanfar M, Gall S, Gebrehiwot T, Geleijnse J, Gillum R, Giroud M, Goulart A, Gupta R, Gupta R, Hachinski V, Hamadeh R, Hankey G, Hareri H, Havmoeller R, Hay S, Hegazy M, Hibstu D, James S, Jeemon P, John D, Jonas J, Jóźwiak J, Kalani R, Kandel A, Kasaeian A, Kengne A, Khader Y, Khan A, Khang Y, Khubchandani J, Kim D, Kim Y, Kivimaki M, Kokubo Y, Kolte D, Kopec J, Kosen S, Kravchenko M, Krishnamurthi R, Kumar G, Lafranconi A, Lavados P, Legesse Y, Li Y, Liang X, Lo W, Lorkowski S, Lotufo P, Loy C, Mackay M, Abd El Razek H, Mahdavi M, Majeed A, Malekzadeh R, Malta D, Mamun A, Mantovani L, Martins S, Mate K, Mazidi M, Mehata S, Meier T, Melaku Y, Mendoza W, Mensah G, Meretoja A, Mezgebe H, Miazgowski T, Miller T, Ibrahim N, Mohammed S, Mokdad A, Moosazadeh M, Moran A, Musa K, Negoi R, Nguyen M, Nguyen Q, Nguyen T, Tran T, Nguyen T, Anggraini Ningrum D, Norrving B, Noubiap J, O’Donnell M, Olagunju A, Onuma O, Owolabi M, Parsaeian M, Patton G, Piradov M, Pletcher M, Pourmalek F, Prakash V, Qorbani M, Rahman M, Rahman M, Rai R, Ranta A, Rawaf D, Rawaf S, Renzaho A, Robinson S, Sahathevan R, Sahebkar A, Salomon J, Santalucia P, Santos I, Sartorius B, Schutte A, Sepanlou S, Shafieesabet A, Shaikh M, Shamsizadeh M, Sheth K, Sisay M, Shin M, Shiue I, Silva D, Sobngwi E, Soljak M, Sorensen R, Sposato L, Stranges S, Suliankatchi R, Tabarés-Seisdedos R, Tanne D, Nguyen C, Thakur J, Thrift A, Tirschwell D, Topor-Madry R, Tran B, Nguyen L, Truelsen T, Tsilimparis N, Tyrovolas S, Ukwaja K, Uthman O, Varakin Y, Vasankari T, Venketasubramanian N, Vlassov V, Wang W, Werdecker A, Wolfe C, Xu G, Yano Y, Yonemoto N, Yu C, Zaidi Z, El Sayed Zaki M, Zhou M, Ziaeian B, Zipkin B, Vos T, Naghavi M, Murray C, Roth G. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. New England Journal Of Medicine 2018, 379: 2429-2437. PMID: 30575491, PMCID: PMC6247346, DOI: 10.1056/nejmoa1804492.Peer-Reviewed Original Research