2016
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
Spracklen CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A, Keating BJ, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia. Hypertension In Pregnancy 2016, 36: 30-35. PMID: 27657194, PMCID: PMC5538572, DOI: 10.1080/10641955.2016.1223303.Peer-Reviewed Original ResearchConceptsC-reactive proteinGenetic risk scoreRisk of preeclampsiaBody mass indexGenetic predispositionCRP levelsPreeclampsia casesRisk scoreCRP genetic risk scoreElevated C-reactive proteinLeisure-time physical activityBlood CRP levelsIndependent replication populationMarkers of preeclampsiaElevated levelsMedical chart reviewLive birth certificatesLogistic regression analysisInverse linear trendChart reviewIowa womenNormotensive controlsDecreased riskMass indexPhysical activity
2013
Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism
Gamsiz ED, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt M, Consortium S, Triche EW, Geschwind DH, State MW, Istrail S, Cook EH, Devlin B, Morrow EM. Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism. American Journal Of Human Genetics 2013, 93: 103-109. PMID: 23830515, PMCID: PMC3710760, DOI: 10.1016/j.ajhg.2013.06.004.Peer-Reviewed Original ResearchConceptsGenome-wide analysisRare deleterious variantsDistinct genetic architecturesAutism candidate genesExome sequence dataGenetic architectureSingle geneROH burdenCandidate genesDeleterious variantsAutosomal recessive mutationSimplex autismGenesProportion of femalesIntellectual disabilityHomozygosityFamilyLociUnaffected siblingsMutationsAutism spectrum disorderFemalesProbandsVariants
2011
Association of variants in innate immune genes with asthma and eczema
Sharma S, Poon A, Himes BE, Lasky‐Su J, Sordillo JE, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA. Association of variants in innate immune genes with asthma and eczema. Pediatric Allergy And Immunology 2011, 23: 315-323. PMID: 22192168, PMCID: PMC3412627, DOI: 10.1111/j.1399-3038.2011.01243.x.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAsthmaBayes TheoremChild, PreschoolEczemaFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansImmunity, InnateMalePolymorphism, Single NucleotideConceptsInnate immune genesPathogenesis of asthmaInnate immune pathwaysSingle nucleotide polymorphismsAsthma StudyImmune genesImmune pathwaysChildhood Asthma StudyPolymorphisms of genesAssociation of variantsChildhood asthmaEczema riskAsthmaCase controlEczemaImmune variantsAdditional single nucleotide polymorphismsBayesian network analysisHome allergensScreening algorithmDifferent genetic determinantsTop single nucleotide polymorphismsPathogenesisMultiple comparisonsDisease susceptibility