2017
Effectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians
Arnold BN, Thomas DC, Rosen JE, Salazar MC, Detterbeck FC, Blasberg JD, Boffa DJ, Kim AW. Effectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians. Surgery 2017, 162: 640-651. PMID: 28697883, DOI: 10.1016/j.surg.2017.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overCarcinoma, Non-Small-Cell LungConfidence IntervalsDatabases, FactualDisease-Free SurvivalFemaleGeriatric AssessmentHumansKaplan-Meier EstimateLogistic ModelsLung NeoplasmsMaleMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingOdds RatioPneumonectomyProportional Hazards ModelsRadiotherapyRegistriesRisk AssessmentSecondary PreventionSurvival AnalysisConceptsCell lung cancerLocal therapyLung cancerStage IRelative survivalStereotactic body radiation therapyNational Cancer DatabaseBetter overall survivalBody radiation therapyOlder patientsOverall survivalPatient ageYounger patientsOverall mortalityPrimary outcomeCancer DatabaseTreatment outcomesTreatment decisionsRadiation therapyPatientsTherapyCancerNonagenariansTreatmentSurvival
2016
Hospital Volume and Outcomes of Robot-Assisted Lobectomies
Tchouta LN, Park HS, Boffa DJ, Blasberg JD, Detterbeck FC, Kim AW. Hospital Volume and Outcomes of Robot-Assisted Lobectomies. CHEST Journal 2016, 151: 329-339. PMID: 27687847, DOI: 10.1016/j.chest.2016.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedCase-Control StudiesCohort StudiesDatabases, FactualFemaleHospital MortalityHospitals, High-VolumeHospitals, Low-VolumeHumansLength of StayLinear ModelsLogistic ModelsLungLung NeoplasmsMaleMiddle AgedMultivariate AnalysisPneumonectomyPostoperative ComplicationsRetrospective StudiesRobotic Surgical ProceduresThoracic Surgery, Video-AssistedTreatment OutcomeConceptsLength of stayLow-volume centersHospital volumeClinical impactHealth care system-related factorsShorter mean LOSUtilization Project National Inpatient Sample databaseVolume/outcome relationshipLong-term clinical impactMean LOSNational Inpatient Sample databaseShorter LOSVideo-assisted thoracoscopic surgeryHospital operative volumeHigh-volume hospitalsIncidence of complicationsHigher hospital volumeThoracoscopic surgery lobectomyAnnual case volumeSystem-related factorsOutcomes of interestLOS outcomesInfectious complicationsInpatient mortalityIndependent predictorsEstimating the Annual Incremental Cost of Several Complications Following Pulmonary Lobectomy
Jawitz OK, Boffa DJ, Detterbeck FC, Wang Z, Kim AW. Estimating the Annual Incremental Cost of Several Complications Following Pulmonary Lobectomy. Seminars In Thoracic And Cardiovascular Surgery 2016, 28: 531-540. PMID: 28043473, DOI: 10.1053/j.semtcvs.2016.06.001.Peer-Reviewed Original ResearchConceptsAcute respiratory failureLength of hospitalizationPulmonary lobectomyHospital stayRespiratory failureMajor complicationsAir leakAnnual health care expendituresRetrospective cohort analysisNational Inpatient SampleLength of stayPostoperative air leaksUtilization Project databaseAnnual incremental costMultivariable quantile regression modelsAggregate national costHealth care expendituresHealth care qualityLarge national datasetCommon complicationVATS lobectomyCostly complicationInpatient SampleHospital costsClinical data
2015
Multimodality therapy for locally advanced thymomas: A propensity score–matched cohort study from the European Society of Thoracic Surgeons Database
Leuzzi G, Rocco G, Ruffini E, Sperduti I, Detterbeck F, Weder W, Venuta F, Van Raemdonck D, Thomas P, Facciolo F, Group E. Multimodality therapy for locally advanced thymomas: A propensity score–matched cohort study from the European Society of Thoracic Surgeons Database. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 47-57.e1. PMID: 26403869, DOI: 10.1016/j.jtcvs.2015.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAsiaChemotherapy, AdjuvantChildChi-Square DistributionDatabases, FactualDisease ProgressionDisease-Free SurvivalEuropeFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingNorth AmericaPropensity ScoreProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentRisk FactorsSocieties, MedicalThymectomyThymomaThymus NeoplasmsTime FactorsTreatment OutcomeTumor BurdenYoung AdultConceptsRelapse-free survivalAdvanced thymomaMultimodality therapyOverall survivalT classificationPropensity score-matched cohort studyMultivariate Cox proportional hazards modelPropensity score-matched analysisCox proportional hazards modelPathologic T classificationStage III thymomaThoracic Surgeons databaseSignificant survival advantageSpecific pathologic featuresStrong predictive factorProportional hazards modelInduction therapyAdjuvant therapyPT3 tumorsCohort studyIndependent predictorsPrognostic impactMultivariable analysisPathologic featuresPredictive factors
