2021
Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study
Guerrera F, Falcoz PE, Moser B, van Raemdonck D, Bille’ A, Toker A, Spaggiari L, Ampollini L, Filippini C, Thomas PA, Verdonck B, Mendogni P, Aigner C, Voltolini L, Novoa N, Patella M, Mantovani S, Bravio IG, Zisis C, Guirao A, Londero F, Congregado M, Rocco G, Du Pont B, Martucci N, Esch M, Brunelli A, Detterbeck FC, Venuta F, Weder W, Ruffini E, Centers T, Klepetko W, Olland A, Du Pont B, Nonaka D, Ozkan B, Iacono G, Braggio C, Filosso P, Brioude G, van Schil P, Nosotti M, Valdivia D, Bongiolatti S, Inci I, Dimitra R, Sànchez D, Grossi W, Moreno-Merino S, Teschner M. Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study. European Journal Of Cardio-Thoracic Surgery 2021, 60: 881-887. PMID: 34023891, PMCID: PMC10060729, DOI: 10.1093/ejcts/ezab224.Peer-Reviewed Original ResearchMeSH KeywordsHumansMyasthenia GravisNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesSurgeonsThymectomyThymomaThymus GlandThymus NeoplasmsConceptsEarly-stage thymomaMyasthenia gravisTT groupST groupPropensity score-adjusted comparisonsNon-MG patientsPathological stage IPostoperative morbidity rateEuropean SocietyRate of complicationsCompleteness of resectionOverall survival rateLong-term outcomesProcedure of choiceMost relevant articlesOncological standpointCurative intentPostoperative complicationsPostoperative lengthTotal thymectomyOverall recurrenceThymic tumorsMorbidity rateSurgical approachThymus gland
2019
A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases
Zhao J, Bhatnagar V, Ding L, Atay SM, David EA, McFadden PM, Stamnes S, Lechtholz-Zey E, Wightman SC, Detterbeck FC, Kim AW. A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 306-314.e14. PMID: 31982129, DOI: 10.1016/j.jtcvs.2019.11.052.Peer-Reviewed Original ResearchA Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study
Liu H, Gu Z, Qiu B, Detterbeck FC, Roden AC, Ruffini E, Okumura M, Girard N, Xiang Y, Liu Y, Du Z, Hao Y, Fu J, Zhang P, Pang L, Chen K, Wang Y, Yu Z, Mao T, Fang W, Group A. A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study. Journal Of Thoracic Oncology 2019, 15: 448-456. PMID: 31726106, DOI: 10.1016/j.jtho.2019.10.018.Peer-Reviewed Original ResearchMeSH KeywordsAsian PeopleHumansLung NeoplasmsNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesThymomaThymus NeoplasmsConceptsHigh-risk patientsAdjuvant therapyPostoperative yearThymic carcinomaComplete resectionPostoperative managementNeuroendocrine tumorsBootstrap-corrected C-indexChinese AlliancePostoperative adjuvant therapyIndependent predictive factorsLow-risk patientsMultivariate Cox regressionOverall survival rateAppropriate postoperative managementThymic epithelial tumorsHigh-risk groupLow-risk groupIIIA tumorsLocoregional recurrenceDisease recurrenceB3 thymomaHistologic typeNomogram modelT stage
2015
Multimodality therapy for locally advanced thymomas: A propensity score–matched cohort study from the European Society of Thoracic Surgeons Database
Leuzzi G, Rocco G, Ruffini E, Sperduti I, Detterbeck F, Weder W, Venuta F, Van Raemdonck D, Thomas P, Facciolo F, Group E. Multimodality therapy for locally advanced thymomas: A propensity score–matched cohort study from the European Society of Thoracic Surgeons Database. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 47-57.e1. PMID: 26403869, DOI: 10.1016/j.jtcvs.2015.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAsiaChemotherapy, AdjuvantChildChi-Square DistributionDatabases, FactualDisease ProgressionDisease-Free SurvivalEuropeFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingNorth AmericaPropensity ScoreProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentRisk FactorsSocieties, MedicalThymectomyThymomaThymus NeoplasmsTime FactorsTreatment OutcomeTumor BurdenYoung AdultConceptsRelapse-free survivalAdvanced thymomaMultimodality therapyOverall survivalT classificationPropensity score-matched cohort studyMultivariate Cox proportional hazards modelPropensity score-matched analysisCox proportional hazards modelPathologic T classificationStage III thymomaThoracic Surgeons databaseSignificant survival advantageSpecific pathologic featuresStrong predictive factorProportional hazards modelInduction therapyAdjuvant therapyPT3 tumorsCohort studyIndependent predictorsPrognostic impactMultivariable analysisPathologic featuresPredictive factors
