2024
A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCognitive Behavioral TherapyConnecticutFemaleHumansMaleMiddle AgedTreatment OutcomeConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treat
2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamineModulation of “Protective” Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-cigarettes
DeVito EE, Jensen KP, O’Malley S, Gueorguieva R, Krishnan-Sarin S, Valentine G, Jatlow PI, Sofuoglu M. Modulation of “Protective” Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-cigarettes. Nicotine & Tobacco Research 2019, 22: 771-781. PMID: 30995302, PMCID: PMC7368338, DOI: 10.1093/ntr/ntz057.Peer-Reviewed Original ResearchConceptsSubjective drug effectsNicotine-containing e-liquidsSelf-administered more nicotineAversive effectsSingle testing dayE-cigarettesSelf-reported preferencesE-cigarette appealRs16969968 genotypePreliminary findingsUnflavored e-liquidsIndividual differencesDrug effectsAd libitumE-liquidsAversive actionsTobacco productsNicotine effectsLow-risk groupNicotine-free e-liquidsPalatable flavorAversivenessTesting daysNicotinic acetylcholine receptor subunit genesNumber of puffs
2018
E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders
DeVito E, Buta E, Sofuoglu M. E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders. Addictive Behaviors 2018, 92: 53-57. PMID: 30583091, PMCID: PMC6699503, DOI: 10.1016/j.addbeh.2018.12.013.Peer-Reviewed Original ResearchConceptsElectronic cigarettesNicotine levelsTobacco useTake-home trialOne monthNicotine electronic cigarettesHigh nicotine dependenceComorbid psychiatric disordersSmoking-related outcomesCombustible cigarette useNicotine e-liquidCombustible tobacco useBaseline characteristicsCessation aidCigarette smokersSmoking characteristicsNicotine doseWorse outcomesEC efficacyNicotine dependenceSmokersPsychiatric disordersCigarette useCombustible cigarettesSmokingStructural correlates of cognitive impairment in normal pressure hydrocephalus
Peterson KA, Mole TB, Keong NCH, DeVito EE, Savulich G, Pickard JD, Sahakian BJ. Structural correlates of cognitive impairment in normal pressure hydrocephalus. Acta Neurologica Scandinavica 2018, 139: 305-312. PMID: 30428124, PMCID: PMC6492129, DOI: 10.1111/ane.13052.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusNPH patientsNeuropsychiatric symptomsPressure hydrocephalusNeuropsychiatric measuresNeuropsychological testsStructure volumesStriatal volume lossDeep gray matter structuresMeasures of apathySubcortical deep gray matter structuresT1-weighted magnetic resonanceGray matter structuresNAcc volumeSmaller caudateNeuropsychiatric changesHealthy controlsPathological basisNPH groupCaudate nucleusNucleus accumbensCaudate volumePatientsSubcortical regionsCognitive impairment
2017
Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus
Keong NC, Pena A, Price SJ, Czosnyka M, Czosnyka Z, DeVito EE, Housden CR, Sahakian BJ, Pickard JD. Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus. PLOS ONE 2017, 12: e0181624. PMID: 28817574, PMCID: PMC5560677, DOI: 10.1371/journal.pone.0181624.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusWhite matter injuryDiffusion tensor imagingPressure hydrocephalusInternal capsulePosterior limbDTI measuresPatterns of injuryDifferent white matter tractsNon-invasive biomarkersWhite matter tractsInferior longitudinal fasciculusClinical outcomesInjury patternsNPH patientsEarly diagnosisLongitudinal fasciculusAxial diffusivityTensor imagingInjuryHydrocephalusPatientsImaging profileIndividual tractsTractFunctional Neural Changes Following Behavioral Therapies and Disulfiram for Cocaine Dependence
DeVito EE, Dong G, Kober H, Xu J, Carroll KM, Potenza MN. Functional Neural Changes Following Behavioral Therapies and Disulfiram for Cocaine Dependence. Psychology Of Addictive Behaviors 2017, 31: 534-547. PMID: 28714728, PMCID: PMC5548432, DOI: 10.1037/adb0000298.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyContingency managementPrecentral gyrusNeural activityFrontal gyrusWhole-brain correlation analysesRandomized clinical trialsSample overallBeginning of treatmentForm of treatmentMedial frontal gyrusInferior parietal lobuleCocaine use disorderDifferent treatment componentsMedication daysClinical trialsTreatment outcomesUse disordersTreatment relateFunctional changesParietal lobuleGyrusTreatment componentsGreater reductionTreatmentAtomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects
