2013
Chiral Sum Frequency Generation for In Situ Probing Proton Exchange in Antiparallel β‑Sheets at Interfaces
Fu L, Xiao D, Wang Z, Batista VS, Yan EC. Chiral Sum Frequency Generation for In Situ Probing Proton Exchange in Antiparallel β‑Sheets at Interfaces. Journal Of The American Chemical Society 2013, 135: 3592-3598. PMID: 23394622, PMCID: PMC9208335, DOI: 10.1021/ja3119527.Peer-Reviewed Original ResearchConceptsD exchangeChiral sum frequency generation (SFG) spectroscopySum frequency generation spectroscopyHydrogen/deuterium exchangeSurface-selective methodFrequency generation spectroscopyVibrational modesAir/water interfaceAb initio simulationsWater OD stretch bandsH bondsPeptide backboneGeneration spectroscopyN stretchBulk solutionProton exchangeD stretchWater interfaceAntiparallel β-sheetDeuterium exchangeStretch bandFourier transformMass spectroscopyInitio simulations
2010
In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Vibrational Sum Frequency Generation
Fu L, Ma G, Yan EC. In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Vibrational Sum Frequency Generation. Journal Of The American Chemical Society 2010, 132: 5405-5412. PMID: 20337445, DOI: 10.1021/ja909546b.Peer-Reviewed Original ResearchConceptsChiral optical responseSum-frequency generationCharacteristic optical propertiesSum frequency generation spectroscopyVibrational sum frequency generationAir/water interfaceFrequency generationOptical propertiesFrequency generation spectroscopyPolarization settingsGeneration spectroscopyWater interfaceInterface ProbedChiral structureStretch frequencyParallel beta-sheet structure