2014
Thymic carcinoma outcomes and prognosis: Results of an international analysis
Ahmad U, Yao X, Detterbeck F, Huang J, Antonicelli A, Filosso PL, Ruffini E, Travis W, Jones DR, Zhan Y, Lucchi M, Rimner A. Thymic carcinoma outcomes and prognosis: Results of an international analysis. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 95-101.e2. PMID: 25524678, DOI: 10.1016/j.jtcvs.2014.09.124.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingPractice Patterns, Physicians'Proportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk FactorsSex FactorsThymectomyThymomaThyroid NeoplasmsTime FactorsTreatment OutcomeConceptsRecurrence-free survivalEarly Masaoka stageR0 resectionOverall survivalRadiation therapyMasaoka stageThymic carcinomaMale genderLonger recurrence-free survivalMedian overall survivalStage IV diseaseAdjuvant radiation therapyMasaoka stage IPreoperative radiation therapyPrimary outcome measureSquamous cell carcinomaPredominant histologic subtypeAdjuvant chemotherapyImproved OSInduction chemotherapyProlonged OSCumulative incidenceHistologic subtypeMultivariable analysisTreatment patternsOutcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
Filosso PL, Yao X, Ahmad U, Zhan Y, Huang J, Ruffini E, Travis W, Lucchi M, Rimner A, Antonicelli A, Guerrera F, Detterbeck F, Committee E. Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 103-109.e2. PMID: 25308116, DOI: 10.1016/j.jtcvs.2014.08.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChemotherapy, AdjuvantDatabases, FactualFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingNeuroendocrine TumorsProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk FactorsThymectomyThymus NeoplasmsTime FactorsTreatment OutcomeYoung AdultConceptsInternational Thymic Malignancy Interest GroupMasaoka-Koga stageOverall survivalCompleteness of resectionPrimary neuroendocrine tumorThoracic Surgeons databasePrognostic factorsHistologic subtypeSurgeons databaseNeuroendocrine tumorsHigher biologic aggressivenessMasaoka-Koga stage ICommon histologic subtypeMedian overall survivalEuropean SocietyRetrospective multicenter studyKaplan-Meier methodStrong prognostic factorLog-rank testInduction therapyAdjuvant treatmentCumulative incidenceResection statusComplete resectionMulticenter studyTumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database
Ruffini E, Detterbeck F, Van Raemdonck D, Rocco G, Thomas P, Weder W, Brunelli A, Evangelista A, Venuta F, Khaled A, Arame A, Refai M, Casadio C, Carbognani P, Cerfolio R, Donati G, Foroulis C, Gebitekin C, de Antonio D, Kernstine K, Keshavjee S, Moser B, Lequaglie C, Liberman M, Lim E, Nicholson A, Lang-Lazdunski L, Mancuso M, Altorki N, Nosotti M, Novoa N, Brioude G, Oliaro A, Filosso P, Saita S, Scarci M, Schützner J, Terzi A, Toker A, Van Veer H, Anile M, Rendina E, Voltolini L, Zurek W. Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database. European Journal Of Cardio-Thoracic Surgery 2014, 46: 361-368. PMID: 24482389, PMCID: PMC4155438, DOI: 10.1093/ejcts/ezt649.Peer-Reviewed Original ResearchConceptsOverall survivalAdjuvant therapyIncomplete resectionComplete resectionThymic tumorsTumor sizeWorld Health Organization histologyTen-year OSDisease-free survivalEuropean SocietyType of resectionClinical pathological characteristicsRisk of recurrenceShorter overall survivalThoracic Surgeons databaseR0 resectionCohort studyCumulative incidenceSecondary outcomesImproved survivalPrimary outcomePrognostic factorsIncident casesPrognostic predictorSurgeons database
2013
Lobectomy Versus Limited Resection in T1N0 Lung Cancer
Detterbeck FC. Lobectomy Versus Limited Resection in T1N0 Lung Cancer. The Annals Of Thoracic Surgery 2013, 96: 742-744. PMID: 23910135, DOI: 10.1016/j.athoracsur.2013.03.074.Peer-Reviewed Original ResearchCarcinoma, Non-Small-Cell LungHumansLung NeoplasmsNeoplasm Recurrence, LocalNeoplasm StagingSurvival RateThymoma: current diagnosis and treatment.
