2013
The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration.
Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE. The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration. Current Pharmaceutical Design 2013, 19: 3384-90. PMID: 23432673, DOI: 10.2174/1381612811319190005.Peer-Reviewed Original ResearchConceptsRecombinant human platelet-derived growth factor-BBClinical studiesMesenchymal stem cellsRecombinant human PDGFStrong mitogenic factorHuman platelet-derived growth factor-BBPlatelet-derived growth factor-BBPivotal clinical studiesImproved safety profileTissue repairGrowth factor-BBMechanism of actionDiabetic patientsChronic footSafety profileAnkle fusionPeriodontal diseaseChronic infectionClinical developmentSoft tissue repairAlveolar boneBone autograftHuman PDGFMitogenic factorFactor-BB
1991
The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats
Huo M, Troiano N, Pelker R, Gundberg C, Friedlaender G. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. Journal Of Orthopaedic Research® 1991, 9: 383-390. PMID: 2010842, DOI: 10.1002/jor.1100090310.Peer-Reviewed Original ResearchConceptsControl animalsHistomorphometric parametersFracture repairUnilateral femur fracturesMature Sprague-Dawley ratsSerum osteocalcin levelsCyclo-oxygenase inhibitorSprague-Dawley ratsBone formation rateInfluence of ibuprofenOral doseFemur fracturesOsteocalcin levelsClinical practiceBone volumeBone remodelingInhibitory effectSignificant alterationsFracture biomechanicsRatsAnimalsTail vertebraePresent studyIbuprofenRepair
1987
Bone grafts. The basic science rationale for clinical applications.
Friedlaender G. Bone grafts. The basic science rationale for clinical applications. Journal Of Bone And Joint Surgery 1987, 69: 786-90. PMID: 3298264, DOI: 10.2106/00004623-198769050-00026.Peer-Reviewed Original Research
1978
Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II
Sepe W, Bowers G, Lawrence J, Friedlaender G, Koch R. Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II. Journal Of Periodontology 1978, 49: 9-14. PMID: 340637, DOI: 10.1902/jop.1978.49.1.9.Peer-Reviewed Original Research