2019
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
Ligibel JA, Dillon D, Giobbie-Hurder A, McTiernan A, Frank E, Cornwell M, Pun M, Campbell N, Dowling RJO, Chang MC, Tolaney S, Chagpar AB, Yung RL, Freedman RA, Dominici LS, Golshan M, Rhei E, Taneja K, Huang Y, Brown M, Winer EP, Jeselsohn R, Irwin ML. Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study. Clinical Cancer Research 2019, 25: 5398-5406. PMID: 31018921, DOI: 10.1158/1078-0432.ccr-18-3143.Peer-Reviewed Original ResearchConceptsPre-operative healthBreast cancerExercise interventionKi-67Exercise participantsLower cancer-specific mortalityPre-operative exercise interventionCancer-specific mortalityControl participantsBody mass indexTumor immune infiltratesImpact of exerciseBreast cancer proliferationMinutes/weekBreast cancer diagnosisOpportunity trialBaseline biopsiesImmune infiltratesMass indexSurgical excisionMean ageIntervention periodGene expressionChanges of expressionBreast tumors
2016
Randomized trial of a physical activity intervention in women with metastatic breast cancer
Ligibel JA, Giobbie-Hurder A, Shockro L, Campbell N, Partridge AH, Tolaney SM, Lin NU, Winer EP. Randomized trial of a physical activity intervention in women with metastatic breast cancer. Cancer 2016, 122: 1169-1177. PMID: 26872302, DOI: 10.1002/cncr.29899.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsChemotherapy, AdjuvantChi-Square DistributionCombined Modality TherapyDisease-Free SurvivalExercise TherapyFemaleFollow-Up StudiesHumansMastectomy, SegmentalMiddle AgedNeoplasm InvasivenessNeoplasm StagingPhysical FitnessQuality of LifeRadiotherapy, AdjuvantReference ValuesSurvival AnalysisTreatment OutcomeUnited StatesConceptsMetastatic breast cancerEarly-stage breast cancerExercise interventionBreast cancerPhysical functioningLife Questionnaire-Core 30 questionnaireModerate-intensity aerobic exercisePhysical Activity Recall interviewModerate-intensity exercise interventionAdvanced breast cancerPhysical activity interventionsTime of enrollmentWait-list control groupQuality of lifeMetastatic diseaseCancer QualityMedian ageIntervention armMedian timeActivity interventionsAerobic exerciseWeekly exerciseTreadmill testFunctional capacityNonsignificant increase
2010
Physical and Psychological Outcomes Among Women in a Telephone-Based Exercise Intervention During Adjuvant Therapy for Early Stage Breast Cancer
Ligibel JA, Partridge A, Giobbie-Hurder A, Campbell N, Shockro L, Salinardi T, Winer EP. Physical and Psychological Outcomes Among Women in a Telephone-Based Exercise Intervention During Adjuvant Therapy for Early Stage Breast Cancer. Journal Of Women's Health 2010, 19: 1553-1559. PMID: 20629579, DOI: 10.1089/jwh.2009.1760.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerStage breast cancerExercise interventionBreast cancerWeight gainAdjuvant therapyHome-based exercise interventionModerate-intensity aerobic exercise interventionSingle-arm pilot studyIntensive chemotherapy regimensAerobic exercise interventionBreast cancer patientsActivity/weekBreast cancer recurrenceBreast cancer diagnosisAdjuvant chemotherapyChemotherapy regimensPostoperative complicationsSedentary womenWeek 12Cancer outcomesPoor QoLCancer patientsCardiorespiratory fitnessWeekly exercise
2009
Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors
Ligibel JA, Giobbie-Hurder A, Olenczuk D, Campbell N, Salinardi T, Winer EP, Mantzoros CS. Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors. Cancer Causes & Control 2009, 20: 1523-1528. PMID: 19434504, DOI: 10.1007/s10552-009-9358-3.Peer-Reviewed Original ResearchConceptsHigh molecular weight adiponectinBreast cancer survivorsLevels of adiponectinMolecular weight adiponectinCancer survivorsExercise interventionWeight adiponectinOverweight breast cancer survivorsUsual care control groupEndurance exercise interventionCare control groupBreast cancer riskImpact of exerciseBody fat percentageAdipocytokine levelsExercise groupSignificant changesHip circumferenceMethodsOne hundredSignificant inverse relationshipBreast cancerAdiponectinCancer riskHip measurementsAnthropometric measurementsImpact of a home-based physical activity intervention upon exercise behaviors and anthropometric measures in women undergoing treatment for early stage breast cancer.