DeVito EE, Herman AI, Konkus NS, Zhang H, Sofuoglu M. Atomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects. Pharmacology Biochemistry And Behavior 2017, 159: 55-61. PMID: 28716656, PMCID: PMC5573182, DOI: 10.1016/j.pbb.2017.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultAffectAtomoxetine HydrochlorideAttentionCocaine-Related DisordersCognitionCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFemaleHemodynamicsHumansInhibition, PsychologicalMaleMemory, Short-TermMiddle AgedNeuropsychological TestsSex CharacteristicsConceptsCocaine use disorderMeasures of attentionAbstinent cocaine usersSubjective drug effectsHuman laboratory studiesResponse inhibitionCognitive enhancementAbstinent individualsCognitive enhancersBehavioral treatmentAddictive processClinical populationsAtomoxetineCognitive impairmentNorepinephrine transporter inhibitorUse disordersCocaine usersCardiovascular effectsMoodMedication effectsPoor clinical outcomeDose-dependent effectIndividualsDrug effectsMemory
2016
Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2015
Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus
Peterson KA, Housden CR, Killikelly C, DeVito EE, Keong NC, Savulich G, Czosnyka Z, Pickard JD, Sahakian BJ. Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus. British Journal Of Neurosurgery 2015, 30: 38-42. PMID: 25968325, DOI: 10.3109/02688697.2015.1029429.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusMini-Mental State ExaminationApathy Evaluation ScaleGeriatric Depression ScaleShunt surgeryApathetic symptomsPressure hydrocephalusBicaudate ratioSubcortical atrophyCaudate atrophyFunctional outcomeGDS scoresNeurocognitive improvementDepression ScaleCognitive recoveryLevel of apathyState ExaminationVentriculomegalySurgerySymptomsCognitive outcomesHydrocephalusAtrophyEvaluation ScaleGoal-directed behaviorA CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans
Jensen KP, DeVito EE, Herman AI, Valentine GW, Gelernter J, Sofuoglu M. A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. Neuropsychopharmacology 2015, 40: 2813-2821. PMID: 25948103, PMCID: PMC4864657, DOI: 10.1038/npp.2015.131.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCognition DisordersCotinineFemaleGenome-Wide Association StudyHeart RateHumansMaleMiddle AgedNerve Tissue ProteinsNeuropsychological TestsNicotineNicotinic AgonistsPolymorphism, Single NucleotideReceptors, NicotinicSmokingSubstance Withdrawal SyndromeSurveys and QuestionnairesConceptsAversive effectsHeavy smokingRisk allelesSmoking-related disordersAfrican American smokersCHRNA5-CHRNA3Doses of nicotineHigh nicotine doseNicotine administrationIntravenous doseNicotine effectsNicotine doseAmerican smokersWithdrawal severityOvernight abstinenceAcute responseAA subjectsCardiovascular reactivityCHRNB4 gene clusterNicotineEuropean AmericansAversive responsesAdministration sessionsSmokingCognitive performanceCatehol‐o‐methyltransferase gene Val158met polymorphism as a potential predictor of response to computer‐assisted delivery of cognitive‐behavioral therapy among cocaine‐dependent individuals: Preliminary findings from a randomized controlled trial
Carroll KM, Herman A, DeVito EE, Frankforter TL, Potenza MN, Sofuoglu M. Catehol‐o‐methyltransferase gene Val158met polymorphism as a potential predictor of response to computer‐assisted delivery of cognitive‐behavioral therapy among cocaine‐dependent individuals: Preliminary findings from a randomized controlled trial. American Journal On Addictions 2015, 24: 443-451. PMID: 25930952, PMCID: PMC4516567, DOI: 10.1111/ajad.12238.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyVal carriersStandard treatmentCocaine-dependent individualsCocaine useStandard methadone maintenance treatmentComputer-assisted deliveryMethadone maintenance treatmentMet/Met genotypeRate of participantsSignificant treatment conditionLess cocaine useCOMT Val108/158Met polymorphismPreliminary data pointUncontrolled studiesMaintenance treatmentContinuous abstinenceTreatment outcomesTreatment responseWeek trialMet genotypePotential biomarkersBehavioral therapyVal108/158Met polymorphism
2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMen
2013
Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase
DeVito EE, Herman AI, Waters AJ, Valentine GW, Sofuoglu M. Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase. Neuropsychopharmacology 2013, 39: 1431-1440. PMID: 24345818, PMCID: PMC3988546, DOI: 10.1038/npp.2013.339.Peer-Reviewed Original ResearchConceptsSubjective drug effectsMenstrual cycle phaseDrug effectsNicotine dependenceMenstrual cycle phase effectsFollicular phase womenSerious public health concernCycle phase effectsSymptoms of withdrawalLuteal phase femalesPublic health concernMenstrual phase differencesNicotine administrationOptimal treatmentIntravenous nicotineLuteal phaseOvernight abstinenceSmoking behaviorCycle phaseNicotine responseGreater physiological responsesBiochemical confirmationHealth concernEffects of sexBetter cognitionA preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes
