1998
Suppression of matrix metalloproteinase-2-mediated cell invasion in U87MG, human glioma cells by anti-microtubule agent: in vitro study
Yoshida D, Piepmeier J, Bergenheim T, Henriksson R, Teramoto A. Suppression of matrix metalloproteinase-2-mediated cell invasion in U87MG, human glioma cells by anti-microtubule agent: in vitro study. British Journal Of Cancer 1998, 77: 21-25. PMID: 9459141, PMCID: PMC2151249, DOI: 10.1038/bjc.1998.4.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, AlkylatingCollagenEstramustineGelatinasesGlioblastomaHumansMatrix Metalloproteinase 2MetalloendopeptidasesMicrotubulesNeoplasm InvasivenessNeoplasm ProteinsConceptsMatrix metalloproteinase-2Dose-dependent mannerEstramustine groupMetalloproteinase-2Glioma cellsCell invasionMalignant glioma cellsHuman glioma cellsAnti-microtubule agentsControl groupEstramustineMatrix metalloproteinasesInfiltrative capacityCell invasivenessAntimicrotubule agentsCell proliferationSignificant suppressionDisassembly of microtubulesSignificant differencesU87MG cellsLower ratesInvasionHaptoinvasionCellsGroup
1996
Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy
Piepmeier J, Pedersen P, Yoshida D, Greer C. Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy. Annals Of Surgical Oncology 1996, 3: 543-549. PMID: 8915486, DOI: 10.1007/bf02306087.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, AlkylatingBrain NeoplasmsCarrier ProteinsCell LineColony-Forming Units AssayEstramustineFlow CytometryGlioblastomaHumansImmunohistochemistryMiceMice, NudeMicrotubule-Associated ProteinsNeoplasm TransplantationRadiation-Sensitizing AgentsThymidineTransplantation, HeterologousTumor Cells, CulturedConceptsSubcutaneous xenograftsGlioblastoma cellsHuman glioblastoma cellsMicrotubule-associated proteinsHuman glioblastomaPotent antimitotic effectsUse of estramustineAntimicrotubule agentsEstramustine-binding proteinPreclinical dataEstramustineNeoplastic cellsAntiproliferative effectsSelective therapyGlioma cellsAntimitotic effectCytotoxic effectsGlioblastomaUseful targetTherapyXenograftsLaboratory investigationsSelective effectAntimitotic activityCellsIn vitro inhibition of cell proliferation, viability, and invasiveness in U87MG human glioblastoma cells by estramustine phosphate.
Yoshida D, Piepmeier J, Teramoto A. In vitro inhibition of cell proliferation, viability, and invasiveness in U87MG human glioblastoma cells by estramustine phosphate. Neurosurgery 1996, 39: 360-6. PMID: 8832674, DOI: 10.1097/00006123-199608000-00025.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, AlkylatingBrain NeoplasmsCell DivisionCell LineCell MovementCell SurvivalDose-Response Relationship, DrugEstramustineGlioblastomaHumansNeoplasm InvasivenessTumor Cells, CulturedConceptsEstramustine phosphateMumol/LGlioblastoma cell linesCell proliferationRelative survival ratesTreatment of glioblastomaCell linesTime-dependent depressionAnti-invasive abilityDevelopment of agentsHuman glioblastoma cell linesU87MG human glioblastoma cellsHuman glioblastoma cellsSurvival rateTumor proliferationDrug concentrationsMonotetrazolium assayAntiproliferative capacityCell invasivenessGlioblastoma cellsNon-DNA targetsBasement membraneInvasion indexInvasive potentialSelective antiproliferative activity