2014
Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells
Bleakley M, Heimfeld S, Jones LA, Turtle C, Krause D, Riddell SR, Shlomchik W. Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells. Transplantation And Cellular Therapy 2014, 20: 705-716. PMID: 24525279, PMCID: PMC3985542, DOI: 10.1016/j.bbmt.2014.01.032.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsHematopoietic cell transplantationMemory T cellsStem cell graftsT cellsCell graftsPathogen-specific memory T cellsPeripheral blood stem cell graftsAllogeneic stem cell graftsBlood stem cell graftsNaïve T cell subsetsAllogeneic hematopoietic cell transplantationFrequent major complicationCentral memory phenotypeT cell subsetsBlood stem cellsNaïve T cellsOpportunistic pathogenCommon opportunistic pathogenStem cellsHost diseaseHCT outcomesEffector cytokinesMajor complicationsMemory phenotype
2003
Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice
Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, Krause DS. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Experimental Hematology 2003, 31: 413-420. PMID: 12763140, DOI: 10.1016/s0301-472x(03)00042-0.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsNOD/SCID miceMesenchymal stem cellsMSC cotransplantationTransplant recipientsSCID miceCotransplantation of MSCsHematopoietic stem cellsHuman peripheral blood stem cellsStem cellsAllogeneic transplant recipientsTransplantation of CD34Autologous transplant recipientsHuman mesenchymal stem cellsBlood stem cellsHuman cell engraftmentMarrow-derived stromal cellsBone marrow cellsPlatelet engraftmentHuman bone marrow cellsHuman hematopoietic stem cellsCotransplantationBone marrowMegakaryocytic engraftmentB lymphocytes
2001
Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production
Perez L, Rinder H, Wang C, Tracey J, Maun N, Krause D. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production. Blood 2001, 97: 1635-1643. PMID: 11238102, DOI: 10.1182/blood.v97.6.1635.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsHuman peripheral blood stem cellsPlatelet productionVivo modelStudy of megakaryocytopoiesisCFU-MKHuman megakaryocytopoiesisImmunodeficient miceBone marrowHuman plateletsExogenous cytokinesNOD/SCID miceHuman hematopoiesisBlood stem cellsHuman cell engraftmentPlatelet developmentNonobese diabetic/Lymphoid lineageStem cellsHuman blood CD34MegakaryocytopoiesisPeripheral bloodCytokine stimulationMurine recipientsThrombin stimulation