Featured Publications
Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Kumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.Peer-Reviewed Original ResearchConceptsDectin-1 stimulationDendritic cellsHIV-positive older adultsOlder adultsDectin-1 functionDistinct immune signaturesDistinct inflammatory signatureMonocytes of HIVCohort of HIVIFN-α productionPro-inflammatory environmentIFN-γ responsesPro-inflammatory phenotypeInnate immune receptorsDistinct gene signaturesStimulation of monocytesInflammatory signatureImmune signaturesHIV infectionIL-12Macrophage signatureCytokine productionIL-6Cytokine increaseHIV
2022
492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection
Zapata H, Kumar A, Wang J, Shaw A, Zhou H, Radcliffe C, Barakat L, Vander Wyk B, Allore H, Zhao H, Tsang S, Manager D, Mohanty S. 492. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection. Open Forum Infectious Diseases 2022, 9: ofac492.550. PMCID: PMC9751937, DOI: 10.1093/ofid/ofac492.550.Peer-Reviewed Original ResearchDistinct inflammatory signatureIntracellular cytokine stainingPro-inflammatory phenotypeDendritic cellsHIV infectionInflammatory signatureInnate immune pattern recognition receptorsHIV-positive older adultsImmune pattern recognition receptorsOlder adultsDectin-1 functionDendritic cell signatureMonocytes of HIVCohort of HIVPro-inflammatory environmentInnate immune cellsIFN-γ responsesDectin-1 stimulationSetting of agingMTORC-1Whole glucan particleDistinct gene signaturesPattern recognition receptorsDectin-1 agonistCytokine staining