Mitchell MR, Balodis IM, DeVito EE, Lacadie CM, Yeston J, Scheinost D, Constable RT, Carroll KM, Potenza MN. A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes. The American Journal Of Drug And Alcohol Abuse 2013, 39: 392-402. PMID: 24200209, PMCID: PMC3827911, DOI: 10.3109/00952990.2013.841711.Peer-Reviewed Original ResearchConceptsTreatment outcomesComparison subjectsCocaine-dependent patientsIntrinsic connectivityCocaine dependenceSubstantia nigraVentral striatumTreatment-seeking cocaine-dependent patientsHealthy comparison subjectsPotential treatment targetGreater intrinsic connectivityRegional brain activationCocaine-dependent groupIntrinsic connectivity analysesNon-addicted individualsBasal gangliaInferior frontal gyrusCocaine-dependent individualsTreatment targetsFMRI Stroop taskSubcortical regionsCocaine abstinenceBrain regionsAnterior insulaFrontal gyrusGender differences in a clinical trial for prescription opioid dependence
McHugh RK, DeVito EE, Dodd D, Carroll KM, Potter JS, Greenfield SF, Connery HS, Weiss RD. Gender differences in a clinical trial for prescription opioid dependence. Journal Of Substance Use And Addiction Treatment 2013, 45: 38-43. PMID: 23313145, PMCID: PMC3626739, DOI: 10.1016/j.jsat.2012.12.007.Peer-Reviewed Original ResearchConceptsPrescription opioid dependenceOpioid dependenceClinical trialsOpioid dependence severityPrescription drug dependenceLarge clinical trialsOpioid use outcomesGreater functional impairmentRoute of administrationSubstance use disordersGender differencesGreater psychiatric severityClinical characteristicsMedication doseStudy treatmentOpioid outcomesFunctional impairmentTreatment outcomesPre-treatment differencesPsychiatric severityTreatment retentionUse disordersLegitimate prescriptionDrug dependenceOpioids
2011
Reliance on habits at the expense of goal-directed control following dopamine precursor depletion
de Wit S, Standing HR, DeVito EE, Robinson OJ, Ridderinkhof KR, Robbins TW, Sahakian BJ. Reliance on habits at the expense of goal-directed control following dopamine precursor depletion. Psychopharmacology 2011, 219: 621-631. PMID: 22134475, PMCID: PMC3249188, DOI: 10.1007/s00213-011-2563-2.Peer-Reviewed Original ResearchConceptsDopamine functionOutcome devaluation testRecent animal studiesGoal-directed action controlRole of dopamineStimulus-response habitsPlacebo groupDietary interventionHabitual controlTyrosine depletionHealthy volunteersDietary phenylalanineAnimal studiesFemale volunteersStimulus-response learningAction controlGoal-directed actionsDopamineSubject comparisonsVolunteersOutcomesGender differencesRewarding outcomesInitial learning phaseGoal-directed controlA preliminary study of the neural effects of behavioral therapy for substance use disorders
DeVito EE, Worhunsky PD, Carroll KM, Rounsaville BJ, Kober H, Potenza MN. A preliminary study of the neural effects of behavioral therapy for substance use disorders. Drug And Alcohol Dependence 2011, 122: 228-235. PMID: 22041256, PMCID: PMC3296894, DOI: 10.1016/j.drugalcdep.2011.10.002.Peer-Reviewed Original ResearchConceptsComputer-assisted cognitive behavioral therapyBehavioral therapySubstance use disordersInferior frontal gyrusCognitive behavioral therapyMaintenance of addictionUse disordersSubstance use outcomesCognitive controlFrontal gyrusTest-retest conditionsNeural effectsComponent of treatmentAnterior cingulateImpulse controlNeural systemsSame taskUse outcomesBOLD signalSubstance useSubstance abuseStroopComparison groupRandomized clinical trialsHealthy controls
2010
Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
Robinson OJ, Standing HR, DeVito EE, Cools R, Sahakian BJ. Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males. Psychopharmacology 2010, 211: 187-195. PMID: 20495788, PMCID: PMC2892070, DOI: 10.1007/s00213-010-1880-1.Peer-Reviewed Original ResearchConceptsDA synthesisHealthy individualsParkinson's diseaseMale subjectsPlacebo-controlled crossover designCertain psychiatric disordersPunishment processingDA depletionDopamine synthesisHealthy femalesPsychiatric disordersCrossover designFemale subjectsDiseaseNeurotransmitter dopamineGender biasesReward processingThree-way interactionReversal learningSubjectsDepletion procedurePunishment predictionGender differencesSignificant improvement