2014
Thymic carcinoma outcomes and prognosis: Results of an international analysis
Ahmad U, Yao X, Detterbeck F, Huang J, Antonicelli A, Filosso PL, Ruffini E, Travis W, Jones DR, Zhan Y, Lucchi M, Rimner A. Thymic carcinoma outcomes and prognosis: Results of an international analysis. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 95-101.e2. PMID: 25524678, DOI: 10.1016/j.jtcvs.2014.09.124.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingPractice Patterns, Physicians'Proportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk FactorsSex FactorsThymectomyThymomaThyroid NeoplasmsTime FactorsTreatment OutcomeConceptsRecurrence-free survivalEarly Masaoka stageR0 resectionOverall survivalRadiation therapyMasaoka stageThymic carcinomaMale genderLonger recurrence-free survivalMedian overall survivalStage IV diseaseAdjuvant radiation therapyMasaoka stage IPreoperative radiation therapyPrimary outcome measureSquamous cell carcinomaPredominant histologic subtypeAdjuvant chemotherapyImproved OSInduction chemotherapyProlonged OSCumulative incidenceHistologic subtypeMultivariable analysisTreatment patternsOutcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
Filosso PL, Yao X, Ahmad U, Zhan Y, Huang J, Ruffini E, Travis W, Lucchi M, Rimner A, Antonicelli A, Guerrera F, Detterbeck F, Committee E. Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 103-109.e2. PMID: 25308116, DOI: 10.1016/j.jtcvs.2014.08.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChemotherapy, AdjuvantDatabases, FactualFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingNeuroendocrine TumorsProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk FactorsThymectomyThymus NeoplasmsTime FactorsTreatment OutcomeYoung AdultConceptsInternational Thymic Malignancy Interest GroupMasaoka-Koga stageOverall survivalCompleteness of resectionPrimary neuroendocrine tumorThoracic Surgeons databasePrognostic factorsHistologic subtypeSurgeons databaseNeuroendocrine tumorsHigher biologic aggressivenessMasaoka-Koga stage ICommon histologic subtypeMedian overall survivalEuropean SocietyRetrospective multicenter studyKaplan-Meier methodStrong prognostic factorLog-rank testInduction therapyAdjuvant treatmentCumulative incidenceResection statusComplete resectionMulticenter studyFewer complications result from a video-assisted approach to anatomic resection of clinical stage I lung cancer
Boffa DJ, Dhamija A, Kosinski AS, Kim AW, Detterbeck FC, Mitchell JD, Onaitis MW, Paul S. Fewer complications result from a video-assisted approach to anatomic resection of clinical stage I lung cancer. Journal Of Thoracic And Cardiovascular Surgery 2014, 148: 637-643. PMID: 24529729, DOI: 10.1016/j.jtcvs.2013.12.045.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overFemaleHumansLogistic ModelsLung NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm StagingOdds RatioPneumonectomyPostoperative ComplicationsPropensity ScoreRisk FactorsThoracic Surgery, Video-AssistedThoracotomyTime FactorsTreatment OutcomeYoung AdultConceptsStage I lung cancerClinical stage I lung cancerI lung cancerThoracic Surgeons databaseAnatomic resectionLung cancerSurgeons databaseStage I primary lung cancerVideo-assisted thoracic surgery approachEarly-stage lung cancerMore pulmonary complicationsClinical stage ILung cancer resectionPrimary lung cancerMorbidity of patientsThoracic surgery approachStage lung cancerStandard of careMorbidity of thoracotomyVideo-assisted approachLower mortality rateOverall complicationsPulmonary complicationsThoracotomy groupVATS cohort
2013
Impact of preoperative radiation on survival of patients with T3N0 >7-cm non–small cell lung cancers treated with anatomic resection using the Surveillance, Epidemiology, and End Results database
Moreno AC, Morgensztern D, Yu JB, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. Impact of preoperative radiation on survival of patients with T3N0 >7-cm non–small cell lung cancers treated with anatomic resection using the Surveillance, Epidemiology, and End Results database. Journal Of Surgical Research 2013, 184: 10-18. PMID: 23583079, DOI: 10.1016/j.jss.2013.03.053.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellFemaleFollow-Up StudiesHumansIncidenceKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyPneumonectomyPreoperative CareProportional Hazards ModelsSEER ProgramYoung AdultConceptsNon-small cell lung cancerLung cancer-specific survivalEnd Results (SEER) databaseNeoadjuvant radiationSurvival of patientsCell lung cancerResults databaseLung cancerLarge non-small cell lung cancersFive-year overallCancer-specific survivalEffect of surgeryKaplan-Meier methodCox regression modelLog-rank testCombination of chemotherapyLong-term survivalAnatomic resectionPreoperative radiationWorse OSTherapeutic challengeLarge tumorsPneumonectomyLobectomyPatients
