The effect of calmodulin inhibitors with bleomycin on the treatment of patients with high grade gliomas.
Hait W, Byrne T, Piepmeier J, Durivage H, Choudhury S, Davis C, Gates J. The effect of calmodulin inhibitors with bleomycin on the treatment of patients with high grade gliomas. Cancer Research 1990, 50: 6636-40. PMID: 1698540.Peer-Reviewed Original ResearchConceptsCentral nervous systemClinical trialsNormal brainNervous systemPhase II clinical trialPhase I clinical trialFatal pulmonary toxicityObjective tumor responseTreatment of patientsHigh-grade gliomasComplete responseCombination therapyPulmonary toxicityTumor responseFatal malignancyMalignant gliomasPreclinical modelsPharmacological characteristicsGrade gliomasGlioblastoma multiformePatientsGliomasRat cerebrumCalmodulin inhibitorsBleomycin