Detterbeck FC, Zeeshan A. Thymoma: current diagnosis and treatment. Chinese Medical Journal 2013, 126: 2186-91. PMID: 23769581, DOI: 10.3760/cma.j.issn.0366-6999.20130177.Peer-Reviewed Original ResearchMeSH KeywordsHumansIncidenceNeoplasm Recurrence, LocalNeoplasm StagingThymomaThymus NeoplasmsTomography, X-Ray ComputedConceptsComplete resectionInternational Thymic Malignancy Interest GroupMasaoka-Koga classificationMainstay of treatmentMajor prognostic factorAnterior mediastinal tumorTreatment of thymomaEarly-stage thymomaRare malignant tumorCore needle biopsyStandard diagnostic modalityFine-needle aspirationFormal systematic reviewMajor blood vesselsIVA tumorsPreoperative chemotherapyPrimary surgeryPostoperative radiationPrognostic factorsSurgical resectionThymic malignanciesMediastinal tumorMyasthenia gravisThymoma resectionIntravenous contrast
2012
Stereotactic Body Radiotherapy for Central Lung Tumors
Rowe BP, Boffa DJ, Wilson LD, Kim AW, Detterbeck FC, Decker RH. Stereotactic Body Radiotherapy for Central Lung Tumors. Journal Of Thoracic Oncology 2012, 7: 1394-1399. PMID: 22843088, DOI: 10.1097/jto.0b013e3182614bf3.Peer-Reviewed Original ResearchConceptsStereotactic body radiotherapyCentral lung tumorsBiological equivalent doseLocal recurrenceTracheobronchial treeLung tumorsBody radiotherapyCentral lesionsEquivalent doseGrade 3Baseline pulmonary function testsLarger maximum tumor diameterMedian biological equivalent doseChest wall painGrade 3 dyspneaYale Cancer CenterGrade 2 toxicityLocal control ratePrimary lung cancerPulmonary function testsHigh-grade toxicityMajority of patientsVolume of lungMaximum tumor diameterMaximum point dose
2011
Pushing Forward Into the Darkness, Leaping, and Landing Securely Prognostication and Adjuvant Chemotherapy for Lung Cancer
Detterbeck FC. Pushing Forward Into the Darkness, Leaping, and Landing Securely Prognostication and Adjuvant Chemotherapy for Lung Cancer. CHEST Journal 2011, 140: 1398-1400. PMID: 22147814, DOI: 10.1378/chest.11-1988.Peer-Reviewed Original ResearchManagement of Thymic Tumors: A Survey of Current Practice among Members of the European Society of Thoracic Surgeons
Ruffini E, Van Raemdonck D, Detterbeck F, Rocco G, Thomas P, Venuta F, Group T. Management of Thymic Tumors: A Survey of Current Practice among Members of the European Society of Thoracic Surgeons. Journal Of Thoracic Oncology 2011, 6: 614-623. PMID: 21266921, DOI: 10.1097/jto.0b013e318207cd74.Peer-Reviewed Original ResearchConceptsThymic tumorsPreoperative assessmentTomography scanThoracic surgeonsPositron emission tomography scanWorld Health Organization classificationRole of surgeryStage IVA thymomaEuropean SocietyEmission tomography scanManagement of thymomasESTS membersReliable staging systemType C thymomasAreas of controversyIVA thymomaExtrapleural pneumonectomyExtended resectionRecurrent diseasePostoperative treatmentThymic malignanciesHistologic confirmationStaging systemOrganization classificationObservational studyManagement of Stage I and II Thymoma
Detterbeck FC, Parsons AM. Management of Stage I and II Thymoma. Thoracic Surgery Clinics 2011, 21: 59-67. PMID: 21070987, DOI: 10.1016/j.thorsurg.2010.08.001.Peer-Reviewed Original ResearchMeSH KeywordsHumansNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapy, AdjuvantThymomaThymus Neoplasms
2010
Standard Outcome Measures for Thymic Malignancies
Huang J, Detterbeck FC, Wang Z, Loehrer PJ. Standard Outcome Measures for Thymic Malignancies. Journal Of Thoracic Oncology 2010, 5: 2017-2023. PMID: 20978450, DOI: 10.1097/jto.0b013e3181f13682.Peer-Reviewed Original ResearchSynchronous, Separate, and Similar
Detterbeck FC. Synchronous, Separate, and Similar. Journal Of Thoracic Oncology 2010, 5: 150-152. PMID: 20101142, DOI: 10.1097/jto.0b013e3181c81500.Peer-Reviewed Original Research
2004
Thymic tumors
Detterbeck FC, Parsons AM. Thymic tumors. The Annals Of Thoracic Surgery 2004, 77: 1860-1869. PMID: 15111216, DOI: 10.1016/j.athoracsur.2003.10.001.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoid TumorCombined Modality TherapyHumansNeoplasm Recurrence, LocalPrognosisRadiotherapy, AdjuvantThymomaThymus NeoplasmsConceptsComplete resectionThymic tumorsMainstay of treatmentSurvival of patientsIVA thymomaPostoperative radiotherapyThymic carcinomaPreoperative chemotherapyIndolent coursePartial resectionStage IIIResectionThymomaPatientsAggressive behaviorTumorsLittle benefitSuch casesChemotherapyCarcinomaRadiotherapyMainstay
2003
The ABCs of LTX for BAC
Egan TM, Detterbeck FC. The ABCs of LTX for BAC. Journal Of Thoracic And Cardiovascular Surgery 2003, 125: 20-22. PMID: 12538975, DOI: 10.1067/mtc.2003.146.Peer-Reviewed Original ResearchAdenocarcinoma, Bronchiolo-AlveolarHumansLungLung NeoplasmsLung TransplantationNeoplasm Recurrence, Local