2012
Characteristics Associated With the Use of Nonanatomic Resections Among Medicare Patients Undergoing Resections of Early-Stage Lung Cancer
Kim AW, Detterbeck FC, Boffa DJ, Decker RH, Soulos PR, Cramer LD, Gross CP. Characteristics Associated With the Use of Nonanatomic Resections Among Medicare Patients Undergoing Resections of Early-Stage Lung Cancer. The Annals Of Thoracic Surgery 2012, 94: 895-901. PMID: 22835558, PMCID: PMC3501201, DOI: 10.1016/j.athoracsur.2012.04.091.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overCarcinoma, Non-Small-Cell LungConfidence IntervalsDisease-Free SurvivalEthnicityFemaleHumansLogistic ModelsLungLung NeoplasmsMaleMedicareMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingOdds RatioPneumonectomyPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentSEER ProgramSex DistributionSurvival AnalysisUnited StatesConceptsChronic obstructive pulmonary diseaseNonanatomic resectionStage I NSCLCSurgical resectionSurgical approachLung cancerNational Cancer Institute's SurveillanceEarly-stage lung cancerPatients 67 yearsPrimary tumor statusObstructive pulmonary diseaseCell lung cancerHospital factorsLung resectionWedge resectionClinical factorsPulmonary diseaseMultivariable analysisTumor sizeLarge tumorsHospital characteristicsTumor statusMedicare patientsResectionPatientsThoroughness of Mediastinal Staging in Stage IIIA Non-small Cell Lung Cancer
Vest MT, Tanoue L, Soulos PR, Kim AW, Detterbeck F, Morgensztern D, Gross CP. Thoroughness of Mediastinal Staging in Stage IIIA Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2012, 7: 188-195. PMID: 22134069, PMCID: PMC3253367, DOI: 10.1097/jto.0b013e318236ecbb.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleCarcinoma, Non-Small-Cell LungCohort StudiesComorbidityConfidence IntervalsGuideline AdherenceHumansLung NeoplasmsLymph NodesMediastinoscopyMediastinumMedicareMultivariate AnalysisNeoplasm StagingOdds RatioPositron-Emission TomographySEER ProgramSurvival AnalysisUnited StatesConceptsStage IIIA non-small cell lung cancerIIIA non-small cell lung cancerNon-small cell lung cancerInvasive stagingCell lung cancerMediastinal stagingLung cancerClinical stage IIIA non-small cell lung cancerEnd Results-Medicare databaseStage IIIA NSCLC patientsPositron emission tomography scanningPathologic lymph nodesIIIA NSCLC patientsMultivariable logistic regressionInvasive mediastinal stagingNSCLC patientsOlder patientsPatient characteristicsLymph nodesPatient factorsHistologic confirmationPractice patternsMedicare claimsMedicare beneficiariesPET scanning
2010
Standard Outcome Measures for Thymic Malignancies
Huang J, Detterbeck FC, Wang Z, Loehrer PJ. Standard Outcome Measures for Thymic Malignancies. Journal Of Thoracic Oncology 2010, 5: 2017-2023. PMID: 20978450, DOI: 10.1097/jto.0b013e3181f13682.Peer-Reviewed Original Research
2009
High Expression of Mammalian Target of Rapamycin Is Associated with Better Outcome for Patients with Early Stage Lung Adenocarcinoma
Anagnostou VK, Bepler G, Syrigos KN, Tanoue L, Gettinger S, Homer RJ, Boffa D, Detterbeck F, Rimm DL. High Expression of Mammalian Target of Rapamycin Is Associated with Better Outcome for Patients with Early Stage Lung Adenocarcinoma. Clinical Cancer Research 2009, 15: 4157-4164. PMID: 19509151, DOI: 10.1158/1078-0432.ccr-09-0099.Peer-Reviewed Original ResearchConceptsLung cancer patientsMTOR expressionCancer patientsMammalian targetEarly-stage lung adenocarcinomaHigh mTOR expressionIndependent lower riskMedian overall survivalStage IA patientsProtein expressionSubgroup of patientsLung adenocarcinoma patientsStage lung adenocarcinomaMTOR protein expressionRole of mTOROverall survivalPathologic characteristicsPatient survivalValidation cohortAdenocarcinoma groupAdenocarcinoma patientsPrognostic stratificationLung cancerTraining cohortFavorable outcome
2006
Clinical Value of the WHO Classification System of Thymoma
Detterbeck FC. Clinical Value of the WHO Classification System of Thymoma. The Annals Of Thoracic Surgery 2006, 81: 2328-2334. PMID: 16731193, DOI: 10.1016/j.athoracsur.2005.11.067.Peer-Reviewed Original ResearchConceptsWHO systemWorld Health Organization histologic classification systemWHO classification systemIndependent prognostic valueDistinct patient groupsHistologic classification systemClinical management decisionsWHO typePrognostic valuePatient groupClinical valueMultivariate analysisClassification systemThymoma