2011
Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors
Serebryany E, Zhu GA, Yan EC. Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors. Biochimica Et Biophysica Acta 2011, 1818: 225-233. PMID: 21851807, DOI: 10.1016/j.bbamem.2011.07.047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneHumansLipid BilayersMembrane ProteinsModels, MolecularProtein ConformationReceptors, G-Protein-CoupledConceptsFunctional reconstitutionG proteinsMembrane protein structuresNative-like environmentSeven-transmembrane G-proteinMembrane-like environmentTransmembrane proteinLipidic cubic phaseCell signalingPlanar lipid membranesProtein structureMembrane mimicsMolecular levelGPCR researchLipid vesiclesLipid membranesMembraneReceptorsReconstitutionUse of micellesGPCRsSignalingNanodiscsProteinVesicles
2010
In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Vibrational Sum Frequency Generation
Fu L, Ma G, Yan EC. In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Vibrational Sum Frequency Generation. Journal Of The American Chemical Society 2010, 132: 5405-5412. PMID: 20337445, DOI: 10.1021/ja909546b.Peer-Reviewed Original ResearchMeSH KeywordsAmyloidHumansIslet Amyloid PolypeptideKineticsPhosphatidylglycerolsProtein ConformationProtein FoldingSpectrum AnalysisConceptsChiral optical responseSum-frequency generationCharacteristic optical propertiesSum frequency generation spectroscopyVibrational sum frequency generationAir/water interfaceFrequency generationOptical propertiesFrequency generation spectroscopyPolarization settingsGeneration spectroscopyWater interfaceInterface ProbedChiral structureStretch frequencyParallel beta-sheet structure