Ligibel J, Campbell N, Anita G, Shockro L, Salinardi T, Winer E. Impact of a home-based physical activity intervention upon exercise behaviors and anthropometric measures in women undergoing treatment for early stage breast cancer. Cancer Research 2009, 69: 1117. DOI: 10.1158/0008-5472.sabcs-1117.Peer-Reviewed Original ResearchEarly-stage breast cancerStage breast cancerHome-based exercise interventionBreast cancer patientsQuality of lifeBreast cancerWeight gainAdjuvant chemotherapyExercise interventionCancer patientsPhysical activityBody fatAnthropometric measuresHome-based physical activity interventionSingle-arm pilot studyWeek 12 valuesBreast cancer outcomesPhysical activity interventionsTime of enrollmentArm pilot studyBreast cancer riskImpact of exerciseLean muscle massBreast cancer diagnosisAdjuvant therapy
2008
Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors
Ligibel JA, Campbell N, Partridge A, Chen WY, Salinardi T, Chen H, Adloff K, Keshaviah A, Winer EP. Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors. Journal Of Clinical Oncology 2008, 26: 907-912. PMID: 18281663, DOI: 10.1200/jco.2007.12.7357.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsExercise groupCancer survivorsInsulin levelsExercise interventionInsulin concentrationsGlucose levelsBody compositionControl groupOverweight breast cancer survivorsUsual care control groupEndurance exercise interventionCare control groupMicroU/mLSignificant decreaseBreast cancer recurrenceBreast cancer riskBreast cancer prognosisInsulin resistanceHip circumferenceCancer recurrenceBody fatHip measurementsPhysical activityCancer risk
2007
Impact of physical activity on insulin levels in breast cancer survivors
Ligibel J, Campbell N, Chen H, Salinardi T, Chen W, Partridge A, Mantzoros C, Winer E. Impact of physical activity on insulin levels in breast cancer survivors. Journal Of Clinical Oncology 2007, 25: 555-555. DOI: 10.1200/jco.2007.25.18_suppl.555.Peer-Reviewed Original ResearchBreast cancer survivorsInsulin levelsPhysical activityCancer survivorsExercise groupΜIU/Glucose levelsControl groupEarly-stage breast cancerBreast cancer-related deathsBaseline insulin levelsCare control groupStage breast cancerBreast cancer recurrenceBreast cancer riskCancer-related deathBreast cancer prognosisStrength training sessionMeasurements of weightAdjuvant treatmentExercise interventionHip circumferenceInsulin sensitivityCancer recurrenceFat mass
2006
The impact of an exercise intervention on body composition, fat distribution, and weight in breast cancer survivors
Ligibel J, Chen W, Keshaviah A, Adloff K, Partridge A, Salinardi T, Winer E. The impact of an exercise intervention on body composition, fat distribution, and weight in breast cancer survivors. Journal Of Clinical Oncology 2006, 24: 590-590. DOI: 10.1200/jco.2006.24.18_suppl.590.Peer-Reviewed Original ResearchExercise interventionBreast cancer survivorsStrength training sessionBody compositionExercise groupCancer survivorsFat distributionControl groupEarly-stage breast cancerAnthropometric dataSupervised strength trainingCare control groupStage breast cancerBreast cancer recurrenceLance Armstrong FoundationComplete anthropometric dataMeasurements of weightNon-significant changesTraining sessionsAdjuvant chemotherapyObese womenEntire cohortInsulin levelsBiomarker testingCancer recurrence